aspergillomarasmine A
- Product Name
- aspergillomarasmine A
- CAS No.
- 3484-65-9
- Chemical Name
- aspergillomarasmine A
- Synonyms
- aspergillomarasmine A;Toxin C (Pyrenophora teres);L-Aspartic acid, N-[(2S)-2-[[(2S)-2-amino-2-carboxyethyl]amino]-2-carboxyethyl]-
- CBNumber
- CB51366618
- Molecular Formula
- C10H17N3O8
- Formula Weight
- 307.26
- MOL File
- 3484-65-9.mol
aspergillomarasmine A Property
- Boiling point:
- 637.6±55.0 °C(Predicted)
- Density
- 1.579±0.06 g/cm3(Predicted)
- pka
- 2.12±0.23(Predicted)
N-Bromosuccinimide Price
- Product number
- INB0001911
- Product name
- ASPERGILLOMARASMINE A
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.03
- Updated
- 2021/12/16
aspergillomarasmine A Chemical Properties,Usage,Production
Uses
Aspergillomarasmine A is a natural aminopolycarboxylic acid with potent inhibitory activity against class B metallo-β-lactamases (MBLs). Aspergillomarasmine A inactivates MBLs by removing a catalytic Zn2+ cofactor. Aspergillomarasmine A acts as a selective Zn2+ scavenger, promoting the dissociation of the metal cofactor, thereby indirectly inactivating NDM-1. Aspergillomarasmine A causes the loss of Zn2+ ions from the low-affinity binding site of NDM-1. The action of Aspergillomarasmine A results in the rapid degradation of Zn2+-deficient NDM-1, thereby enhancing its potency as a β-lactam enhancer. The mechanism of Aspergillomarasmine A has broad applicability among different Zn2+ chelators[1].
Definition
ChEBI: Aspergillomarasmine A is an aspartic acid derivative.
References
[1] Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2
aspergillomarasmine A Preparation Products And Raw materials
Raw materials
Preparation Products
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