Hydroxyacetylaminofluorene
- Product Name
- Hydroxyacetylaminofluorene
- CAS No.
- 53-95-2
- Chemical Name
- Hydroxyacetylaminofluorene
- Synonyms
- N-Hydroxy-AAF;N-HYDROXY-2-AAF;Hydroxyacetylaminofluorene;N-hydroxy-2-acetamidofluorene;N-HYDROXY-2-ACETYLAMINOFLUORENE;2-(Acetylhydroxyamino)-9H-fluorene;N-HYDROXY-N-(2-FLUORENYL)ACETAMIDE;N-Fluoren-2-ylacetohydroxamic acid;N-Acetyl-N-2-fluorenylhydroxylamine;N-Hydroxy-2-acetylamino-9H-fluorene
- CBNumber
- CB51355542
- Molecular Formula
- C15H13NO2
- Formula Weight
- 239.27
- MOL File
- 53-95-2.mol
Hydroxyacetylaminofluorene Property
- Melting point:
- 140-143°C
- Boiling point:
- 381.93°C (rough estimate)
- Density
- 1.1198 (rough estimate)
- refractive index
- 1.5500 (estimate)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Light Yellow to Yellow
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- EPA Substance Registry System
- N-Hydroxy-2-acetylaminofluorene (53-95-2)
N-Bromosuccinimide Price
- Product number
- F462470
- Product name
- N-9H-Fluoren-2-yl-N-hydroxy-acetamide
- Packaging
- 10mg
- Price
- $230
- Updated
- 2021/12/16
- Product number
- FRL0000918
- Product name
- N-(9H-FLUOREN-2-YL)-N-[HYDROXY-ACETAMIDE]
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.11
- Updated
- 2021/12/16
Hydroxyacetylaminofluorene Chemical Properties,Usage,Production
Chemical Properties
cream powder
Chemical Properties
2-Acetylaminofl uorene is frequently used in the laboratory by biochemists and technicians as a positive control in the study of liver enzymes and the carcinogenicity and mutagenicity of aromatic amines. Exposure to 2-acetylaminofl uorene may occur via inhalation or dermal contact in laboratories where it is being used in the study of carcinogenesis. Occupations at greatest risk of exposure are organic chemists, chemical stockroom workers, and biomedical researchers.
Uses
N-9H-Fluoren-2-yl-N-hydroxy-acetamide inactivates human arylamine N-acetyltransferases (NATs), NAT1 and NAT2. Mutagenicity examined in Salmonella typhimurium TA1538. Liver produced metabolite of the cancinogen 2-Acetamidofluorene (A158535), which is also a highly carcinogenic compound.
Definition
ChEBI: N-hydroxy-2-acetamidofluorene is a member of 2-acetamidofluorenes.
General Description
Cream colored powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Hydroxyacetylaminofluorene is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition Hydroxyacetylaminofluorene emits toxic fumes of NOx.
Health Hazard
There is no complete information about the acute or chronic health effects of 2-acetylaminofl uorene in laboratory animals or in humans. However, oral exposures of 2-acetylaminofl uorene in laboratory mice caused moderate acute toxicity.
Fire Hazard
Flash point data for Hydroxyacetylaminofluorene are not available; however, Hydroxyacetylaminofluorene is probably combustible.