ChemicalBook > CAS DataBase List > 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE
5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE
Application- Product Name
- 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE
- CAS No.
- 91476-80-1
- Chemical Name
- 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE
- Synonyms
- 5,6,7,8-Tetrahydroimidazo...;5H,6H,7H,8H-iMidazo[1,2-a]pyrazine;5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE;tetrahydro-5,6,7,8 imidazo<1,2-a>pyrazine;Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-;5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine95%;5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine 95%;5,6,7,8-tetrahydroiMidazo[1,2-a]pyrazine hcl;5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride
- CBNumber
- CB51504139
- Molecular Formula
- C6H9N3
- Formula Weight
- 123.16
- MOL File
- 91476-80-1.mol
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5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE Property
- Boiling point:
- 322.8±35.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 7.91±0.20(Predicted)
- form
- solid
- color
- Yellow
- InChI
- InChI=1S/C6H9N3/c1-3-9-4-2-8-6(9)5-7-1/h2,4,7H,1,3,5H2
- InChIKey
- SWBUHQQTIPEPMK-UHFFFAOYSA-N
- SMILES
- C12=NC=CN1CCNC2
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
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N-Bromosuccinimide Price
TRC
- Product number
- H325653
- Product name
- 5H,6H,7H,8H-imidazo[1,2-a]pyrazine
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H32-1-Q3
- Product name
- 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine
- Packaging
- 250mg
- Price
- $138
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 072574
- Product name
- 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine
- Purity
- 97%
- Packaging
- 1g
- Price
- $196
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H32-1-Q3
- Product name
- 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine
- Packaging
- 1g
- Price
- $234
- Updated
- 2021/12/16
Frontier Specialty Chemicals
- Product number
- CAPOD11381
- Product name
- 5,6,7,8-Tetrahydro-imidazo[1,2-a]pyrazine
- Purity
- 92%
- Packaging
- 500mg
- Price
- $325
- Updated
- 2021/12/16
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5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE Chemical Properties,Usage,Production
Application
Imidazolo[1,2-a]pyrazine is a synthetic building block with strong pharmacological activity among nitrogen-containing heterocyclic compounds. 5,6,7,8-Tetrahydroimidazole[1,2-A]pyrazine is a common pharmaceutical and chemical intermediate used in laboratory research and development processes.
Synthesis
274-79-3
91476-80-1
The general procedure for the synthesis of 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine from indolo[1,2-A]pyrazine was as follows: imidazo[1,2-a]pyrazine (7.2 g, 60.44 mmol) was dissolved in 2-methoxyethanol (100 mL). Platinum (IV) oxide (1.2 g, 5.13 mmol) was added to the solution and the mixture was transferred to an autoclave. The reaction mixture was stirred overnight at room temperature and 4 bar hydrogen pressure. Upon completion of the reaction, the hydrogen in the autoclave was replaced with nitrogen and the reaction mixture was filtered through diatomaceous earth to remove the catalyst. The filtrate was concentrated under reduced pressure and co-evaporated with toluene to remove residual solvent. Finally, the target product 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine was purified by column chromatography using a methanol solution of dichloromethane/7N ammonia (95:5, v/v) as eluent to give the target product 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine in a yield of 5.7 g (76% yield).
References
[1] Journal of Chemical Research, Miniprint, 1984, # 2, p. 468 - 480
[2] Patent: US2008/153843, 2008, A1. Location in patent: Page/Page column 67
[3] Patent: CN103864799, 2016, B. Location in patent: Paragraph 0032 - 0335
[4] Patent: EP2604610, 2013, A1. Location in patent: Paragraph 0089; 0091
[5] Patent: US2013/131068, 2013, A1. Location in patent: Paragraph 0117; 0118
5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE manufacturers
Career Henan Chemical Co
- Product
- 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE 91476-80-1
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-03
91476-80-1, 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINERelated Search:
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ETHYL 3-CHLORO-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE,ethyl 3-chloro-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate hydrochloride
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5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid methyl ester,METHYL 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE
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