doxorubicin(6-maleimidocaproyl)hydrazone

Product Name: doxorubicin(6-maleimidocaproyl)hydrazone
CAS No.: 151038-96-9
Chemical Name: doxorubicin(6-maleimidocaproyl)hydrazone
Synonyms: DOXO-EMCH;INNO-206;MC-DOXHZN;Aldoxorubici;Doxorubicin-EMCH;MC DOXHZN,MCDOXHZN;INNO-206 (Aldoxorubicin);Doxorubicin-hydrazone-caproyl-maleimide;doxorubicin(6-maleimidocaproyl)hydrazone;DOXO-EMCH; DOXORUBICIN-EMCH; INNO206;INNO 206;ALDOXORUBICIN
CBNumber: CB51374839
Molecular Formula: C37H42N4O13
Formula Weight: 750.74838
MOL File: 151038-96-9.mol

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doxorubicin(6-maleimidocaproyl)hydrazone Property

Density: 1.60
solubility: Soluble in DMSO
pka: 7.38±0.60(Predicted)

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Safety

Safety Statements: 23-24/25

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A3372
Product name: DOXO-EMCH
Packaging: 2mg
Price: $113
Updated: 2021/12/16

ApexBio Technology

Product number: A3372
Product name: DOXO-EMCH
Packaging: 5mg
Price: $188
Updated: 2021/12/16

ApexBio Technology

Product number: A3372
Product name: DOXO-EMCH
Packaging: 10mg
Price: $255
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0005221
Product name: INNO-206
Purity: 95.00%
Packaging: 5MG
Price: $922.3
Updated: 2021/12/16

ApexBio Technology

Product number: A3372
Product name: DOXO-EMCH
Packaging: 50mg
Price: $960
Updated: 2021/12/16

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doxorubicin(6-maleimidocaproyl)hydrazone Chemical Properties,Usage,Production

Uses

Doxorubicin-hydrazone-caproyl-maleimide is an albumin-binding prodrug of doxorubicin and a promising clinical candidate for the treatment of a broad range of solid tumors

Biological Activity

the (6-maleimidocaproyl) hydrazone derivative of doxorubicin (inno-206), formerly known as doxo-emch, is a prodrug of the anticancer agent doxorubicin which selectively binds to the cys34 of circulating albumin and accumulates in solid tumors due to passive targeting[1]. inno-206 shows significantly superior antitumor efficacy over free doxorubicin in a spectrum of preclinical tumor models [2].

in vivo

in a murine renal cell carcinoma model and in breast carcinoma xenograft models, inno-206 has shown superior activity over doxorubicin. inno-206 has shown more potent antitumor efficacy than free doxorubicin in the tumor models and is thus a promising clinical candidate for treating a broad range of solid tumors [2].

References

[1]. kratz f. doxo-emch (inno-206): the first albumin-binding prodrug of doxorubicin to enter

doxorubicin(6-maleimidocaproyl)hydrazone Preparation Products And Raw materials

Raw materials

Preparation Products

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doxorubicin(6-maleimidocaproyl)hydrazone Suppliers

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View Lastest Price from doxorubicin(6-maleimidocaproyl)hydrazone manufacturers

Career Henan Chemical Co

Product: DOXO-EMCH 151038-96-9
Price: US $1.00/g
Min. Order: 1g
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-10

Career Henan Chemical Co

Product: doxorubicin(6-maleimidocaproyl)hydrazone 151038-96-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-10

151038-96-9, doxorubicin(6-maleimidocaproyl)hydrazoneRelated Search:

doxorubicin(6-maleimidocaproyl)hydrazone

(E)-N'-(1-((2R,4R)-4-((2S,4R,5R,6R)-4-aMino-5-hydroxy-6-Methyltetrahydro-2H-pyran-2-yloxy)-2,5,12-trihydroxy-7-Methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)-2-hydroxyethylidene)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide

INNO-206

INNO-206 (Aldoxorubicin)

DOXO-EMCH

Doxorubicin-EMCH

N'-[(1E)-1-{4-[(3-Amino-2,3,6-trideoxyhexopyranosyl)oxy]-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-2-tetracenyl}-2-hydroxyethylidene]-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexane hydrazide

MC-DOXHZN

DOXO-EMCH; DOXORUBICIN-EMCH; INNO206;INNO 206;ALDOXORUBICIN

1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, 2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide

Doxorubicin-hydrazone-caproyl-maleimide

1H-Pyrrole-1-hexanoicacid, 2,5-dihydro-2,5-dioxo-, [1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide

Aldoxorubici

MC DOXHZN,MCDOXHZN

151038-96-9

C37H42N4O13