NPK 1886
- Product Name
- NPK 1886
- CAS No.
- 94739-29-4
- Chemical Name
- NPK 1886
- Synonyms
- NB-818;NPK 1886;Ccris 7339;Bamilodipine;4-(2,3-Dichlorophenyl)-1,4-dihydro-2-[[(carbamoyl)oxy]methyl]-6-methyl-3,5-pyridinedicarboxylic acid 3-isopropyl 5-methyl ester;(-)-2-carbamoyloxymethyl-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-methyl ester;3-Isopropyl 5-methyl (+-)-4-(2,3-dichlorophenyl)-1,4-dihydro-2-(hydroxymethyl)-6-methyl-3,5-pyridinedicarboxylate, carbamate (ester);3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(2,3-dichlorophenyl)-2-(hydroxymethyl)-6-methyl-,3-isopropyl 5-methyl ester, carbamate (ester);3,5-Pyridinedicarboxylic acid, 2-(((aminocarbonyl)oxy)methyl)-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-, 5-methyl 3-(1-methylethyl) ester
- CBNumber
- CB51340357
- Molecular Formula
- C20H22Cl2N2O6
- Formula Weight
- 457.30448
- MOL File
- 94739-29-4.mol
NPK 1886 Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to yellow
N-Bromosuccinimide Price
- Product number
- CS-6628
- Product name
- Lemildipine
- Purity
- 98.06%
- Packaging
- 5mg
- Price
- $380
- Updated
- 2021/12/16
- Product number
- CS-6628
- Product name
- Lemildipine
- Purity
- 98.06%
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- CS-6628
- Product name
- Lemildipine
- Purity
- 98.06%
- Packaging
- 25mg
- Price
- $1150
- Updated
- 2021/12/16
- Product number
- CS-6628
- Product name
- Lemildipine
- Purity
- 98.06%
- Packaging
- 50mg
- Price
- $1800
- Updated
- 2021/12/16
- Product number
- CS-6628
- Product name
- Lemildipine
- Purity
- 98.06%
- Packaging
- 100mg
- Price
- $2850
- Updated
- 2021/12/16
NPK 1886 Chemical Properties,Usage,Production
Uses
Lemildipine is a calcium ion channel blocker that effects the renal blood flow in mammals.
Definition
ChEBI: Lemildipine is a dihydropyridine, an isopropyl ester and a methyl ester.
in vivo
Gerbils are treated intraperitoneally with Lemildipine (0.1-3 mg/kg) just after release of the occlusion. Four days after the ischemia, they are fixed by perfusing 10% buffered-formalin, and the neuronal cell density (NCD, cell/mm) in the CA1 subfield is estimated under microscopy. The average NCD in the ischemic control group is 43±10.8 cells/mm, whereas Lemildipine (3 mg/kg) significantly ameliorates DND with an average NCD of 143±24.2 cells/mm (P<0.01). In addition, Lemildipine (3 mg/kg) significantly inhibits delayed neuronal death (DND) at 1, 2 and 4 weeks after transient ischemia: the average NCD of the Lemildipine and ischemic control groups are 80±9.4 (P<0.01) and 43±7.7 cells/mm, 92±13.7 (P<0.05) and 52±9.3 cells/mm, and 57±5.0 (P<0.01) and 43±12.4 cells/mm, respectively. In this experiment, Lemildipine (NB-818) exhibits a protective effect on DND in the hippocampal CA1 subfield after transient forebrain ischemia, and its effect persisted for up to 4 weeks[1]. In normal Wistar rats (NWR), Lemildipine (NPK-1886) in doses of 3-30 mg/kg, p.o., produces a mild lowering of blood pressure. The depressor effect of Lemildipine is much the same as that of Nifedipine. In contrast, Lemildipine produces a significant decrease in the blood pressure of spontaneously hypertensive rats (SHR). Oral administration of Lemildipine in doses of 3, 10, 30 mg/kg produces a significant decrease in systolic blood pressure dose-dependently. The maximum decrease is observed 1-3 hr after administration. Comparing the hypotensive potency of Lemildipine and Nifedipine, their dose-response curves at the maximum response during the observation (for 24 hr) are analyzed by the least squares method, and the dose of 30% decrease in blood pressure from the control level (ED30) are used as a measure of their potency. Lemildipine is 1.4 times stronger than Nifedipine; the ED30 values of Lemildipine and Nifedipine are 10.2 mg/kg and 14.3 mg/kg, respectively[2].
NPK 1886 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from NPK 1886 manufacturers
- Product
- Lemildipine 94739-29-4
- Price
- US $1.39/KG
- Min. Order
- 200g/Bag
- Purity
- 99%
- Supply Ability
- 30KG
- Release date
- 2021-12-16