2-Bromo-3,5-difluoropyridine
- Product Name
- 2-Bromo-3,5-difluoropyridine
- CAS No.
- 660425-16-1
- Chemical Name
- 2-Bromo-3,5-difluoropyridine
- Synonyms
- 2-Bromo-3,5-Fluoropyridine;Pyridine, 2-bromo-3,5-difluoro-;2-Bromo-3,5-difluoropyridine ISO 9001：2015 REACH
- CBNumber
- CB51466879
- Molecular Formula
- C5H2BrF2N
- Formula Weight
- 193.98
- MOL File
- 660425-16-1.mol
2-Bromo-3,5-difluoropyridine Property
- Boiling point:
- 36-37°C/0.6mm
- Density
- 1.808±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 44.0±25.9℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- liquid
- pka
- -4.05±0.20(Predicted)
- color
- Clear, almost colourless
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B997145
- Product name
- 2-Bromo-3,5-difluoropyridine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- PC10508
- Product name
- 2-Bromo-3,5-difluoropyridine
- Purity
- 99%
- Packaging
- 1g
- Price
- $32
- Updated
- 2021/12/16
- Product number
- 3H32-B-X2
- Product name
- 2-Bromo-3,5-difluoropyridine
- Purity
- 99%
- Packaging
- 1g
- Price
- $36
- Updated
- 2021/12/16
- Product number
- 008691
- Product name
- 2-Bromo-3,5-difluoropyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $48
- Updated
- 2021/12/16
- Product number
- FB34094
- Product name
- 2-Bromo-3,5-Fluoropyridine
- Packaging
- 1g
- Price
- $85
- Updated
- 2021/12/16
2-Bromo-3,5-difluoropyridine Chemical Properties,Usage,Production
Synthesis
851179-06-1
660425-16-1
A brown suspension was formed from 3,5-difluoro-2-hydrazinylpyridine (Intermediate 18, 16.0 g, 110.26 mmol), which was dissolved in a 500 mL round-bottomed flask with CHCl3 (158 mL). The reaction system was heated to 40 °C, followed by slow dropwise addition of bromine (14.20 mL, 275.65 mmol) over 15 min. After the dropwise addition was completed, the reaction mixture was warmed to 60 °C and refluxed for 1 hour. Upon completion of the reaction, it was cooled to room temperature and the flask was placed in an ice bath to stand. NaHCO3 solution was added slowly to quench the reaction. The reaction mixture was partitioned and extracted with DCM (2 x 80 mL), and the organic phase was dried and concentrated with Na2SO4 to give the crude product. The crude product was purified by silica gel column chromatography using EtOAc/hexane (0-20%) gradient elution. The target fraction was collected and concentrated to afford 2-bromo-3,5-difluoropyridine (12.0 g, 56% yield). The product was confirmed by 1H NMR (δ 8.18 (td, 1H), 8.46 (d, 1H)).
References
[1] Patent: WO2008/132502, 2008, A1. Location in patent: Page/Page column 87
2-Bromo-3,5-difluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-3,5-difluoropyridine manufacturers
- Product
- 2-BROMO-3,5-DIFLUOROPYRIDINE 660425-16-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-19
- Product
- 2-Bromo-3,5-difluoropyridine 660425-16-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-12-20