ethyl 6-bromobenzo[d]isoxazole-3-carboxylate
- Product Name
- ethyl 6-bromobenzo[d]isoxazole-3-carboxylate
- CAS No.
- 651780-27-7
- Chemical Name
- ethyl 6-bromobenzo[d]isoxazole-3-carboxylate
- Synonyms
- Ethyl 6-bromobenzisoxazole-3-carboxylate;ethyl 6-bromobenzo[d]isoxazole-3-carboxylate;6-Bromobenzisoxazole-3-carboxylic acid ethyl ester;6-bromo-1,2-benzoxazole-3-carboxylic acid ethyl ester;6-Bromobenzo[d]isoxazole-3-carboxylic acid ethyl ester;1,2-Benzisoxazole-3-carboxylic acid, 6-bromo-, ethyl ester
- CBNumber
- CB51515861
- Molecular Formula
- C10H8BrNO3
- Formula Weight
- 270.08
- MOL File
- 651780-27-7.mol
ethyl 6-bromobenzo[d]isoxazole-3-carboxylate Property
- Boiling point:
- 361.3±22.0 °C(Predicted)
- Density
- 1.587
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -7.61±0.30(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8177DK
- Product name
- Ethyl6-bromobenzo[d]isoxazole-3-carboxylate
- Packaging
- 1g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- HCH0361605
- Product name
- ETHYL-6-BROMOBENZISOXAZOLE-3-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.64
- Updated
- 2021/12/16
- Product number
- 61-10715
- Product name
- Ethyl6-bromobenzo[d]isoxazole-3-carboxylate
- Purity
- 95-98%
- Packaging
- 1g
- Price
- $585
- Updated
- 2021/12/16
- Product number
- CM160743
- Product name
- ethyl6-bromobenzo[d]isoxazole-3-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $449
- Updated
- 2021/12/16
- Product number
- CD11078878
- Product name
- Ethyl6-bromobenzo[d]isoxazole-3-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $475
- Updated
- 2021/12/16
ethyl 6-bromobenzo[d]isoxazole-3-carboxylate Chemical Properties,Usage,Production
Synthesis
199328-35-3
651780-27-7
Sodium ethanolate solution was prepared by dissolving sodium metal (33.5 g, 1.46 mol) in ethanol (1.0 L) under nitrogen protection. Ethyl 4-bromo-2-nitrophenylacetate (420 g, 1.46 mol) was dissolved in ethanol (3 L) in a 10 L three-necked round-bottomed flask, isoamyl nitrite (225 mL) was added, and the mixture was subsequently heated to 60 °C. A pre-prepared sodium ethanolate solution (prepared from sodium metal 33.5 g, 1.46 mmol dissolved in ethanol 1 L) was added slowly dropwise and after completion of the dropwise addition, the reaction mixture was maintained to continue the reaction at this temperature for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and neutralized with 2N hydrochloric acid. The reaction mixture was extracted with ethyl acetate (4 × 2 L), the organic phases were combined, washed sequentially with water (2 × 1 L) and saturated brine (2 × 1 L) and dried over anhydrous sodium sulfate. Finally, the residue was purified by column chromatography (eluent ratio from 1/1 to 0/1 hexane/ethyl acetate) to afford 110 g of ethyl 6-bromobenzisoxazole-3-carboxylate in 28% yield.
References
[1] Patent: WO2005/63767, 2005, A2. Location in patent: Page/Page column 44
[2] Patent: US2005/250808, 2005, A1. Location in patent: Page/Page column 40
[3] Patent: US2007/78147, 2007, A1. Location in patent: Page/Page column 72
ethyl 6-bromobenzo[d]isoxazole-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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