2-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo-
- Product Name
- 2-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo-
- CAS No.
- 59864-31-2
- Chemical Name
- 2-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo-
- Synonyms
- 1-methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid;2-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo-
- CBNumber
- CB51509240
- Molecular Formula
- C7H7NO3
- Formula Weight
- 153.14
- MOL File
- 59864-31-2.mol
2-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo- Property
- Melting point:
- 247-248 °C
- Boiling point:
- 369.3±35.0 °C(Predicted)
- Density
- 1.381±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.76±0.20(Predicted)
- Appearance
- Off-white to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M401915
- Product name
- 1-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylicacid
- Packaging
- 100mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 119694
- Product name
- 1-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $274
- Updated
- 2021/12/16
- Product number
- CHM0387260
- Product name
- 1-METHYL-6-OXO-1,6-DIHYDROPYRIDINE-2-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.49
- Updated
- 2021/12/16
- Product number
- 119694
- Product name
- 1-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $684
- Updated
- 2021/12/16
- Product number
- Z4924
- Product name
- 1-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylicacid
- Packaging
- 25g
- Price
- $3067
- Updated
- 2021/12/16
2-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo- Chemical Properties,Usage,Production
Synthesis
19621-92-2
74-88-4
59864-31-2
To a 50 mL round bottom flask was added 6-hydroxypyridine-2-carboxylic acid (500 mg, 3.59 mmol) suspended in a solvent mixture of methanol (5 mL) and water (0.8 mL). Subsequently, potassium hydroxide (400 mg, 7.13 mmol) was added to the suspension and the resulting mixture was stirred at 100 °C for 15 min. After the reaction solution was cooled to room temperature, iodomethane (2.6 mL, 41.8 mmol) was added and the mixture was continued to be stirred at 100 °C for 1 hour. Upon completion of the reaction, the solution was concentrated to half of the original volume under reduced pressure. To the concentrated reaction solution was added 3N hydrochloric acid and the resulting solid product was collected by filtration. The solid was washed sequentially with water and acetonitrile and then dried under reduced pressure to afford 1,6-dihydro-1-methyl-6-oxo-2-pyridinecarboxylic acid (339 mg, 62% yield) as a white powder.1H NMR (DMSO-d6, 400 MHz): δ 7.45 (dd, 1H, J = 9.2, 6.9 Hz), 6.72 (dd, 1H, J = 6.9, 1.4 Hz), 6.59 (dd, 1H, J = 9.2, 1.4 Hz), 3.51 (s, 3H).
References
[1] Patent: EP3272750, 2018, A1. Location in patent: Paragraph 0149; 0150
2-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo- Preparation Products And Raw materials
Raw materials
Preparation Products
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