ChemicalBook > CAS DataBase List > Ilaprazole

Ilaprazole

Product Name: Ilaprazole
CAS No.: 172152-36-2
Chemical Name: Ilaprazole
Synonyms: Ilaprazole(IY 81149);laprazole;IY 81149;Oprazole;Ilaprazole;Blue Forest;Ilaprazole USP/EP/BP;Ilaprazole, 10 mM in DMSO;IY81149; IY-81149; IY 81149;2-[(4-methoxy-3-methyl-pyridin-2-yl)methylsulfinyl]-5-pyrrol...
CBNumber: CB51459367
Molecular Formula: C19H18N4O2S
Formula Weight: 366.44
MOL File: 172152-36-2.mol

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Ilaprazole Property

Boiling point:: 651.0±65.0 °C(Predicted)
Density: 1.39
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMF: 10mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:7): 0.12mg/mL; Ethanol: 0.3mg/mL
form: A solid
pka: 8.23±0.10(Predicted)
color: Off-white to gray
InChI: InChI=1S/C19H18N4O2S/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23/h3-11H,12H2,1-2H3,(H,21,22)
InChIKey: HRRXCXABAPSOCP-UHFFFAOYSA-N
SMILES: C1(S(CC2=NC=CC(OC)=C2C)=O)NC2=CC(N3C=CC=C3)=CC=C2N=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2322
Product name: Ilaprazole
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $99
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2322
Product name: Ilaprazole
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $391
Updated: 2025/07/31

TCI Chemical

Product number: I1191
Product name: Ilaprazole
Packaging: 250MG
Price: $124
Updated: 2025/07/31

TCI Chemical

Product number: I1191
Product name: Ilaprazole
Packaging: 1G
Price: $311
Updated: 2025/07/31

Cayman Chemical

Product number: 30120
Product name: Ilaprazole
Packaging: 5mg
Price: $110
Updated: 2024/03/01

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Ilaprazole Chemical Properties,Usage,Production

Description

Ilaprazole is a substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. A weak base, ilaprazole accumulates in the acidic environment of the secretory canaliculus of the gastric parietal cell where it is converted to an active sulfenamide form that binds to cysteine sulfhydryl groups on the luminal aspect of the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production.

Uses

Ilaprazole is a proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer.

Definition

ChEBI: Ilaprazole is a sulfoxide and a member of benzimidazoles.

in vivo

Ilaprazole (3-30 mg/kg; i.d.) dose-dependently inhibits gastric acid secretion^[1].
In anesthetized rats, Ilaprazole dose-dependently increased gastric pH which was lowered by histamine infusion. In the case of i.v. injection, the ED₅₀ of Ilaprazole and omeprazole is 1.2 and 1.4 mg/kg and in the case of i.d. administration, the ED₅₀ of Ilaprazole and omeprazole is 3.9 and 4.1 mg/kg, respectively. Ilaprazole also significantly inhibits pentagastrin-stimulated gastric secretion. Its ED₅₀ is 2.1 mg/kg and that of Omeprazole is 3.5 mg/kg with i.d. administration. In the case of i.v. injection, Ilaprazole is equipotent to Omeprazole. Ilaprazole also inhibits gastric acid secretion strongly in fistular rats. The ED₅₀ of Ilaprazole administered intraduodenally is 0.43 mg/kg and that of Omeprazole is 0.68 mg/kg^[1].

Animal Model:	Male SD rat (after pylorus ligation)^[1]
Dosage:	3, 10, 30 mg/kg
Administration:	Intraduodenally
Result:	The acid output and volume significantly inhibited by about 60 % and 46 % at 3 mg/kg were s, respectively. At 30 mg/kg, it showed 93 % and 73 % inhibition on acid output and volume, respectively.

Ilaprazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ilaprazole manufacturers

Wuhan JiyunZen Tech Co., Ltd.

Product: Ilaprazole 172152-36-2
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-06-05

Shaanxi Dideu New Materials Co. Ltd

Product: Ilaprazole 172152-36-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-05-16

Zibo Wei Bin Import & Export Trade Co. Ltd.

Product: Ilaprazole 172152-36-2
Price: US $1.00/kg
Min. Order: 0.1kg
Purity: 98%
Supply Ability: 50kg
Release date: 2023-12-08

172152-36-2, IlaprazoleRelated Search:

Itopride BISMUTH POTASSIUM CITRATE Omeprazole magnesium Iguratimod L-Glutamine Tolvaptan CINITAPRIDE HYDROGEN TARTRATE Esomeprazole R-(+)-Lansoprazole 2-PYRIMIDINAMINE, 4-(3,4-DIHYDRO-1-METHYL-2(1H)-ISOQUINOLINYL)-N-(4-FLUOROPHENYL)-5,6-DIMETHYL-, MONOHYDROCHLORIDE Pantoprazole Lansoprazole Omeprazole Ilaprazole Timoprazole 5-Amino-2-benzimidazolethiol 2,3-DIMETHYLISONICOTINALDEHYDE 2-[(4-METHOXY-3-METHYL-2-PYRIDINYL)-METHYLTHIO]-BENZIMIDAZOLE

2-[(4-methoxy-3-methyl-pyridin-2-yl)methylsulfinyl]-5-pyrrol-1-yl-3H-benzoimidazole

2-[[(4-Methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-1H-benzimidazole

IY 81149

Ilaprazole(IY 81149)

1H-BenziMidazole,2-[[(4-Methoxy-3-Methyl-2-pyridinyl)Methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-

2-[(4-methoxy-3-methylpyridin-2-yl)methylsulfinyl]-6-pyrrol-1-yl-1H-benzimidazole

IY81149; IY-81149; IY 81149

Ilaprazole USP/EP/BP

2-[(4-methoxy-3-methyl-pyridin-2-yl)methylsulfinyl]-5-pyrrol-1-yl-3H-benzoimidazole USP/EP/BP

2-[[(4-Methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]5-(1H-pyrrol-1-yl) 1H benzimidazole

2-(((4-Methoxy-3-methylpyridin-2-yl)methyl)sulfinyl)-6-(1H-pyrrol-1-yl)-1H-benzo[d]imidazole

2-[(4-methoxy-3-methyl-pyridin-2-yl)methylsulfinyl]-5-pyrrol...

IlaprazoleQ: What is Ilaprazole Q: What is the CAS Number of Ilaprazole Q: What is the storage condition of Ilaprazole Q: What are the applications of Ilaprazole

laprazole

Ilaprazole

Proton Pump,oral,cancer,ulcers,Inhibitor,TOPK,inhibit,pump,acid,Ilaprazole,gastric

Blue Forest

Oprazole

Ilaprazole, 10 mM in DMSO

172152-36-2