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AS 35

Product Name
AS 35
CAS No.
108427-72-1
Chemical Name
AS 35
Synonyms
AS 35;AS 35,AS35;4H-Pyrido[1,2-a]pyrimidin-4-one, 9-[(4-acetyl-3-hydroxy-2-propylphenoxy)methyl]-3-(2H-tetrazol-5-yl)-;3-(1H-Tetrazol-5-yl)-9-[[[2-propyl-3-hydroxy-4-(methylcarbonyl)phenyl]oxy]methyl]-4H-pyrido[1,2-a]pyrimidin-4-one
CBNumber
CB51385475
Molecular Formula
C21H20N6O4
Formula Weight
420.42
MOL File
108427-72-1.mol
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AS 35 Property

Melting point:
269-271 °C
Boiling point:
678.8±65.0 °C(Predicted)
Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
3?+-.0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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AS 35 Chemical Properties,Usage,Production

Uses

AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC50 values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities.

in vivo

AS-35 (0.0375 to 0.3 mg/kg, i.v.) dose-dependently antagonizes bronchoconstriction induced by i.v.-injection of LTC4 and LTD4 in anesthetized guinea pigs, but does not inhibit histamine-induced bronchoconstriction. Oral administration of AS-35 also antagonizes LTD4 as well as antigen-induced LT-mediated bronchoconstriction. AS-35 (p.o.) inhibits LTD4-induced increase in the cutaneous vascular permeability of guinea pig[1].

IC 50

LTE4: 3 nM (IC50, In isolated guinea pig ileum); LTD4: 4 nM (IC50, In isolated guinea pig ileum); LTC4: 8 nM (IC50, In isolated guinea pig ileum)

References

[1] Kasai H, et al. Peptide leukotriene antagonistic activity of AS-35, a new antiallergic drug. Jpn J Pharmacol. 1992 Apr;58(4):347-55. DOI:10.1254/jjp.58.347

AS 35 Preparation Products And Raw materials

Raw materials

Preparation Products

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AS 35 Suppliers

China 5 South Korea 1 United States 5 Global 11
BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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United States
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Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
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liming@bio-fount.com
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China
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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32435
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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China
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
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customer_service@efebio.com
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China
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Biosynth Biological Technology (Suzhou) Co Ltd
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51288865780
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sales@biosynth.com
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Adooq Bioscience LLC
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400-025-6535
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sales@adooq.cn
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China
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TargetMol Chemicals Inc.
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+1-781-999-5354;
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support@targetmol.com
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United States
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39035
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108427-72-1, AS 35Related Search:

PEMIROLAST AKOS BC-1944 4-[3-(Dimethylamino)propoxy]benzaldehyde Dimethallylamine AS 35 4-[(2-METHYL-2-PROPEN-1-YL)OXY]BENZALDEHYDE

  • AS 35
  • 3-(1H-Tetrazol-5-yl)-9-[[[2-propyl-3-hydroxy-4-(methylcarbonyl)phenyl]oxy]methyl]-4H-pyrido[1,2-a]pyrimidin-4-one
  • 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-[(4-acetyl-3-hydroxy-2-propylphenoxy)methyl]-3-(2H-tetrazol-5-yl)-
  • AS 35,AS35
  • 108427-72-1