ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate

Product Name: ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate
CAS No.: 4450-98-0
Chemical Name: ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate
Synonyms: 1-Ebpc;CP-10668;Nsc 229530;Aldose Reductase,inhibit,EBPC,Inhibitor;1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester;1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester;2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylMethyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester;1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-, ethyl ester
CBNumber: CB51373216
Molecular Formula: C14H15NO4
Formula Weight: 261.27
MOL File: 4450-98-0.mol

More

Less

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Property

Melting point:: 135-136 °C
Boiling point:: 479.8±45.0 °C(Predicted)
Density: 1.340±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: ≥10mg/mL
form: white powder
pka: 4.50±1.00(Predicted)

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-41
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0140
Product name: EBPC
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $105
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0140
Product name: EBPC
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $505
Updated: 2024/03/01

Cayman Chemical

Product number: 14183
Product name: EBPC
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 14183
Product name: EBPC
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 14183
Product name: EBPC
Purity: ≥98%
Packaging: 10mg
Price: $139
Updated: 2024/03/01

More

Less

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Chemical Properties,Usage,Production

Description

The human aldose reductase AKR1B1 is considered the rate limiting enzyme of the polyol pathway responsible for the conversion of glucose into sorbitol. It also acts as a highly efficient PGF_2α synthase in response to interleukin-1β. Increased aldose reductase expression has been associated with complications of diabetes and may contribute to reduced efficacy of certain chemotherapeutic drugs. EBPC is a potent, selective inhibitor of aldose reductase with an IC₅₀ value of 47 nM in vitro. Through its regulation of glucose metabolism, EBPC has been used to improve the cytotoxic effects of the anticancer agents doxorubicin and cisplatin in HeLa cervical carcinoma cells. EBPC also inhibits prostaglandin F_2α (PGF_2α) and PGE₂ production in human endometrial cells with an EC₅₀ value of 10 μM.

Uses

A highly specific aldose reductase inhibitor that has been shown to enhance HeLa cell sensitivity to chemotherapeutic drugs.

Definition

ChEBI: Ethyl 1-benzyl-3-hydroxy- 2-oxo[5H]pyrrole-4-carboxylate is a pyrroline and a carboxylic acid.

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Suppliers

China 14 United Kingdom 1 United States 8 Global 23

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Tetranov Biopharm

Tel: 13526569071
Email: sales@leadmedpharm.com
Country: China
ProdList: 7905
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Changzhou Furuisi Biotechnology Co., Ltd

Tel: 0519-85524369
Email: 3477467573@qq.com
Country: China
ProdList: 8617
Advantage: 58

Jiaxing Zhejia Biotechnology Co., LTD

Tel: 0573-85609002
Email: zhejia01@163.com
Country: China
ProdList: 8871
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24647
Advantage: 58

Shanghai Haohong Scientific Co., Ltd.

Tel: 400-400-8210725
Email: malulu@leyan.com
Country: China
ProdList: 39990
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12005
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

4450-98-0, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylateRelated Search:

1-BENZYL-1,5-DIHYDRO-PYRROL-2-ONE Ethyl 3-(benzylamino)propanoate 1-Benzyl-2,5-dihydro-1H-pyrrole 1-(4-Methoxybenzyl)-3-hydroxy-4-ethoxycarbonyl-5-(3-pyridyl)-3-pyrrolin-2-one ETHYL 3-(N-BENZYL-N-METHYLAMINO)PROPANOATE 1-BENZYL-2,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLIC ACID METHYL ESTER ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate

1-Ebpc

1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-, ethyl ester

Nsc 229530

1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester

1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester

2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylMethyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester

CP-10668

Aldose Reductase,inhibit,EBPC,Inhibitor

4450-98-0

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pfizer Compounds

Pharmaceuticals