L-Lysine, glycyl-L-lysyl-L-cysteinyl-L-seryl-L-threonyl-L-arginylglycyl-L-arginyl-L-lysyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-arginyl-L-lysyl-

Product Name: L-Lysine, glycyl-L-lysyl-L-cysteinyl-L-seryl-L-threonyl-L-arginylglycyl-L-arginyl-L-lysyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-arginyl-L-lysyl-
CAS No.: 1403753-45-6
Chemical Name: L-Lysine, glycyl-L-lysyl-L-cysteinyl-L-seryl-L-threonyl-L-arginylglycyl-L-arginyl-L-lysyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-arginyl-L-lysyl-
Synonyms: SAP15;L-Lysine, glycyl-L-lysyl-L-cysteinyl-L-seryl-L-threonyl-L-arginylglycyl-L-arginyl-L-lysyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-arginyl-L-lysyl-
CBNumber: CB513971297
Molecular Formula: C68H131N31O18S3
Formula Weight: 1767.17
MOL File: 1403753-45-6.mol

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L-Lysine, glycyl-L-lysyl-L-cysteinyl-L-seryl-L-threonyl-L-arginylglycyl-L-arginyl-L-lysyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-arginyl-L-lysyl- Property

Density: 1.55±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
Sequence: Gly-Lys-Cys-Ser-Thr-Arg-Gly-Arg-Lys-Cys-Cys-Arg-Arg-Lys-Lys

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Hazard and Precautionary Statements (GHS)

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L-Lysine, glycyl-L-lysyl-L-cysteinyl-L-seryl-L-threonyl-L-arginylglycyl-L-arginyl-L-lysyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-arginyl-L-lysyl- Chemical Properties,Usage,Production

Uses

SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic anti-inflammatory peptide consisting of 15 amino acids designed from human beta-defensin 3. SAP15 has the ability to penetrate cells and is able to induce downregulation of intracellular inflammation. SAP15 inhibits inflammation by inhibiting the phosphorylation of HDAC5 and thereby reducing the phosphorylation of NF-κB p65. In LPS-induced macrophages, SAP15 inhibits HDAC5 and NF-κB p65 phosphorylation. In addition, SAP15 treatment increased the expression of aggrecan and type II collagen and decreased the expression of osteocalcin in LPS-induced chondrocytes. SAP15 can be used in the study of inflammation regulation and anti-inflammatory therapy of biomaterials[1].

References

[1] Lee J Y, et al. Engineered synthetic cell penetrating peptide with intracellular anti‐inflammatory bioactivity: An in vitro and in vivo study[J]. Journal of Biomedical Materials Research Part A, 2021, 109(10): 2001-2016. DOI:10.1002/jbm.a.37192

L-Lysine, glycyl-L-lysyl-L-cysteinyl-L-seryl-L-threonyl-L-arginylglycyl-L-arginyl-L-lysyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-arginyl-L-lysyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Lysine, glycyl-L-lysyl-L-cysteinyl-L-seryl-L-threonyl-L-arginylglycyl-L-arginyl-L-lysyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-arginyl-L-lysyl- Suppliers

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1403753-45-6, L-Lysine, glycyl-L-lysyl-L-cysteinyl-L-seryl-L-threonyl-L-arginylglycyl-L-arginyl-L-lysyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-arginyl-L-lysyl-Related Search:

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L-Lysine, glycyl-L-lysyl-L-cysteinyl-L-seryl-L-threonyl-L-arginylglycyl-L-arginyl-L-lysyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-arginyl-L-lysyl-

SAP15

1403753-45-6