6-(4-Fluorophenyl)-picolinic acid

Product Name: 6-(4-Fluorophenyl)-picolinic acid
CAS No.: 863704-60-3
Chemical Name: 6-(4-Fluorophenyl)-picolinic acid
Synonyms: 6-(4-Fluorophenyl);6-(4-Fluorophenyl)-picolinic acid;6-(4-Fluorophenyl)-2-pyridinecarboxylic acid;2-Pyridinecarboxylic acid, 6-(4-fluorophenyl)-
CBNumber: CB51455662
Molecular Formula: C12H8FNO2
Formula Weight: 217.2
MOL File: 863704-60-3.mol

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6-(4-Fluorophenyl)-picolinic acid Property

Boiling point:: 404.9±35.0 °C(Predicted)
Density: 1.318±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 4.67±0.25(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F621265
Product name: 6-(4-Fluorophenyl)picolinicacid
Packaging: 25mg
Price: $45
Updated: 2021/12/16

TRC

Product number: F621265
Product name: 6-(4-Fluorophenyl)picolinicacid
Packaging: 100mg
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: V8189
Product name: 6-(4-Fluorophenyl)picolinicacid
Packaging: 1g
Price: $277
Updated: 2021/12/16

Matrix Scientific

Product number: 082406
Product name: 6-(4-Fluorophenyl)pyridine-2-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $617
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0070118
Product name: 6-(4-FLUOROPHENYL)PYRIDINE-2-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 1G
Price: $1819.13
Updated: 2021/12/16

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6-(4-Fluorophenyl)-picolinic acid Chemical Properties,Usage,Production

Uses

6-(4-Fluorophenyl)picolinic acid

Synthesis

21190-87-4

225916-39-2

863704-60-3

General procedure for the synthesis of 6-(4-fluorophenyl)pyridine carboxylic acid from 6-bromo-2-pyridine carboxylic acid and 4-fluorophenylboronic acid neopentyl glycol ester: A) 6-bromopyridine carboxylic acid (2.02 g, 10 mmol) was dissolved in DME containing 4 mL of 10% Na2CO3 aqueous solution under argon protection. To this solution was added Pd(PPh3)4 followed by 2-(4-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborolane (2.40 g, 11.5 mmol) and EtOH (20 mL) and the mixture was purged under argon protection. The reaction mixture was heated in a sealed tube at 100 °C for 2.5 hours. After that, additional 6-bromopyridinecarboxylic acid (900 mg) and Pd(OAc)2 were added, and after purging again with argon, heating was continued at 100 °C for 4.5 hours. Upon completion of the reaction, trifluoroacetic acid (20 mL) was added to the mixture, the reaction solution was concentrated and MeOH (150 mL) was added to the residue. The insoluble material was removed by filtration and the filtrate was concentrated. Purification by silica gel fast column chromatography using EtOAc/MeOH (900:100) and EtOAc/MeOH/HOAc (700:1500:50) sequentially as eluents afforded the target product 6-(4-fluorophenyl)pyridinecarboxylic acid (1.0 g, 40% yield, based on borate feedstock) as a white solid.1H NMR (CD3OD) δ 8.01 (d, 1H, J = 7.7 Hz), 7.94-7.87 (m, 3H), 7.73 (d, 1H, J = 7.7 Hz), 7.13 (t, 2H, J = 8.8 Hz); MS (ESI+) m/z 234 (M + H)+.

References

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 17, p. 5330 - 5341
[2] Patent: US2007/60613, 2007, A1. Location in patent: Page/Page column 18-19

6-(4-Fluorophenyl)-picolinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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6-(4-Fluorophenyl)-picolinic acid Suppliers

China 22 India 1 United States 6 Global 29

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863704-60-3, 6-(4-Fluorophenyl)-picolinic acidRelated Search:

6-(4-Fluorophenyl)

6-(4-Fluorophenyl)-picolinic acid

2-Pyridinecarboxylic acid, 6-(4-fluorophenyl)-

6-(4-Fluorophenyl)-2-pyridinecarboxylic acid

863704-60-3