ChemicalBook > CAS DataBase List > 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDINE

4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDINE

Product Name
4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDINE
CAS No.
126352-69-0
Chemical Name
4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDINE
Synonyms
5-a]pyriMidine;7-tetrahydropyrazolo[1;4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine;4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDINE;1,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine;Pyrazolo[1,5-a]pyriMidine,4,5,6,7-tetrahydro-;4,5,6,7-Tetrahydropyrazolo[1,5-a]pyriMidine 2HCl;4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine(HCl salt);4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine hydrochloride
CBNumber
CB5136838
Molecular Formula
C6H9N3
Formula Weight
123.16
MOL File
126352-69-0.mol
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4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDINE Property

Boiling point:
290℃
Density 
1.33
Flash point:
129℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
4.52±0.20(Predicted)
Appearance
Off-white to yellow Solid
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN2811
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
T303908
Product name
4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine
Packaging
50mg
Price
$65
Updated
2021/12/16
AK Scientific
Product number
Y5255
Product name
4,5,6,7-Tetrahydropyrazolo[1,5-a]pyrimidine
Packaging
1g
Price
$358
Updated
2021/12/16
Matrix Scientific
Product number
069917
Product name
4,5,6,7-Tetrahydropyrazolo[1,5-a]pyrimidine
Purity
>95%
Packaging
1g
Price
$511
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
NUC0001853
Product name
4H,5H,6H,7H-PYRAZOLO[1,5-A]PYRIMIDINE
Purity
95.00%
Packaging
1G
Price
$699
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
NUC0001853
Product name
4H,5H,6H,7H-PYRAZOLO[1,5-A]PYRIMIDINE
Purity
95.00%
Packaging
2.5G
Price
$986
Updated
2021/12/16
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4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDINE Chemical Properties,Usage,Production

Uses

4,5,6,7-Tetrahydropyrazolo[1,5-a]pyrimidine can be used as FGFR inhibitors to treat FGFR3-associated diseases, such as, cancer.

Synthesis

1225387-53-0

109-64-8

126352-69-0

To a solution of 3H-pyrazol-3-amine (9.8 g, 0.1 mol) and triethylamine (TEA, 36.0 g, 0.3 mol) in 1,4-dioxane (200 mL) was added 1,3-dibromopropane (26.3 g, 0.1 mol). The reaction mixture was stirred at 110 °C for 5 hours. After the reaction was complete, the mixture was filtered. The filtrate was concentrated to dryness. The residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol = 100/1) to afford 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (5.3 g, yield: 36%) as a white solid.1H NMR (300 MHz, CDCl3): δ = 7.18 (s, 1H), 5.26 (s, 1H), 4.22-4.00 (m, 3H), 3.26-3.22 (m, 2H), 2.11-2.03 (m, 2H).

References

[1] Patent: WO2018/136890, 2018, A1. Location in patent: Paragraph 001018; 001019; 001020
[2] Bioorganic and Medicinal Chemistry, 1997, vol. 5, # 3, p. 557 - 567

4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDINE Suppliers

China 66 Germany 1 India 2 United States 9 Global 78
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Shangchem Co., Ltd.
Tel
+86-21-68182121
Fax
+86-21-68182121
Country
China
ProdList
882
Advantage
52
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
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62
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
ZEROSCHEM.CO.,LTD.
Tel
10-61256048 13810278579
Fax
+86 10 61256049
Email
sales@zeroschem.com
Country
China
ProdList
1370
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59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
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64
skychemical Co.Ltd
Tel
021-20958197 20965099
Fax
021-20960837
Email
sales@skychemical.com
Country
China
ProdList
1183
Advantage
57
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
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58
SynAsst Chemical.
Tel
021-60343070
Fax
021-35122006
Country
China
ProdList
12740
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55
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View Lastest Price from 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDINE manufacturers

Nanjing jinheyou Trading Co., Ltd.
Product
4,5,6,7-Tetrahydropyrazolo[1,5-a]pyrimidine 126352-69-0
Price
US $0.00/g
Min. Order
1g
Purity
95%min
Supply Ability
20kgs/month
Release date
2019-11-18
Nanjing jinheyou Trading Co., Ltd.
Product
4,5,6,7-Tetrahydropyrazolo[1,5-a]pyrimidine 126352-69-0
Price
US $0.00/g
Min. Order
1g
Purity
95%min
Supply Ability
30kgs/month
Release date
2019-11-14

126352-69-0, 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDINERelated Search:

5-(4-METHOXYPHENYL)-7-TRIFLUOROMETHYL-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXYLIC ACID 5-METHYL-7-TRIFLUOROMETHYL-4,5,6,7-TETRAHYDRO-PYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXYLIC ACID 5-PHENYL-7-TRIFLUOROMETHYL-4,5,6,7-TETRAHYDRO-PYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXYLIC ACID 3-CHLORO-5-PHENYL-7-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXYLIC ACID 5-BENZO[1,3]DIOXOL-5-YL-7-TRIFLUOROMETHYL-4,5,6,7-TETRAHYDRO-PYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXYLIC ACID AKOS B017957 2-(PYRROLIDIN-1-YLCARBONYL)-5-THIEN-2-YL-7-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDINE 1-{[3-CHLORO-5-THIEN-2-YL-7-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDIN-2-YL]CARBONYL}-1,2,3,4-TETRAHYDROQUINOLINE 3-BROMO-N-(2-FURYLMETHYL)-5-(4-METHOXYPHENYL)-7-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXAMIDE (3-CHLORO-5-(4-METHOXYPHENYL)-7-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDIN-2-YL)(4-PHENYLPIPERAZIN-1-YL)METHANONE (4-BENZHYDRYLPIPERAZIN-1-YL)(5-(3,4-DICHLOROPHENYL)-7-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDIN-2-YL)METHANONE 5-THIOPHEN-2-YL-7-TRIFLUOROMETHYL-4,5,6,7-TETRAHYD RO-PYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXYLIC ACID N-(PYRIDIN-3-YLMETHYL)-5-THIEN-2-YL-7-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE 5-(4-CHLORO-PHENYL)-7-TRIFLUOROMETHYL-4,5,6,7-TETRAHYDRO-PYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXYLIC ACID HYDRAZIDE 5-(4-CHLOROPHENYL)-N-[2-(METHYLTHIO)PHENYL]-7-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXAMIDE 3-CHLORO-N-CYCLOHEXYL-5-PHENYL-7-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXAMIDE AKOS B015127 5-(4-CHLORO-PHENYL)-7-TRIFLUOROMETHYL-4,5,6,7-TETRAHYDRO-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID ETHYL ESTER

  • 5-a]pyriMidine
  • 7-tetrahydropyrazolo[1
  • 4,5,6,7-Tetrahydropyrazolo[1,5-a]pyriMidine 2HCl
  • Pyrazolo[1,5-a]pyriMidine,4,5,6,7-tetrahydro-
  • 4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine
  • 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine hydrochloride
  • 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIMIDINE
  • 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine(HCl salt)
  • 1,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine
  • 126352-69-0
  • CHIRAL CHEMICALS