spisulosine
- Product Name
- spisulosine
- CAS No.
- 196497-48-0
- Chemical Name
- spisulosine
- Synonyms
- ES 285;spisulosine;Spisulosine 285;1-deoxysphinganine;2S-Amino-3R-octadecanol;1-deoxysphinganine (M18:0);3-Octadecanol, 2-amino-, (2S,3R)-;1-DEOXYSPHINGANINE (M18:0);1-DEOXYSPHINGANINE
- CBNumber
- CB51350936
- Molecular Formula
- C18H39NO
- Formula Weight
- 285.51
- MOL File
- 196497-48-0.mol
spisulosine Property
- Melting point:
- 115-116 °C
- Boiling point:
- 405.3±18.0 °C(Predicted)
- Density
- 0.871±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 10 mg/ml; DMSO: 2 mg/ml; Ethanol: miscible
- form
- A crystalline solid
- pka
- 12.90±0.45(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 13511
- Product name
- 1-Deoxysphinganine (m18:0)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 13511
- Product name
- 1-Deoxysphinganine (m18:0)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $521
- Updated
- 2024/03/01
- Product number
- 13511
- Product name
- 1-Deoxysphinganine (m18:0)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $923
- Updated
- 2024/03/01
- Product number
- 4282CR
- Product name
- Spisulosine
- Packaging
- 10mg
- Price
- $1126
- Updated
- 2021/12/16
- Product number
- 4282CR
- Product name
- Spisulosine
- Packaging
- 1mg
- Price
- $228
- Updated
- 2021/12/16
spisulosine Chemical Properties,Usage,Production
Uses
1-deoxysphinganine may be used for the complex preparation with bovine serum albumin for cytotoxicity testing in MN9D dopaminergic neuroblastoma cell line. It is also suitable for use as a neurotoxic agent in human CD8+ T cells.
Definition
ChEBI: 1-deoxysphinganine is a bioactive sphingoid, sphinganine, in which the terminal hydroxy group has been replaced by a hydrogen. It has a role as an antineoplastic agent. It is a sphingoid and an amino alcohol. It is functionally related to a sphinganine. It is a conjugate base of a 1-deoxysphinganine(1+).
Biological Activity
1-deoxysphinganine elicits cytotoxicity towards dorsal root ganglion (DRG) neurons by disrupting the neuronal cytoskeleton formation. High levels of 1-deoxysphinganine in diabetic patients may contribute to the reduction of pancreatic β cell functionality. In hereditary sensory and autonomic neuropathy type I, mutation in the serine palmitoyltransferase gene results in altered substrate specificity, resulting in the accumulation of 1-deoxysphinganine.
IC 50
PKCζ
spisulosine Preparation Products And Raw materials
Raw materials
Preparation Products
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