ChemicalBook > CAS DataBase List > SB 204990
SB 204990
- Product Name
- SB 204990
- CAS No.
- 154566-12-8
- Chemical Name
- SB 204990
- Synonyms
- SB 204990;SB-204990(racemic);SB 204990, 10 mM in DMSO;YTRNLFYTHYWDAU-KDOFPFPSSA-N;SB204990,Inhibitor,inhibit,ACLY,SB 204990,ATP Citrate Lyase,SB-204990;2-[(3S,5R)-5-[6-(2,4-dichlorophenyl)hexyl]-3-hydroxy-2-oxooxolan-3-yl]acetic acid;(3R,5S)-rel-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid;2-((3R,5S)-5-(6-(2,4-dichlorophenyl)hexyl)-3-hydroxy-2-oxotetrahydrofuran-3-yl)acetic acid;2-((3S,5R)-5-(6-(2,4-Dichlorophenyl)hexyl)-3-hydroxy-2-oxotetrahydrofuran-3-yl)acetic acid;3-Furanacetic acid, 5-[6-(2,4-dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-, (3R,5S)-rel-
- CBNumber
- CB51363884
- Molecular Formula
- C18H22Cl2O5
- Formula Weight
- 389.27
- MOL File
- 154566-12-8.mol
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SB 204990 Property
- Melting point:
- 87-89 °C
- Boiling point:
- 571.6±40.0 °C(Predicted)
- Density
- 1.332±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF: 30 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml
- form
- A crystalline solid
- pka
- 4.33±0.10(Predicted)
- color
- White to off-white
- InChI
- InChI=1/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,11-16(21)22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18+/s3
- InChIKey
- YTRNLFYTHYWDAU-RVFWCEGZNA-N
- SMILES
- O1[C@@H](CCCCCCC2=CC=C(Cl)C=C2Cl)C[C@@](O)(CC(O)=O)C1=O |&1:1,17,r|
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 15245
- Product name
- SB 204990
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 15245
- Product name
- SB 204990
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $111
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 15245
- Product name
- SB 204990
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $198
- Updated
- 2024/03/01
Tocris
- Product number
- 4962
- Product name
- SB204990
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $269
- Updated
- 2021/12/16
Tocris
- Product number
- 4962
- Product name
- SB204990
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $1091
- Updated
- 2021/12/16
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SB 204990 Chemical Properties,Usage,Production
Uses
SB 204990 is a prodrug of the potent ATP citrate-lyase inhibitor SB-201076.
Biological Activity
SB-204990 is a cell-permeable and orally available γ-lactone prodrug of the non-cell-permeable SB-201076 th at inhibits human and r at ATP citrate-lyase (Ki =1 μM against human and r at ACL) in a predominantly competitive manner with a small but significant uncompetitive component. SB-204990 treatment is shown to suppress the rate of cellular cholesterol and fatty acid synthesis in HepG2 cultures (by 91% & 82%, respectively, with 30 μM SB-204990), and display hypocholesterolaemic and hypolipidaemic efficacy in vivo when administered in the diet (0.05-0.25%, w/w; mice, rats, dogs).
storage
Store at -20°C
SB 204990 Preparation Products And Raw materials
Raw materials
Preparation Products
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