2-Chloro-4-methoxy-6-methylpyrimidine

Product Name: 2-Chloro-4-methoxy-6-methylpyrimidine
CAS No.: 22536-64-7
Chemical Name: 2-Chloro-4-methoxy-6-methylpyrimidine
Synonyms: 2-Chloro-4-methyl-6-methoxypyrimidine;PyriMidine,2-chloro-4-Methoxy-6-Methyl-;2-Chloro-4-methoxy-6-methylpyrimidine ISO 9001：2015 REACH
CBNumber: CB51501299
Molecular Formula: C6H7ClN2O
Formula Weight: 158.59
MOL File: 22536-64-7.mol

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2-Chloro-4-methoxy-6-methylpyrimidine Property

Melting point:: 22-25℃
Boiling point:: 268℃
Density: 1.237
Flash point:: 116℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: C597798
Product name: 2-Chloro-4-methoxy-6-methylpyrimidine
Packaging: 10mg
Price: $40
Updated: 2021/12/16

TRC

Product number: C597798
Product name: 2-Chloro-4-methoxy-6-methylpyrimidine
Packaging: 100mg
Price: $210
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC75178
Product name: 2-Chloro-4-methoxy-6-methylpyrimidine
Packaging: 500mg
Price: $320
Updated: 2021/12/16

AK Scientific

Product number: Z2536
Product name: 2-Chloro-4-methoxy-6-methylpyrimidine
Packaging: 5g
Price: $367
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: NUC0001549
Product name: 2-CHLORO-4-METHOXY-6-METHYLPYRIMIDINE
Purity: 95.00%
Packaging: 250MG
Price: $527
Updated: 2021/12/16

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2-Chloro-4-methoxy-6-methylpyrimidine Chemical Properties,Usage,Production

Synthesis

7749-47-5

22536-64-7

General procedure for the synthesis of 2-chloro-4-methoxy-6-methylpyrimidine from 2-amino-4-methoxy-6-methylpyrimidine: 2-amino-4-methoxy-6-methylpyrimidine (5 g, 35.97 mmol) was dissolved in concentrated hydrochloric acid (50 ml), and aqueous (5 ml) solution of sodium nitrite (2.97 g, 43.16 mmol) was slowly added dropwise. The reaction was maintained at 0°C for 30 min followed by stirring at room temperature for 1 hr. After completion of the reaction, the reaction was quenched with 10N sodium hydroxide solution and the insoluble material was removed by filtration. The filtrate was subjected to liquid-liquid partitioning with ethyl acetate (AcOEt) and saturated saline, and the aqueous layer was then extracted with ethyl acetate. The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give a brown oily crude product. The crude product was purified by fast column chromatography (silica gel: 100-200 mesh, eluent: ethyl acetate-petroleum ether; 10:90→15:85) to obtain 600 mg (8% yield) of white solid, which was the target compound 2-chloro-4-methoxy-6-methylpyrimidine.

References

[1] Patent: WO2017/191599, 2017, A1. Location in patent: Page/Page column 176; 177
[2] Yakugaku Zasshi, 1953, vol. 73, p. 598,600
[3] Chem.Abstr., 1954, p. 9362
[4] Bulletin des Societes Chimiques Belges, 1959, vol. 68, p. 30,55
[5] Patent: US4496392, 1985, A

2-Chloro-4-methoxy-6-methylpyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-4-methoxy-6-methylpyrimidine Suppliers

China 71 India 1 United Kingdom 2 United States 8 Global 82

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View Lastest Price from 2-Chloro-4-methoxy-6-methylpyrimidine manufacturers

Dideu Industries Group Limited

Product: 2-Chloro-4-methoxy-6-methylpyrimidine 22536-64-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-07

22536-64-7, 2-Chloro-4-methoxy-6-methylpyrimidineRelated Search:

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2-Chloro-4-methyl-6-methoxypyrimidine

PyriMidine,2-chloro-4-Methoxy-6-Methyl-

2-Chloro-4-methoxy-6-methylpyrimidine ISO 9001：2015 REACH

22536-64-7

pharmacetical