6-BOC-3,6-DIAZABICYCLO[3.2.0]HEPTANE
- Product Name
- 6-BOC-3,6-DIAZABICYCLO[3.2.0]HEPTANE
- CAS No.
- 122848-57-1
- Chemical Name
- 6-BOC-3,6-DIAZABICYCLO[3.2.0]HEPTANE
- Synonyms
- 6-BOC-3,6-DIAZABICYCLO[3.2.0]HEPTANE;tert-butyl 3,6-diazabicyclo[3.2.0]heptane-6-carboxylate - [D6474];3,6-Diaza-bicyclo[3.2.0]heptane-6-carboxylic acid tert-butyl ester;cis-3,6-Diazabicyclo[3.2.0]heptane-6-carboxylic acid tert-butylester;3,6-Diazabicyclo[3.2.0]heptane-6-carboxylic acid, 1,1-dimethylethyl ester
- CBNumber
- CB51519627
- Molecular Formula
- C10H18N2O2
- Formula Weight
- 198.26
- MOL File
- 122848-57-1.mol
6-BOC-3,6-DIAZABICYCLO[3.2.0]HEPTANE Property
- Boiling point:
- 276.4±13.0 °C(Predicted)
- Density
- 1.104±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 10.65±0.20(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H290May be corrosive to metals
H301Toxic if swalloed
H314Causes severe skin burns and eye damage
H335May cause respiratory irritation
H361Suspected of damaging fertility or the unborn child
H402Harmful to aquatic life
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P234Keep only in original container.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P308+P313IF exposed or concerned: Get medical advice/attention.
P390Absorb spillage to prevent material damage.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P406Store in corrosive resistant/… container with a resistant inner liner.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B789443
- Product name
- tert-Butyl3,6-Diazabicyclo[3.2.0]heptane-6-carboxylate
- Packaging
- 100mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- 7354AJ
- Product name
- tert-Butyl3,6-diazabicyclo[3.2.0]heptane-6-carboxylate
- Packaging
- 1g
- Price
- $667
- Updated
- 2021/12/16
- Product number
- 122410
- Product name
- cis-3,6-Diazabicyclo[3.2.0]heptane-6-carboxylicacidtert-butylester
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $1304
- Updated
- 2021/12/16
- Product number
- 4H56-1-689
- Product name
- tert-Butyl 3,6-diazabicyclo[3.2.0]heptane-6-carboxylate
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $1690
- Updated
- 2021/12/16
- Product number
- D6474
- Product name
- cis-3,6-Diazabicyclo[3.2.0]heptane-6-carboxylicacidtert-butylester
- Purity
- 97.0%
- Packaging
- 10g
- Price
- $3670
- Updated
- 2021/12/16
6-BOC-3,6-DIAZABICYCLO[3.2.0]HEPTANE Chemical Properties,Usage,Production
Synthesis
370880-79-8
122848-57-1
3-Benzyl-6-tert-butyl-3,6-diazabicyclo[3.2.0]heptane-3,6-dicarboxylate (2.61 mmol) was used as a raw material and dissolved in methanol (0.1 M) in a Parr vial. Palladium/carbon catalyst (Johnson Mathey, 5% wt, 61.1% H2O, 60 mg) was added. The mixture was placed on a Parr shaker and the air was removed by vacuum. The system was purged repeatedly with nitrogen followed by shaking at 15 PSI for about 1.5 hr. The progress of the reaction was monitored by TLC to confirm complete consumption of raw materials. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad. The filtrate was concentrated to afford a viscous clear residue, tert-butyl 3,6-diazabicyclo[3.2.0]heptane-6-carboxylate, in 66.1% yield. The product was sufficiently pure to be used in subsequent reactions without further purification. Mass spectrometry (ESI) calculated value: C10H18N2O2, 198.26; measured value: m/z 199.2 [M + H]+. 1H NMR (400 MHz, CDCl3) δ 4.73-4.50 (m, 1H), 3.98 (t, J = 8.3 Hz, 1H), 3.46-3.15 (m, 2H), 3.09-2.99 (m , 1H), 2.93-2.82 (m, 1H), 2.73-2.62 (m, 1H), 2.53-2.42 (m, 1H), 2.31 (s, 1H), 1.43 (s, 9H).
References
[1] Patent: WO2011/50200, 2011, A1. Location in patent: Page/Page column 60-61
[2] Patent: WO2011/50202, 2011, A1. Location in patent: Page/Page column 50
6-BOC-3,6-DIAZABICYCLO[3.2.0]HEPTANE Preparation Products And Raw materials
Raw materials
Preparation Products
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