pluviatolide
- Product Name
- pluviatolide
- CAS No.
- 28115-68-6
- Chemical Name
- pluviatolide
- Synonyms
- pluviatolide;trans-Pluviatolide;3α-(4-Hydroxy-3-methoxybenzyl)-4β-(1,3-benzodioxole-5-ylmethyl)-4,5-dihydrofuran-2(3H)-one;4,5-Dihydro-4β-[(1,3-benzodioxole-5-yl)methyl]-3α-(4-hydroxy-3-methoxybenzyl)furan-2(3H)-one;2(3H)-Furanone, 4-(1,3-benzodioxol-5-ylmethyl)dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-, (3R,4R)-;(3R,4R)-4-[(1,3-Benzodioxol-5-yl)methyl]-4,5-dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]furan-2(3H)-one
- CBNumber
- CB51346359
- Molecular Formula
- C20H20O6
- Formula Weight
- 356.37
- MOL File
- 28115-68-6.mol
pluviatolide Property
- storage temp.
- Store at -20°C
- solubility
- DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
- form
- A solid
- color
- White to off-white
- LogP
- 2.590 (est)
N-Bromosuccinimide Price
- Product number
- 29582
- Product name
- Pluviatolide
- Packaging
- 1mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 29582
- Product name
- Pluviatolide
- Packaging
- 5mg
- Price
- $571
- Updated
- 2024/03/01
- Product number
- 1467CB
- Product name
- Pluviatolide
- Packaging
- 1mg
- Price
- $268
- Updated
- 2021/12/16
- Product number
- CFN92059
- Product name
- Pluviatolide
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $464
- Updated
- 2021/12/16
pluviatolide Chemical Properties,Usage,Production
Description
Pluviatolide is a lignan that has been found in B. chinense and has diverse biological activities, including antioxidant, enzyme inhibitory, and antispasmodic properties. It scavenges ABTS and 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals in cell-free assays (IC50s = 23.2 and 88.5 μM, respectively). Pluviatolide inhibits matrix metalloproteinase-7 (MMP-7) with an IC50 value of 260 μM. It decreases contractions induced by acetylcholine in isolated guinea pig ileum when used at concentrations of 30 and 100 μM.
Uses
Pluviatolide ((-)-Pluviatolide) is a lignan that can be found in the bark of Zanthoxylum pluviatile Hartley. Pluviatolide can be used as (-)-Podophyllotoxin precursor[1][2].
Definition
ChEBI: A butan-4-olide that is dihydrofuran-2(3H)-one which is substituted by a vanillyl group at position 3 and by a 3,4-methylenedioxybenzyl group at position 4 (the R,R stereoisomer).
References
[1] Corrie JET, et, al. The chemical constituents of Australian Zanthoxylum species. V. The constituents of Z. pluviatile Hartley; the structures of two new lignans. Australian Journal of Chemistry 23(1) 133-145.
[2] Decembrino D, et, al. Assembly of Plant Enzymes in E. coli for the Production of the Valuable (-)-Podophyllotoxin Precursor (-)-Pluviatolide. ACS Synth Biol. 2020 Nov 20;9(11):3091-3103. DOI:10.1021/acssynbio.0c00354
pluviatolide Preparation Products And Raw materials
Raw materials
Preparation Products
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