2,6-DICHLOROPYRIMIDINE-4-CARBONYL CHLORIDE
- Product Name
- 2,6-DICHLOROPYRIMIDINE-4-CARBONYL CHLORIDE
- CAS No.
- 26830-94-4
- Chemical Name
- 2,6-DICHLOROPYRIMIDINE-4-CARBONYL CHLORIDE
- Synonyms
- 2,4-Dichloropyrimidine-6-carbonyl chloride;4-Pyrimidinecarbonyl chloride, 2,6-dichloro-
- CBNumber
- CB51489982
- Molecular Formula
- C5HCl3N2O
- Formula Weight
- 211.43
- MOL File
- 26830-94-4.mol
2,6-DICHLOROPYRIMIDINE-4-CARBONYL CHLORIDE Property
- Density
- 1.675
- refractive index
- 1.588
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H314Causes severe skin burns and eye damage
H332Harmful if inhaled
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D437148
- Product name
- 2,6-Dichloropyrimidine-4-carbonylchloride
- Packaging
- 250mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 067073
- Product name
- 2,6-Dichloropyrimidine-4-carbonyl chloride
- Purity
- 95%
- Packaging
- 1g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 067073
- Product name
- 2,6-Dichloropyrimidine-4-carbonyl chloride
- Purity
- 95%
- Packaging
- 5g
- Price
- $585
- Updated
- 2021/12/16
- Product number
- OR480251
- Product name
- 2,6-Dichloropyrimidine-4-carbonylchloride
- Purity
- 95%
- Packaging
- 5g
- Price
- $696
- Updated
- 2021/12/16
- Product number
- HCH0055197
- Product name
- 2,6-DICHLOROPYRIMIDINE-4-CARBONYL CHLORIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $765.23
- Updated
- 2021/12/16
2,6-DICHLOROPYRIMIDINE-4-CARBONYL CHLORIDE Chemical Properties,Usage,Production
Uses
2,6-Dichloropyrimidine-4-carbonyl Chloride,
Synthesis
65-86-1
26830-94-4
General procedure for the synthesis of 2,6-dichloropyrimidine-4-carbonyl chloride from orotate monohydrate: 1. In a dry reaction flask, whey acid monohydrate (34.828 g, 200.0 mmol), phosphorus trichloride (100 mL, 1092 mmol) and N,N-dimethylformamide (20 drops) were added. 2. The reaction mixture was heated to 110 °C and the reaction was stirred at this temperature overnight. 3. After completion of the reaction, the mixture was cooled to room temperature. 4. Hexane (500 mL) was added to the cooled dark reaction mixture with vigorous stirring. 5. Separate the hexane layer and wash rapidly with deionized water (100 mL x 1) and saturated saline (100 mL x 1) in that order. 6. Dry the organic phase with anhydrous magnesium sulfate and filter to remove the desiccant. 7. The solvent was carefully evaporated under reduced pressure to afford 2,6-dichloropyrimidine-4-carbonyl chloride as a light yellow liquid (26.13 g, 123.6 mmol, 62% yield). Product characterization: 1H NMR (400 MHz, CDCl3) δ 7.93 (s, 1H).
References
[1] Patent: WO2013/30665, 2013, A1. Location in patent: Page/Page column 104; 105
[2] Patent: WO2013/72758, 2013, A1. Location in patent: Page/Page column 93
[3] Patent: WO2014/135955, 2014, A1. Location in patent: Paragraph 0311
[4] Patent: WO2015/31036, 2015, A1. Location in patent: Page/Page column 72; 73
[5] Patent: US2015/175569, 2015, A1. Location in patent: Paragraph 0321
2,6-DICHLOROPYRIMIDINE-4-CARBONYL CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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