(3-METHYLISOXAZOL-5-YL)METHANOL

Uses

Product Name: (3-METHYLISOXAZOL-5-YL)METHANOL
CAS No.: 14716-89-3
Chemical Name: (3-METHYLISOXAZOL-5-YL)METHANOL
Synonyms: (3-METHYLISOXAZOL-5-YL)METHANO;5-Isoxazolemethanol, 3-methyl-;(3-METHYLISOXAZOL-5-YL)METHANOL;(3-Methyl-5-isoxazolyl)methanol;3-Methyl-5-isoxazoleMethanol, 97%;(3-methyl-1,2-oxazol-5-yl)methanol;5-(Hydroxymethyl)-3-methylisoxazole;5-(Hydroxymethyl)-3-methylisoxazole97%;5-(Hydroxymethyl)-3-methylisoxazole 97%;(3-Methylisoxazol-5-yl)methanol - [M89521]
CBNumber: CB51486774
Molecular Formula: C5H7NO2
Formula Weight: 113.11
MOL File: 14716-89-3.mol

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(3-METHYLISOXAZOL-5-YL)METHANOL Property

Melting point:: 130 °C
Boiling point:: 211.82°C (rough estimate)
Density: 1.1521 g/L at 25℃
refractive index: n/D1.4792
Flash point:: >110℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 13.43±0.10(Predicted)
form: liquid
color: Colourless
InChI: 1S/C5H7NO2/c1-4-2-5(3-7)8-6-4/h2,7H,3H2,1H3
InChIKey: OFSDWHRZVRCPBR-UHFFFAOYSA-N
SMILES: CC1=NOC(CO)=C1

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Safety

WGK Germany: 3
HS Code: 2934999090
Storage Class: 10 - Combustible liquids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 746088
Product name: 5-(Hydroxymethyl)-3-methylisoxazole
Purity: 97%
Packaging: 500mg
Price: $123
Updated: 2023/01/07

TRC

Product number: M324563
Product name: (3-methylisoxazol-5-yl)methanol
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: M324563
Product name: (3-methylisoxazol-5-yl)methanol
Packaging: 500mg
Price: $285
Updated: 2021/12/16

Apolloscientific

Product number: OR15967
Product name: 5-(Hydroxymethyl)-3-methylisoxazole
Packaging: 1g
Price: $174
Updated: 2021/12/16

ChemScene

Product number: CS-0047000
Product name: (3-Methylisoxazol-5-yl)methanol
Packaging: 1g
Price: $290
Updated: 2021/12/16

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(3-METHYLISOXAZOL-5-YL)METHANOL Chemical Properties,Usage,Production

Uses

(Trimethylisoxazole-5-yl)methanol is an alcohol derivative that can be used as a pharmaceutical synthesis intermediate.

Synthesis

4857-42-5

14716-89-3

To a solution of tetrahydrofuran (20 mL) containing 3-methylisoxazole-5-carboxylic acid (3 g, 23.6 mmol) was added lithium aluminum hydride (LiAlH4, 1.8 g, 47.37 mmol) in batches at 0 °C and under nitrogen protection. The reaction mixture was stirred at room temperature for 2 hours before water (2 mL) was slowly added to quench the reaction. Subsequently, the mixture was dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with the eluent being a petroleum ether solution of 10%-30% ethyl acetate, resulting in 3-methylisoxazole-5-methanol as a colorless oil (1.5 g, 56% yield). Mass spectrum (ES, m/z) [M+H]+ 114.1; 1H NMR (300 MHz, CDCl3) δ 6.09 (s, 1H), 4.74 (s, 2H), 2.30 (s, 3H), 2.10 (brs, 1H).

References

[1] Patent: WO2014/66795, 2014, A1. Location in patent: Paragraph 0175
[2] Patent: WO2016/97870, 2016, A1
[3] ChemMedChem, 2017, vol. 12, # 1, p. 50 - 65

(3-METHYLISOXAZOL-5-YL)METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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(3-METHYLISOXAZOL-5-YL)METHANOL Suppliers

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14716-89-3, (3-METHYLISOXAZOL-5-YL)METHANOLRelated Search:

3-METHYLISOXAZOLE-5-CARBOXYLIC ACID 3-PHENYL-ISOXAZOLE-5-CARBOXYLIC ACID METHYL ESTER 2-METHOXYPHENYL (3-PHENYL-5-ISOXAZOLYL)METHYL ETHER (3-PHENYL-5-ISOXAZOLYL)METHYL 3-(TRIFLUOROMETHYL)PHENYL ETHER 3-(4-CHLOROPHENYL)-5-[(3,5-DICHLOROPHENOXY)METHYL]ISOXAZOLE 3-(2-CHLOROPHENYL)-5-[(2,4,5-TRICHLOROPHENOXY)METHYL]ISOXAZOLE 3-(4-CHLOROPHENYL)-5-[(4-METHOXYPHENOXY)METHYL]ISOXAZOLE 5-(PHENOXYMETHYL)-3-PHENYLISOXAZOLE 3,4-DICHLOROPHENYL (3-PHENYL-5-ISOXAZOLYL)METHYL ETHER 3-(4-METHOXYPHENYL)-5-[(2,4,5-TRICHLOROPHENOXY)METHYL]ISOXAZOLE 2,4-DICHLOROPHENYL (3-PHENYL-5-ISOXAZOLYL)METHYL ETHER 4-CHLORO-2-METHYLPHENYL (3-PHENYL-5-ISOXAZOLYL)METHYL ETHER BUTTPARK 153\57-22 2,3-DIMETHYLPHENYL (3-PHENYL-5-ISOXAZOLYL)METHYL ETHER 4-FLUOROPHENYL (3-PHENYL-5-ISOXAZOLYL)METHYL ETHER 1-(3-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-5-ISOXAZOLYL)-1-ETHANOL 3-(4-CHLOROPHENYL)-5-[(2,3-DIMETHYLPHENOXY)METHYL]ISOXAZOLE 3-(4-CHLOROPHENYL)-5-(PHENOXYMETHYL)ISOXAZOLE

5-(Hydroxymethyl)-3-methylisoxazole 97%

5-(Hydroxymethyl)-3-methylisoxazole

(3-methylisoxazol-5-yl)methanol(SALTDATA: FREE)

(3-METHYLISOXAZOL-5-YL)METHANOL

(3-Methylisoxazol-5-yl)methanol, (3-Methyl-1,2-oxazol-5-yl)methanol

5-(Hydroxymethyl)-3-methylisoxazole97%

(3-METHYLISOXAZOL-5-YL)METHANO

3-Methyl-5-isoxazoleMethanol, 97%

(3-methyl-1,2-oxazol-5-yl)methanol

5-Isoxazolemethanol, 3-methyl-

(3-Methyl-5-isoxazolyl)methanol

5-<WBR>(Hydroxymethyl)<WBR>-<WBR>3-<WBR>methylisoxazole

(3-Methylisoxazol-5-yl)methanol - [M89521]

14716-89-3