simvastatin acid

Product Name: simvastatin acid
CAS No.: 121009-77-6
Chemical Name: simvastatin acid
Synonyms: Tenivastatin;Simvastatin acid;Simvastatin hydroxy acid;Benazolin-ethyl Impurity 14;Simvastatin Acid (Tenivastatin);Tenivastatincalcium Salt impurity (OR) Simvastatin impurity A;Simvastatin Acid D6Q: What is Simvastatin Acid D6 Q: What is the CAS Number of Simvastatin Acid D6;(βR,δR,1S)-8α-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8aβ-hexahydro-β,δ-dihydroxy-2β,6α-dimethyl-1β-naphthaleneheptanoic acid;(3R,5R)-3,5-Dihydroxy-7-[(1S)-1-(2,2-dimethylbutyryloxy)-3β,7α-dimethyl-1,2,3,7,8,8aα-hexahydronaphthalene-8α-yl]heptanoic acid;2,2-Dimethylbutyric acid (1S)-3β,7α-dimethyl-8α-[(3R,5R)-3,5-dihydroxy-6-carboxyhexyl]-1,2,3,7,8,8aα-hexahydronaphthalene-1β-yl ester
CBNumber: CB51398181
Molecular Formula: C25H40O6
Formula Weight: 436.585
MOL File: 121009-77-6.mol

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simvastatin acid Property

Boiling point:: 607.0±55.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
pka: 4.31±0.10(Predicted)
EPA Substance Registry System: 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-?,?-dihydroxy-2,6-dimethyl-, (?R,?R,1S,2S,6R,8S,8aR)- (121009-77-6)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0027279
Product name: SIMVASTATIN IMPURITY-A
Purity: 95.00%
Packaging: 5MG
Price: $504.57
Updated: 2021/12/16

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simvastatin acid Chemical Properties,Usage,Production

Uses

Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin (HY-17502), is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].

Definition

ChEBI: Simvastatin hydroxy acid is a carbonyl compound.

References

[1] Eduardo Filipe Oliveira, et al. HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015). Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DOI:10.1080/13543776.2016.1216977
[2] Atilano-Roque A, et al. Characterization of simvastatin acid uptake by organic anion transporting polypeptide 3A1 (OATP3A1) and influence of drug-drug interaction. Toxicol In Vitro. 2017 Dec;45(Pt 1):158-165. DOI:10.1016/j.tiv.2017.09.002

simvastatin acid Preparation Products And Raw materials

Raw materials

Preparation Products

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simvastatin acid Suppliers

China 14 India 3 United States 1 Global 18

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-0755-28967200-8062 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9624
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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Nanjing Shizhou Biology Technology Co.,Ltd

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Email: sean.lv@synzest.com
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TCI (Shanghai) Chemical Trading Co., Ltd.

Tel: 021-61109150
Fax: 021-61105897
Email: sales@tcisct.com
Country: China
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Zhuhai Anzhe Biotechnology Co,Ltd.

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Country: China
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QUALITY CONTROL SOLUTIONS LTD.

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Email: export03@qcsrm.com
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TargetMol Chemicals Inc.

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Country: China
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Shanghai Saikerui Biotechnology Co. , Ltd.

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Shanghai Yifei Biotechnology Co. , Ltd.

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Nanjing Shizhou Biology Technology Co.,Ltd

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121009-77-6, simvastatin acidRelated Search:

Simvastatin SIMVASTATIN, SODIUM SALT SIMVASTATIN ACID, SODIUM SALT [3H(G)] 6'-HYDROXYCARBOXY SIMVASTATIN ACID DISODIUM SALT 6'-HYDROXYMETHYL SIMVASTATIN ACID SODIUM SALT SIMVASTATIN HYDROXY ACID SODIUM SALT-D6 simvastatin acid 3''-HYDROXY SIMVASTATIN ACID SODIUM SALT Simvastatin ammonium salt SIMVASTATIN-D6 HYDROXY ACID, AMMONIUM SALT

(3R,5R)-3,5-Dihydroxy-7-[(1S)-1-(2,2-dimethylbutyryloxy)-3β,7α-dimethyl-1,2,3,7,8,8aα-hexahydronaphthalene-8α-yl]heptanoic acid

(βR,δR,1S)-8α-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8aβ-hexahydro-β,δ-dihydroxy-2β,6α-dimethyl-1β-naphthaleneheptanoic acid

2,2-Dimethylbutanoic acid [(1S)-1,2,3,7,8,8aα-hexahydro-3β,7α-dimethyl-8α-[(3R,5R)-3,5-dihydroxy-6-carboxyhexyl]naphthalen]-1β-yl ester

2,2-Dimethylbutyric acid (1S)-3β,7α-dimethyl-8α-[(3R,5R)-3,5-dihydroxy-6-carboxyhexyl]-1,2,3,7,8,8aα-hexahydronaphthalene-1β-yl ester

Simvastatin hydroxy acid

(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid

1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, (βR,δR,1S,2S,6R,8S,8aR)-

Tenivastatin

(3R,5R)-7-{(1S,2S,6R,8S,8aR)-8-[(2,2-Dimethylbutanoyl)oxy]-2,6-di methyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl}-3,5-dihydroxyheptan oic acid

Simvastatin Acid D6Q: What is Simvastatin Acid D6 Q: What is the CAS Number of Simvastatin Acid D6

(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid (tenivastatin)

(1S,3R,7S,8S,8aR)-3,7-dimethyl-8-[2-[(2R)-6-oxo-3,6-dihydro-2H-pyran-2-yl]ethyl]-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate

Simvastatin Acid (Tenivastatin)

Simvastatin acid

Benazolin-ethyl Impurity 14

Tenivastatincalcium Salt impurity (OR) Simvastatin impurity A

121009-77-6