4-(1H-tetrazol-5-yl)-N-(4-(1H-tetrazol-5-yl)phenyl)benzamide

Product Name: 4-(1H-tetrazol-5-yl)-N-(4-(1H-tetrazol-5-yl)phenyl)benzamide
CAS No.: 132640-22-3
Chemical Name: 4-(1H-tetrazol-5-yl)-N-(4-(1H-tetrazol-5-yl)phenyl)benzamide
Synonyms: CR2039;CR-2039;CR 2039;Dizolast);Andolast free base;Andolast (Synonyms: CR 2039;4-(1H-tetrazol-5-yl)-N-(4-(1H-tetrazol-5-yl)phenyl)benzamide;Benzamide, 4-(2H-tetrazol-5-yl)-N-[4-(2H-tetrazol-5-yl)phenyl]-
CBNumber: CB51391117
Molecular Formula: C15H11N9O
Formula Weight: 333.31
MOL File: 132640-22-3.mol

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4-(1H-tetrazol-5-yl)-N-(4-(1H-tetrazol-5-yl)phenyl)benzamide Property

Density: 1.551±0.06 g/cm3(Predicted)
pka: 3.78±0.10(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0010712
Product name: ANDOLAST
Purity: 95.00%
Packaging: 5MG
Price: $505.53
Updated: 2021/12/16

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4-(1H-tetrazol-5-yl)-N-(4-(1H-tetrazol-5-yl)phenyl)benzamide Chemical Properties,Usage,Production

Uses

Andolast (CR 2039) (free base) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for the research of asthma[1].

in vivo

Andolast (CR 2039) (i.v. or i.m.) inhibits rat passive cutaneous anaphylaxis (PCA) with an ED₅₀ of 0.1 mg/kg^[1].
CR 2039 (10-100 mg/kg; i.v. or i.m.) inhibits the microvascular permeability changes in a model of allergic conjunctivitis in sensitized guinea-pigs^[1].
CR 2039 (0-1000 μM; i.v.) inhibits dose dependently guinea-pig lung cAMP-phosphodiesterase with an IC₅₀ value of 50 μM^[1].

Animal Model:	Male Hartley guinea-pigs (300-500 g) ^[1]
Dosage:	10-100 mg/kg
Administration:	I.M; I.V.
Result:	Showed dose-related significant protection against lgE-dependent bronchial anaphylaxis induced by aerosolized antigen in anesthetized guinea-pigs. Delayed dose dependently the onset of bronchoconstriction induced by aerosolized antigen.

References

[1] Revel L, Colombo S, Ferrari F, Folco G, Rovati LC, Makovec F. CR 2039, a new bis-(1H-tetrazol-5-yl)phenylbenzamide derivative with potential for the topical treatment of asthma. Eur J Pharmacol. 1992;229(1):45-53. DOI:10.1016/0014-2999(92)90284-b
[2] Czuczwar SJ, Gasior M, Kozicka M, Pietrasiewicz T, Turski WA, Kleinrok Z. A potential anti-asthmatic drug, CR 2039, enhances the anticonvulsive activity of some antiepileptic drugs against pentetrazol in mice. Eur Neuropsychopharmacol. 1998;8(3):233-238. DOI:10.1016/s0924-977x(97)00077-1

4-(1H-tetrazol-5-yl)-N-(4-(1H-tetrazol-5-yl)phenyl)benzamide Preparation Products And Raw materials

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Preparation Products

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4-(1H-tetrazol-5-yl)-N-(4-(1H-tetrazol-5-yl)phenyl)benzamide Suppliers

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Shanghai Boyle Chemical Co., Ltd.

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132640-22-3, 4-(1H-tetrazol-5-yl)-N-(4-(1H-tetrazol-5-yl)phenyl)benzamideRelated Search:

4-(1H-tetrazol-5-yl)-N-(4-(1H-tetrazol-5-yl)phenyl)benzamide 3-(ISOPROPOXYCARBONYL)PHENYLBORONIC ACID 4-(1H-TETRAZOL-5-YL)BENZALDEHYDE 4-(2H-TETRAZOL-5-YL)-PHENYLAMINE

4-(1H-tetrazol-5-yl)-N-(4-(1H-tetrazol-5-yl)phenyl)benzamide

Benzamide, 4-(2H-tetrazol-5-yl)-N-[4-(2H-tetrazol-5-yl)phenyl]-

Andolast (Synonyms: CR 2039

Dizolast)

CR 2039

CR2039

CR-2039

Andolast free base

132640-22-3