bigelovin
- Product Name
- bigelovin
- CAS No.
- 3668-14-2
- Chemical Name
- bigelovin
- Synonyms
- bigelovin;Bigelovin, 10 mM in DMSO;inhibit,Autophagy,Inhibitor,Retinoic acid receptors,Bigelovin,Retinoid X receptors,Apoptosis,Reactive Oxygen Species,RAR/RXR;Azuleno[6,5-b]furan-2,5-dione, 4-(acetyloxy)-3,3a,4,4a,7a,8,9,9a-octahydro-4a,8-dimethyl-3-methylene-, (3aR,4S,4aR,7aR,8R,9aS)-
- CBNumber
- CB51368728
- Molecular Formula
- C17H20O5
- Formula Weight
- 304.34
- MOL File
- 3668-14-2.mol
bigelovin Property
- Melting point:
- 180-182 °C(Solv: acetone (67-64-1); dichloromethane (75-09-2))
- Boiling point:
- 466.6±45.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-0065662
- Product name
- Bigelovin
- Packaging
- 5mg
- Price
- $280
- Updated
- 2021/12/16
bigelovin Chemical Properties,Usage,Production
Uses
Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation[1].
Definition
ChEBI: A sesquiterpene lactone that is 3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione substituted by methyl groups at positions 4a and 8, a methylidene group at position 3 and an acetoxy group at position 4. Isolated from Inula hupe ensis, it exhibits antineoplastic activity.
in vivo
Bigelovin (BigV, 5, 10, 20 mg/kg) exerts anti-tumor activity in HepG2 xenograft tumor model[1].
| Animal Model: | HepG2 xenograft model based on the male athymic BALB/c nude mice (5-6 weeks old, 18-22 g)[1]. |
| Dosage: | 5, 10, 20 mg/kg. |
| Administration: | Intravenous injection every 2 days. |
| Result: | The tumor growth rate was significantly slower in BigV treated groups in a dose-dependent manner, along with the reduced tumor weight. No significant alteration of body weight and hepatic enzyme levels (AST, ALT and LDH) in serum was observed after BigV administration. Western blot findings of tumor tissues indicated the activation of apoptosis and autophagy characterized by the increase of cleaved Caspase-3 and PARP, as well as LC3BII levels. The inactivation of mTOR was also observed in tumor tissues isolated from BigV-treated mice. |
References
[1] Bei Wang, et al. Bigelovin, a sesquiterpene lactone, suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation in liver cancer. Biochem Biophys Res Commun. 2018 May 5;499(2):156-163. DOI:10.1016/j.bbrc.2018.03.091
bigelovin Preparation Products And Raw materials
Raw materials
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View Lastest Price from bigelovin manufacturers
- Product
- bigelovin 3668-14-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20t
- Release date
- 2024-07-15