camalexin

ChemicalBook > CAS DataBase List > camalexin

Product Name: camalexin
CAS No.: 135531-86-1
Chemical Name: camalexin
Synonyms: camalexin;Camalexine;Camalexin >=98% (HPLC);Camalexin, 10 mM in DMSO;2-(1H-indol-3-yl)thiazole;3-(Thiazol-2-yl)-1H-indole;1H-Indole, 3-(2-thiazolyl)-;2-(1H-indol-3-yl)-1,3-thiazole;3-(1,3-Thiazol-2-yl)-1H-indole;3-(1,3-Thiazol-2-yl)-1H-indole, camalexin
CBNumber: CB51384054
Molecular Formula: C11H8N2S
Formula Weight: 200.26
MOL File: 135531-86-1.mol

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camalexin Property

Boiling point:: 424.8±47.0 °C(Predicted)
Density: 1.336±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
pka: 15.49±0.30(Predicted)
form: powder
color: white to light brown

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36/37/39-45
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1016
Product name: Camalexin
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $88.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1016
Product name: Camalexin
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $476
Updated: 2024/03/01

Cayman Chemical

Product number: 21971
Product name: Camalexin
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21971
Product name: Camalexin
Purity: ≥98%
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 21971
Product name: Camalexin
Purity: ≥98%
Packaging: 10mg
Price: $122
Updated: 2024/03/01

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camalexin Chemical Properties,Usage,Production

Description

Camalexin is an alkaloid released by plants of the Brassicaceae family in response to pathogen infection. In addition to antimicrobial properties and a role in plant defense, camalexin exhibits antiproliferative activity in vitro against various cancer cell lines. Camalexin is active against HeLa, Jurkat, MDA-MB-231, and CEM cancer cell lines (IC₅₀s = 50.0, 46.2, 77.7, and 67.6 μM, respectively), but it is also toxic to primary human umbilical vein endothelial cells (HUVEC; (IC₅₀ = 74.0 μM). Camalexin induces apoptosis in Jurkat cells by increasing reactive oxygen species (ROS) levels and activating caspase-8 and caspase-9. In human prostate cancer cell lines, camalexin (25 μM) is more active against aggressive lines and increases ROS levels and apoptosis via cathepsin D relocation from lysosomes to the cytosol.

Uses

Camalexin has been used in quantification and tolerance assays in Arabidopsis thaliana leaves.

Definition

ChEBI: An indole phytoalexin that is indole substituted at position 3 by a 1,3-thiazol-2-yl group.

Synthesis Reference(s)

Tetrahedron, 51, p. 773, 1995 DOI: 10.1016/0040-4020(94)00987-6

Biochem/physiol Actions

Camalexin is a phytoalexin isolated from cruciferous plants that exhibits antibacterial, antifungal, antiproliferative and cancer chemopreventive activities. Apparently, camalexin increases the ROS levels and is more effective in aggressive prostate cancer cells that express high ROS levels. In Arabidopsis thaliana, camalexin and salicylic acid confer resistance to Phytophthora capsici.

camalexin Preparation Products And Raw materials

Raw materials

Preparation Products

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135531-86-1, camalexinRelated Search:

camalexin

3-(Thiazol-2-yl)-1H-indole

Camalexine

1H-Indole, 3-(2-thiazolyl)-

Camalexin >=98% (HPLC)

3-(1,3-Thiazol-2-yl)-1H-indole, camalexin

3-(1,3-Thiazol-2-yl)-1H-indole

Phytoalexin,antifungal,Camalexin,antiproliferative,Bacterial,anticancer,ROS,Fungal,Inhibitor,Reactive Oxygen Species,inhibit,antibacterial,cruciferous

2-(1H-indol-3-yl)-1,3-thiazole

2-(1H-indol-3-yl)thiazole

Camalexin, 10 mM in DMSO

135531-86-1

35531-86-1