5-bromo-2-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline
- Product Name
- 5-bromo-2-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline
- CAS No.
- 104737-00-0
- Chemical Name
- 5-bromo-2-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline
- Synonyms
- 5-bromo-2-methyl-8-nitro-3,4-dihydro-1H-isoquinoline;5-bromo-2-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline;Isoquinoline, 5-bromo-1,2,3,4-tetrahydro-2-methyl-8-nitro-
- CBNumber
- CB51515801
- Molecular Formula
- C10H11BrN2O2
- Formula Weight
- 271.11
- MOL File
- 104737-00-0.mol
5-bromo-2-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline Property
- Melting point:
- 88-89.5 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 345.7±42.0 °C(Predicted)
- Density
- 1.546±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 7.22±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P000180644
- Product name
- 5-Bromo-2-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline
- Purity
- 97%
- Packaging
- 100mg
- Price
- $21
- Updated
- 2021/12/16
- Product number
- P000180644
- Product name
- 5-Bromo-2-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline
- Purity
- 97%
- Packaging
- 250mg
- Price
- $33
- Updated
- 2021/12/16
- Product number
- 1052AA
- Product name
- 5-Bromo-2-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline
- Packaging
- 100mg
- Price
- $88
- Updated
- 2021/12/16
- Product number
- P000180644
- Product name
- 5-Bromo-2-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline
- Purity
- 97%
- Packaging
- 1g
- Price
- $88
- Updated
- 2021/12/16
- Product number
- HCH0359266
- Product name
- 5-BROMO-2-METHYL-8-NITRO-1,2,3,4-TETRAHYDROISOQUINOLINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.71
- Updated
- 2021/12/16
5-bromo-2-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline Chemical Properties,Usage,Production
Synthesis
947499-02-7
104737-00-0
Ni(NO3)2-6H2O (12.6 g, 43.33 mmol) was dissolved in methanol (200 mL) in a 500 mL three-necked round bottom flask. To this solution was added 5-bromo-8-nitro-N-methylisoquinolinium iodide (33.33 g, 84.38 mmol). Subsequently, NaCNBH3 (10.6 g, 168.68 mmol) was added in batches. The reaction mixture was stirred at room temperature for 5 h. The progress of the reaction was monitored by thin layer chromatography (TLC) (unfolding agent ratio EtOAc:PE = 1:5). After completion of the reaction, the reaction solution was concentrated under reduced pressure using a rotary evaporator. The residue was dissolved in 800 mL of water and the pH was adjusted to 8-10 with 5% NaOH solution. after filtration, the aqueous phase was extracted twice with 800 mL of EtOAc, and the organic layers were combined and dried with Na2SO4. Finally, the residue was purified by column chromatography (eluent ratio EtOAc:PE = 1:5) to afford 19.3 g (83% yield) of 5-bromo-2-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline as a yellow solid.
References
[1] Patent: US2008/318941, 2008, A1. Location in patent: Page/Page column 23
[2] Patent: WO2009/23844, 2009, A2. Location in patent: Page/Page column 105-106
[3] Patent: US2008/200471, 2008, A1. Location in patent: Page/Page column 45; 46
[4] Patent: US2010/16297, 2010, A1. Location in patent: Page/Page column 25
[5] Patent: WO2010/21797, 2010, A1. Location in patent: Page/Page column 69
5-bromo-2-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline Preparation Products And Raw materials
Raw materials
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