6-bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole

Product Name: 6-bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole
CAS No.: 1038408-36-4
Chemical Name: 6-bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole
Synonyms: Abesili impurity 6;Abemaciclib Impurity 70;Abemaciclib Impurity N5;6-bromo-1-isopropyl-2-methyl-benzimidazole;6-Bromo-2-methyl-1-propan-2-ylbenzimidazole;6-Bromo-1-isopropyl-2-methyl-1H-benzimidazole;6-BroMo-1-isopropyl-2-Methyl-1H-benzoiMidazole;6-bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole;6-Bromo-2-methyl-1-(1-methylethyl)-1H-benzimidazole;1H-BenziMidazole, 6-broMo-2-Methyl-1-(1-Methylethyl)-
CBNumber: CB51512350
Molecular Formula: C11H13BrN2
Formula Weight: 253.14
MOL File: 1038408-36-4.mol

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6-bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole Property

Boiling point:: 353.9±15.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 5.20±0.10(Predicted)
Appearance: Light brown to brown Oil

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0367678
Product name: 6-BROMO-1-ISOPROPYL-2-METHYL-1H-BENZO[D]IMIDAZOLE
Purity: 95.00%
Packaging: 5MG
Price: $496.19
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 35366
Product name: 6-Bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole
Purity: 95+%
Packaging: 1g
Price: $850
Updated: 2021/12/16

AK Scientific

Product number: 0910AA
Product name: 6-Bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole
Packaging: 5g
Price: $1396
Updated: 2021/12/16

Chemenu

Product number: CM130352
Product name: 6-bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole
Purity: 97%
Packaging: 5g
Price: $954
Updated: 2021/12/16

Crysdot

Product number: CD11361561
Product name: 6-Bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole
Purity: 97%
Packaging: 5g
Price: $1010
Updated: 2021/12/16

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6-bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole Chemical Properties,Usage,Production

Uses

6-Bromo-2-methyl-1-(1-methylethyl)-1H-benzimidazole is used in preparation of Amino Pyrimidine compound for inhibiting protein Tyrosine kinase activity.

Synthesis

1038408-35-3

64-19-7

1038408-36-4

Part D: 5-Bromo-N1-isopropyl-1,2-benzenediamine (0.56 g, 2.45 mmol) was dissolved in glacial acetic acid (20 mL), heated to reflux and stirred for 2 hours. The completion of the reaction was confirmed by LC-MS analysis. The reaction mixture was concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography (eluent: 5% methanol/dichloromethane) to afford 6-bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole (Compound 227) as a red oil in a yield of 0.55 g (90%).1H NMR (400 MHz, DMSO-d6) δ 7.82 (d,1H), 7.44 (1H) 7.24 (dd, 1H), 4.75 (m, 1H), 2.54 (s, 3H), 1.51 (d, 6H).

References

[1] Patent: WO2008/82487, 2008, A2. Location in patent: Page/Page column 110

6-bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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6-bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole Suppliers

China 50 India 1 United States 5 Global 56

Nanjing JinruiJiuAn Biotechnology Co., Ltd.

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1038408-36-4, 6-bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazoleRelated Search:

Tiotropium bromide

6-bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole

1H-BenziMidazole, 6-broMo-2-Methyl-1-(1-Methylethyl)-

6-BroMo-1-isopropyl-2-Methyl-1H-benzoiMidazole

6-Bromo-1-isopropyl-2-methyl-1H-benzimidazole

6-Bromo-2-methyl-1-(1-methylethyl)-1H-benzimidazole

6-Bromo-2-methyl-1-propan-2-ylbenzimidazole

6-bromo-1-isopropyl-2-methyl-benzimidazole

Abesili impurity 6

Abemaciclib Impurity N5

6-bromo-1-isopropyl-2-methyl-1H-benzenebenzo[d]imidazole

Abemaciclib Impurity 70

1038408-36-4