pyridine-3-sulfonyl chloride

Product Name: pyridine-3-sulfonyl chloride
CAS No.: 16133-25-8
Chemical Name: pyridine-3-sulfonyl chloride
Synonyms: 3-Pyridine sulphonyl chloride;m-Pyridinesulfonyl chloride;3-PYRIDINESULFONYL CHLORIDE HYDROCHLORIDE;PYRIDINE-3-SULPHONYL CHLORIDE HYDROCHLORIDE;Vonoprazan-8;Vonoprazan-029;TAK438 Impurity 68;Vonolazan impurity 8;Vonoprazan Impurity 50;Vonoprazan intermediate
CBNumber: CB5153121
Molecular Formula: C5H4ClNO2S
Formula Weight: 177.61
MOL File: 16133-25-8.mol

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pyridine-3-sulfonyl chloride Property

Melting point:: 144 °C
Boiling point:: 284℃
Density: 1.488
Flash point:: 126℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: liquid
pka: -1.77±0.11(Predicted)
color: Colourless to light yellow
Stability:: Moisture Sensitive
InChI: InChI=1S/C5H4ClNO2S/c6-10(8,9)5-2-1-3-7-4-5/h1-4H
InChIKey: CDRNYKLYADJTMN-UHFFFAOYSA-N
SMILES: C1=NC=CC=C1S(Cl)(=O)=O
LogP: 1.75
CAS DataBase Reference: 16133-25-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C
Risk Statements: 34-43
Safety Statements: 26-36/37/39-45
RIDADR: 3261
WGK Germany: 3
HazardClass: IRRITANT
PackingGroup: Ⅲ
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS013908
Product name: 3-pyridinesulfonyl chloride hydrochloride
Purity: Aldrich
Packaging: 250mg
Price: $124
Updated: 2024/03/01

Sigma-Aldrich

Product number: 749273
Product name: Pyridine-3-sulfonyl chloride
Purity: 95%
Packaging: 1G
Price: $48.4
Updated: 2023/06/20

TRC

Product number: P991565
Product name: 3-pyridinesulfonylChloride
Packaging: 5g
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR951579
Product name: Pyridine-3-sulfonylchloride
Purity: 98%
Packaging: 25g
Price: $88
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0146974
Product name: 3-PYRIDINE SULFONYL CHLORIDE
Purity: 95.00%
Packaging: 1G
Price: $721.57
Updated: 2021/12/16

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pyridine-3-sulfonyl chloride Chemical Properties,Usage,Production

Uses

3-pyridinesulfonyl Chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.

Application

Pyridine-3-sulfonyl chloride is an essential medical intermediate and is widely applied to the synthesis of medicines, wherein the pyridine-3-sulfonyl chloride is mainly used for preparing TAK-438 (vonoprazan fumarate), which is a novel orally active potassium-competitive acid blocker, developed as an antisecretory drug.

Toxicology

Pyridine-3-sulfonyl chloride causes burns of eyes, skin and mucous membranes. Contact with water liberates toxic gas.

Synthesis

Add thionyl chloride to the water, cool to about 0-5°C, and add cuprous chloride. Fluoboric acid diazonium salt was added to the solution and reacted at 0-5°C overnight. The reaction solution was extracted with dichloromethane, combining the organic layers. The organic layer was washed once with saturated aqueous sodium bicarbonate solution, once with water, and finally once with saturated brine. The product was dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated to remove methylene chloride to obtain the product pyridine-3-sulfonyl chloride with a yield of 90.7%.

pyridine-3-sulfonyl chloride Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide 3-Pyridinesulfonic acid Dichloromethane Thionyl chloride

Preparation Products

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pyridine-3-sulfonyl chloride Suppliers

Belgium 1 China 462 France 1 Germany 2 India 17 Japan 1 United Kingdom 4 United States 16 Global 504

Pure Chemistry Scientific Inc.

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Protheragen-ING

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View Lastest Price from pyridine-3-sulfonyl chloride manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: pyridine-3-sulfonyl chloride 16133-25-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2024-11-14

Hebei Dangtong Import and export Co LTD

Product: pyridine-3-sulfonyl chloride 16133-25-8
Price: US $100.00-60.00/kg
Min. Order: 100kg
Purity: 99.99%
Supply Ability: 100Tons
Release date: 2023-03-17

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 3-Pyridinesulfonyl chloride 16133-25-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100kg
Release date: 2022-02-17

16133-25-8, pyridine-3-sulfonyl chloride Related Search:

PYRIDINE-4-SULFONYL CHLORIDE 1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-, ethyl ester 1H-Pyrrole-3-methanamine, 1-[(1,4-dihydro-3-pyridinyl)sulfonyl]-5-(2-fluorophenyl)-N-methyl- 1H-Pyrrole-3-methanamine, 1-[(1,6-dihydro-3-pyridinyl)sulfonyl]-5-(2-fluorophenyl)-N-methyl- 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde 1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine 5-(4-fluorophenyl)-1H-pyrrole-3-carbonitrile PYRIDINE-2-SULFONIC ACID 1-methylpyridin-1-ium-4-sulfonate (5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl) methanol RARECHEM AL BY 0489 N-NITROSO-DI-ISO-PROPYLAMINE 1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)- Vonoprazan Impurity 24 3-CHLOROPYRIDINE N-OXIDE 2-Bromopropane 3-N,N-dimethylsulfamoylpyridine Malononitrile

3-CHLOROSULFONYL-PYRIDINIUM, CHLORIDE

3-PYRIDINESULFONYL CHLORIDE, HCL

3-PYRIDINESULFONYL CHLORIDE HYDROCHLORIDE

PYRIDINE-3-SULPHONYL CHLORIDE HYDROCHLORIDE

3-Pyridine sulphonyl chloride

m-Pyridinesulfonyl chloride

Piperidine-3-sulfonylchloride

Vonoprazan intermediate

pyridine-3-sulfonyl chloride(SALTDATA: 0.8HCl 0.3H2O)

Vonoprazan-8

Vonoprazan-029

Vonoprazan Impurity 50

PYRIDINE-3-SULFONYL CHLORIDE HYDROCHLO

Vonoprazan Fumarate impurity P

TAK438 Impurity 68

3-CHLOROSULFONYL-PYRIDINIUM

Pyridine-3-Sulphonyl Chloride

Pyridine 3 Sulfonic Acid Chloride

PYRIDINE-3-SULFONYL CHLORIDE HYDROCHLORIDE ISO 9001：2015 REACH

Vonoprazan fumarate intermediates

chloro-3-pyridylsulfone

PYRIDINE-3-SULFONYL CHLORIDE

3-Pyridinesulfonyl chloride (6CI, 8CI, 9CI, ACI)

yridine-3-sulfonyl chloride

3-pyridinesulfonyl chloridde

Vonolazan impurity 8

Pyridine-3-sulfony chloride

5- (2-Fluorophenyl) -1H-pyrrole-3-carboxamide-3-pyridine-3-sulfonyl chloride

16133-25-8

161-25-8

16133-25-5

16133-25-8