2-bromo-4-chloro-1-(difluoromethoxy)benzene
- Product Name
- 2-bromo-4-chloro-1-(difluoromethoxy)benzene
- CAS No.
- 1214348-81-8
- Chemical Name
- 2-bromo-4-chloro-1-(difluoromethoxy)benzene
- Synonyms
- 2-bromo-4-chloro-1-(difluoromethoxy)benzene;Benzene, 2-bromo-4-chloro-1-(difluoromethoxy)-
- CBNumber
- CB51557706
- Molecular Formula
- C7H4BrClF2O
- Formula Weight
- 257.46
- MOL File
- 1214348-81-8.mol
2-bromo-4-chloro-1-(difluoromethoxy)benzene Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B683953
- Product name
- 2-Bromo-4-chloro-1-(difluoromethoxy)benzene
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B683953
- Product name
- 2-Bromo-4-chloro-1-(difluoromethoxy)benzene
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- B683953
- Product name
- 2-Bromo-4-chloro-1-(difluoromethoxy)benzene
- Packaging
- 500mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- B683953
- Product name
- 2-Bromo-4-chloro-1-(difluoromethoxy)benzene
- Packaging
- 1g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- Z8318
- Product name
- 2-Bromo-4-chloro-1-(difluoromethoxy)benzene
- Packaging
- 1g
- Price
- $218
- Updated
- 2021/12/16
2-bromo-4-chloro-1-(difluoromethoxy)benzene Chemical Properties,Usage,Production
Synthesis
695-96-5
1895-39-2
1214348-81-8
To a solution of 2-bromo-4-chlorophenol (4.98 g, 24.0 mmol) in N,N-dimethylformamide (DMF, 25 mL) was sequentially added sodium difluorochloroacetate (8.42 g, 55.2 mmol), cesium carbonate (10.97 g, 33.67 mmol) and water (2.5 mL). The reaction mixture was stirred at 100 °C for 16 hours. After completion of the reaction, the mixture was partitioned between ethyl acetate and water, and the organic phase was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel fast column chromatography eluting with 0-20% ethyl acetate/heptane gradient to afford 2-bromo-4-chloro-1-(difluoromethoxy)benzene as a colorless, transparent oil (2.98 g, 48% yield).No molecular ion peak was detected by LC-MS (ESI); 1H NMR (400 MHz, DMSO-d6) δ: 7.90 (d, 1H) , 7.54 (dd, 1H), 7.38 (d, 1H), 7.28 (t, 1H).
References
[1] Patent: US2014/315933, 2014, A1. Location in patent: Paragraph 0556; 0557; 0558
[2] Patent: US2015/336962, 2015, A1. Location in patent: Paragraph 0638
[3] Patent: WO2018/166993, 2018, A2. Location in patent: Page/Page column 92
[4] Patent: WO2011/3065, 2011, A2. Location in patent: Page/Page column 99
2-bromo-4-chloro-1-(difluoromethoxy)benzene Preparation Products And Raw materials
Raw materials
Preparation Products
2-bromo-4-chloro-1-(difluoromethoxy)benzene Suppliers
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- sales@ajchem.in
- Country
- India
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View Lastest Price from 2-bromo-4-chloro-1-(difluoromethoxy)benzene manufacturers
- Product
- 2-bromo-4-chloro-1-(difluoromethoxy)benzene 1214348-81-8
- Price
- US $1.60-9.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-20
- Product
- 2-bromo-4-chloro-1-(difluoromethoxy)benzene 1214348-81-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
- Product
- 2-bromo-4-chloro-1-(difluoromethoxy)benzene 1214348-81-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-01-03