5'-TRIFLUOROMETHYL-3,4,5,6-TETRAHYDRO-2H-[1,2']BIPYRIDINYL-4-CARBOXYLIC ACID
- Product Name
- 5'-TRIFLUOROMETHYL-3,4,5,6-TETRAHYDRO-2H-[1,2']BIPYRIDINYL-4-CARBOXYLIC ACID
- CAS No.
- 406476-31-1
- Chemical Name
- 5'-TRIFLUOROMETHYL-3,4,5,6-TETRAHYDRO-2H-[1,2']BIPYRIDINYL-4-CARBOXYLIC ACID
- Synonyms
- AKOS B034494;pyridin-2-yl);AKOS BBS-00001580;BUTTPARK 30\03-94;TIMTEC-BB SBB010208;1-(5-(Trifluoromethyl);1-[5-(Trifluoromethyl)pyridin-2-yl]piperidine-4-;1-[5-(TRIFLUOROMETHYL)PYRID-2-YL]PIPERIDINE-4-CARBOXYLIC ACID;1-[5-(TRIFLUOROMETHYL)-2-PYRIDYL]PIPERIDINE-4-CARBOXYLIC ACID;1-[5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]PIPERIDINE-4-CARBOXYLIC ACID
- CBNumber
- CB5149438
- Molecular Formula
- C12H13F3N2O2
- Formula Weight
- 274.24
- MOL File
- 406476-31-1.mol
5'-TRIFLUOROMETHYL-3,4,5,6-TETRAHYDRO-2H-[1,2']BIPYRIDINYL-4-CARBOXYLIC ACID Property
- Melting point:
- 162 °C
- Boiling point:
- 420.1±45.0 °C(Predicted)
- Density
- 1.366±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 4.23±0.20(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 406476-31-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PC5614
- Product name
- 1-[5-(Trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylicacid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $12
- Updated
- 2021/12/16
- Product number
- 4H21-3-26
- Product name
- 1-[5-(Trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $20
- Updated
- 2021/12/16
- Product number
- PC5614
- Product name
- 1-[5-(Trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $35
- Updated
- 2021/12/16
- Product number
- 4H21-3-26
- Product name
- 1-[5-(Trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $56
- Updated
- 2021/12/16
- Product number
- 019653
- Product name
- 5'-Trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-carboxylic acid
- Packaging
- 500mg
- Price
- $182
- Updated
- 2021/12/16
5'-TRIFLUOROMETHYL-3,4,5,6-TETRAHYDRO-2H-[1,2']BIPYRIDINYL-4-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
420844-59-3
406476-31-1
The general procedure for the synthesis of 1-[5-(trifluoromethyl)-2-pyridinyl]piperidine-4-carboxylic acid from ethyl 1-(5-(trifluoromethyl)pyridin-2-yl)piperidine-4-carboxylate was as follows: ethyl 1-[5-(trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylate, in crude form, was dissolved in a solvent mixture of 15 mL methanol and 2.5 mL water. 535 mg (9.54 mmol) of potassium hydroxide was added and the reaction mixture was stirred at 40 °C for 30 min. Upon completion of the reaction, the solvent was removed by evaporation and the residue was dissolved in water and the pH was adjusted to 3 with 2 N hydrochloric acid solution. the precipitated solid was collected by filtration and dried under vacuum to afford 471 mg (54% yield) of the target product 1-[5-(trifluoromethyl)-2-pyridyl]piperidine-4-carboxylic acid. The product was characterized by 1H NMR (DMSO-d6): δ 1.42-1.60 (m, 2H), 1.81-1.93 (m, 2H), 2.50-2.62 (m, 1H), 3.00-3.14 (m, 2H), 4.21-4.36 (m, 2H), 6.95 (d, 1H), 7.75 (dd, 1H), 8.38 (d , 1H), 12.25 (s, 1H). The molecular weight was 274.24 and mass spectral analysis showed m/z = 275 (M + H)+.
References
[1] Patent: WO2005/40119, 2005, A1. Location in patent: Page/Page column 43
5'-TRIFLUOROMETHYL-3,4,5,6-TETRAHYDRO-2H-[1,2']BIPYRIDINYL-4-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
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