2-Chloro-5-iodo-3-nitropyridine
- Product Name
- 2-Chloro-5-iodo-3-nitropyridine
- CAS No.
- 426463-05-0
- Chemical Name
- 2-Chloro-5-iodo-3-nitropyridine
- Synonyms
- 2-Chloro-5-iodo-3-nitropy...;2-Chloro-3-nitro-5-iodopyridine;Pyridine, 2-chloro-5-iodo-3-nitro-;2-Chloro-5-iodo-3-nitropyridine ISO 9001：2015 REACH
- CBNumber
- CB51471125
- Molecular Formula
- C5H2ClIN2O2
- Formula Weight
- 284.44
- MOL File
- 426463-05-0.mol
2-Chloro-5-iodo-3-nitropyridine Property
- Melting point:
- 77-81 °C
- Boiling point:
- 334.0±37.0 °C(Predicted)
- Density
- 2.213±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -4.74±0.10(Predicted)
- form
- solid
- Appearance
- Off-white to gray Solid
- InChI
- InChI=1S/C5H2ClIN2O2/c6-5-4(9(10)11)1-3(7)2-8-5/h1-2H
- InChIKey
- PIJMRJPJERUFNI-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(I)C=C1[N+]([O-])=O
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 720054
- Product name
- 2-Chloro-5-iodo-3-nitropyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $37
- Updated
- 2023/06/20
- Product number
- J96590
- Product name
- 2-Chloro-5-iodo-3-nitropyridine
- Packaging
- 250mg
- Price
- $10
- Updated
- 2021/12/16
- Product number
- J96590
- Product name
- 2-Chloro-5-iodo-3-nitropyridine
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
- Product number
- FC55538
- Product name
- 2-Chloro-5-iodo-3-nitropyridine
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 4H54-M-01
- Product name
- 2-Chloro-5-iodo-3-nitropyridine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
2-Chloro-5-iodo-3-nitropyridine Chemical Properties,Usage,Production
Uses
2-Chloro-5-iodo-3-nitropyridine is used in preparation of nitrogen heterocycles as colony stimulating factor-1 receptor (CSF-1R) inhibitors.
Synthesis
25391-57-5
426463-05-0
b) General procedure for the synthesis of 2-chloro-5-iodo-3-nitropyridine from 2-amino-5-iodo-3-nitropyridine: 5-iodo-3-nitropyridin-2-amine (1.3 g, 4.9 mmol) was dissolved in concentrated hydrochloric acid at 0 °C, followed by slow addition of sodium nitrite (6.73 g, 97.13 mmol). Next, a solution of 20 molar equivalents of copper (I) bromide was added dropwise, followed by copper (I) chloride (0.5 g, 4.9 mmol, 1 equiv). The reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, the mixture was poured into a mixture of ammonium hydroxide and water (1:1, v/v) and extracted with ethyl acetate (3 x 150 mL). The organic phases were combined and washed sequentially with water, aqueous sodium thiosulfate and saturated saline, and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to afford the target product 2-chloro-5-iodo-3-nitropyridine in 43% (0.6 g) yield.
References
[1] Patent: WO2013/53983, 2013, A1. Location in patent: Page/Page column 37
[2] Patent: US2015/11548, 2015, A1. Location in patent: Paragraph 0153
[3] Journal of Medicinal Chemistry, 2002, vol. 45, # 21, p. 4755 - 4761
[4] Patent: US6538010, 2003, B1
2-Chloro-5-iodo-3-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-5-iodo-3-nitropyridine manufacturers
- Product
- 2-Chloro-5-iodo-3-nitropyridine 426463-05-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-07-05
- Product
- 2-Chloro-5-iodo-3-nitropyridine 426463-05-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-23
- Product
- 2-Chloro-5-iodo-3-nitropyridine 426463-05-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09