ChemicalBook > CAS DataBase List > FPL 62064

FPL 62064

Product Name
FPL 62064
CAS No.
103141-09-9
Chemical Name
FPL 62064
Synonyms
FPL 62064;FPL 62064, 10 mM in DMSO;N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine;1H-Pyrazol-3-amine,N-(4-methoxyphenyl)-1-phenyl-;Cyclooxygenase,FPL 62064,LOX,5-lipoxygenase,FPL62064,inhibit,FPL-62064,Prostaglandin,5-LOX,COX,Inhibitor,synthetase,Lipoxygenase,anti-inflammatory,COX-2
CBNumber
CB51384847
Molecular Formula
C16H15N3O
Formula Weight
265.31
MOL File
103141-09-9.mol
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FPL 62064 Property

Boiling point:
442.6±25.0 °C(Predicted)
Density 
1.15±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO: 250 mg/mL (942.29 mM)
pka
2.42±0.50(Predicted)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M350460
Product name
N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
M350460
Product name
N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine
Packaging
100mg
Price
$240
Updated
2021/12/16
AK Scientific
Product number
3655AL
Product name
N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine
Packaging
10mg
Price
$149
Updated
2021/12/16
AK Scientific
Product number
3655AL
Product name
N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine
Packaging
100mg
Price
$298
Updated
2021/12/16
ChemScene
Product number
CS-0024722
Product name
FPL62064
Purity
98.46%
Packaging
5mg
Price
$350
Updated
2021/12/16
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FPL 62064 Chemical Properties,Usage,Production

Uses

FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC50 values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity[1][2].

in vivo

FPL 62064 (5-20 mg/kg; intraperitoneal injection; female LACA mice) treatment inhibits peritoneal inflammation induced by immune-complex[1].

Animal Model:Female LACA mice (20-30 g) injected with immune complex[1].
Dosage:5 mg/kg, 10 mg/kg, 20 mg/kg
Administration:Intraperitoneal injection
Result:Produced a dose-related inhibition of dye extravasation, leukotriene C4 (LTC4) and prostaglandin E2 (PGE2) formation.

References

[1] Blackham A, et al. FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor. Agents Actions. 1990 Jun;30(3-4):432-42. DOI:10.1007/BF01966309
[2] Shabaan MA, et al. Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase. Arch Pharm (Weinheim). 2020 Feb 7:e1900308. DOI:10.1002/ardp.201900308

FPL 62064 Preparation Products And Raw materials

Raw materials

Preparation Products

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FPL 62064 Suppliers

China 41 India 1 United States 6 Global 48
Hotechem Shanghai Co., Ltd.,
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025-58859352 13155353615
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103141-09-9, FPL 62064Related Search:

FORMANILIDE Acetanilide

  • 1H-Pyrazol-3-amine,N-(4-methoxyphenyl)-1-phenyl-
  • FPL 62064
  • N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine
  • Cyclooxygenase,FPL 62064,LOX,5-lipoxygenase,FPL62064,inhibit,FPL-62064,Prostaglandin,5-LOX,COX,Inhibitor,synthetase,Lipoxygenase,anti-inflammatory,COX-2
  • FPL 62064, 10 mM in DMSO
  • 103141-09-9