N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDE

Product Name: N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDE
CAS No.: 156886-85-0
Chemical Name: N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDE
Synonyms: Diethylnorspermine HCl;DENSPM tetrahydrochloride;N1,N11-Diethylnorspermine (hydrochloride);N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDE
CBNumber: CB51478063
Molecular Formula: C13H36Cl4N4
Formula Weight: 390.26374
MOL File: 156886-85-0.mol

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N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDE Property

storage temp.: -10 to -25°C
solubility: PBS (pH 7.2): Soluble: =10 mg/ml
form: Solid
color: White to off-white
Water Solubility: Soluble to 100 mM in water

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3711
Product name: DENSPM tetrahydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $126.35
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3711
Product name: DENSPM tetrahydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $534
Updated: 2025/07/31

TRC

Product number: D367013
Product name: N1,N11-DiethylnorspermineTetrahydrochloride
Packaging: 5mg
Price: $305
Updated: 2021/12/16

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N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

N1,N11-Diethylnorspermine Tetrahydrochloride is a polyamine analog binding to human serum albumin induce conformational transition and secondary structure change, a partial protein unfolding.

Biological Activity

DENSPM HCl is a nontoxic polyamine analog th at enhances polyamine catabolism and production of hazardous hydrogen peroxide and N-acetyl-3-aminopropanal by inducing spermidine/spermine-N1-acetyl transferase (SSAT) expression. DENSPM HCl improves stem cell maintenance through reduced translation, exhibits slower proliferation rates in cancer cells, and induces autophagy. It shows greater antitumor activity and less associated toxicity in a human melanoma xenograft model.

in vivo

N1,N11-Diethylnorspermine (40 mg/kg, three times per day for two cycles of 6 days) tetrahydrochloride clearly prevents tumor growth in mice bearing xenografts of the DU-145 cell line^[1].
N1,N11-Diethylnorspermine (120-360 mg/kg, s.c., 4 days) tetrahydrochloride results in prolonged inhibition of tumor growth and long-term tumor regressions in nude athymic mice with MALME-3M melanoma xenografts^[5].
N1,N11-Diethylnorspermine (12.5-50 mg/kg, i.v., 5 days) tetrahydrochloride is well tolerated and induces no physical signs in CD rats^[6].

IC 50

Caspase 3

storage

Store at RT

References

[1] R G SCHIPPER. Antitumor activity of the polyamine analog N(1), N(11)-diethylnorspermine against human prostate carcinoma cells.[J]. Prostate, 2000, 44 4: 313-321. DOI: 10.1002/1097-0045(20000901)44:4<313::aid-pros8>3.0.co;2-d
[2] R. JIANG. Activation of polyamine catabolism by N1,N11-diethylnorspermine leads to cell death in glioblastoma.[J]. International journal of oncology, 2007, 31 2 1: 431-440. DOI: 10.3892/ijo.31.2.431

N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDE Suppliers

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156886-85-0, N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDERelated Search:

N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDE

Diethylnorspermine HCl

DENSPM tetrahydrochloride

N1,N11-Diethylnorspermine (hydrochloride)

156886-85-0