ChemicalBook > CAS DataBase List > N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE

N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE

Product Name
N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE
CAS No.
169457-73-2
Chemical Name
N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE
Synonyms
1-Boc-4-(2-bromoethyl)piperidine;N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE;4-(2-bromoethyl)piperidine-1-carboxylate;4-(2-Bromoethyl)-1-(tert-butoxycarbonyl)piperidine;4-(2-Bromoethyl)piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-(2-bromoethyl)-, 1,1-dimethylethyl ester
CBNumber
CB51519425
Molecular Formula
C12H22BrNO2
Formula Weight
292.21
MOL File
169457-73-2.mol
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N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE Property

Melting point:
39-42℃
Boiling point:
334.2±15.0 °C(Predicted)
Density 
1.241±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
-1.52±0.40(Predicted)
form 
liquid
color 
Colourless
InChI
InChI=1S/C12H22BrNO2/c1-12(2,3)16-11(15)14-8-5-10(4-7-13)6-9-14/h10H,4-9H2,1-3H3
InChIKey
CLBWAEYOPRGKBT-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(CCBr)CC1
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific
Product number
097379
Product name
tert-Butyl 4-(2-bromoethyl)-piperidine-1-carboxylate
Purity
95+%
Packaging
250mg
Price
$76
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB154454
Product name
tert-Butyl4-(2-bromoethyl)piperidine-1-carboxylate
Packaging
100mg
Price
$80
Updated
2021/12/16
Matrix Scientific
Product number
097379
Product name
tert-Butyl 4-(2-bromoethyl)-piperidine-1-carboxylate
Purity
95+%
Packaging
500mg
Price
$116
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB154454
Product name
tert-Butyl4-(2-bromoethyl)piperidine-1-carboxylate
Packaging
250mg
Price
$150
Updated
2021/12/16
Matrix Scientific
Product number
097379
Product name
tert-Butyl 4-(2-bromoethyl)-piperidine-1-carboxylate
Purity
95+%
Packaging
1g
Price
$179
Updated
2021/12/16
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N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE Chemical Properties,Usage,Production

Synthesis

89151-44-0

169457-73-2

General procedure for the synthesis of N-Boc-4-(2-bromoethyl)piperidine from N-Boc-4-piperidine ethanol: N-Boc-4-(2-hydroxyethyl)piperidine (0.95 g, 4.17 mmol) was dissolved in anhydrous tetrahydrofuran (20 mL), followed by carbon tetrabromide (1.34 g, 4.0 mmol). A solution of triphenylphosphine (1.15 g, 4.38 mmol) in anhydrous tetrahydrofuran (2 mL) was added slowly and dropwise over 2 hours. The reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, ether (50 mL) was added to the mixture, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (eluent ratio 9:1 hexane:ethyl acetate) to afford the target product N-Boc-4-(2-bromoethyl)piperidine (1.05 g, 86% yield) as an oil.

References

[1] RSC Advances, 2016, vol. 6, # 52, p. 46170 - 46185
[2] Patent: US2007/32469, 2007, A1. Location in patent: Page/Page column 46
[3] Patent: US2009/192169, 2009, A1. Location in patent: Page/Page column 60
[4] Patent: US2013/184313, 2013, A1. Location in patent: Paragraph 1666
[5] Patent: WO2008/27521, 2008, A1. Location in patent: Page/Page column 63

N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE manufacturers

Career Henan Chemical Co
Product
N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE 169457-73-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98%-99.9%
Supply Ability
100kg
Release date
2020-01-10

169457-73-2, N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINERelated Search:

tert-butyl 4-(2-bromophenoxy)piperidine-1-carboxylate 4-(2-BROMO-PROPYL)-PIPERIDIN-1-CARBOXYLIC ACID TERT-BUTYL ESTER N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE

  • N-BOC-4-(2-BROMO-ETHYL)-PIPERIDINE
  • 4-(2-Bromoethyl)-1-(tert-butoxycarbonyl)piperidine
  • 4-(2-Bromoethyl)piperidine-1-carboxylic acid tert-butyl ester
  • 1-Boc-4-(2-bromoethyl)piperidine
  • 1-Piperidinecarboxylic acid, 4-(2-bromoethyl)-, 1,1-dimethylethyl ester
  • 4-(2-bromoethyl)piperidine-1-carboxylate
  • 169457-73-2