1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid
- Product Name
- 1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid
- CAS No.
- 1001413-01-9
- Chemical Name
- 1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid
- Synonyms
- 1-(3,4-Difluorobenzyl);1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic ac;1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid;1-[(3,4-difluorophenyl)methyl]-1,2-dihydro-2-oxo-3-Pyridine carbocylic acid;3-Pyridinecarboxylic acid, 1-[(3,4-difluorophenyl)Methyl]-1,2-dihydro-2-oxo-
- CBNumber
- CB51512299
- Molecular Formula
- C13H9F2NO3
- Formula Weight
- 265.21
- MOL File
- 1001413-01-9.mol
1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid Property
- storage temp.
- 2-8°C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D449028
- Product name
- 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylicAcid
- Packaging
- 500mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- HCH0361823
- Product name
- 1-(3,4-DIFLUOROBENZYL)-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.1
- Updated
- 2021/12/16
- Product number
- 119538
- Product name
- 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $630
- Updated
- 2021/12/16
- Product number
- X8477
- Product name
- 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylicacid
- Packaging
- 250mg
- Price
- $173
- Updated
- 2021/12/16
- Product number
- 119538
- Product name
- 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $252
- Updated
- 2021/12/16
1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid Chemical Properties,Usage,Production
Synthesis
41530-32-9
72235-53-1
1001413-01-9
A.1 Dissolve dimethyl 2-(3-methoxyallylidene)malonate (5.00 g, 25.0 mmol) in 40 mL of 2-butanol and cool to 5 °C. 3,4-Difluorobenzylamine (3.00 mL, 25.1 mmol) was dissolved in 10 mL 2-butanol and slowly added to the above solution. The reaction mixture was stirred at 20 °C for 1 h, followed by dilution with 150 mL of 2-butanol and heated to 100 °C and kept for 48 hours. After the reaction was completed, 50 mL of aqueous 2N sodium hydroxide solution and 50 mL of 2N sodium hydroxide methanol solution were added and stirring was continued at 20 °C for 2 hours. The reaction mixture was acidified with 1N HCl (50 mL) and the organic layer was extracted with dichloromethane (3 x 50 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and the solvent was concentrated in vacuum to give 1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid (6.08 g, 90% yield; MS (M + H)+ = 266; tR = 0.00 min; LCMS method: BAS1).
References
[1] Patent: WO2011/131741, 2011, A1. Location in patent: Page/Page column 54
[2] Patent: WO2011/144622, 2011, A1. Location in patent: Page/Page column 45
[3] Patent: US2012/94976, 2012, A1. Location in patent: Page/Page column 24
1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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