3,4-Dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid methyl ester

Product Name: 3,4-Dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid methyl ester
CAS No.: 758684-29-6
Chemical Name: 3,4-Dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid methyl ester
Synonyms: Methyl 3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylate;Methyl 2-(cyclohex-2-en-1-yl)-2H-oxazine-6-carboxylate;Methyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carboxylate;,4-Dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid Methyl ester;3,4-Dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid methyl ester;2H-1,4-Benzoxazine-6-carboxylic acid, 3,4-dihydro-, methyl ester
CBNumber: CB51558642
Molecular Formula: C10H11NO3
Formula Weight: 193.2
MOL File: 758684-29-6.mol

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3,4-Dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid methyl ester Property

Melting point:: 73-74 °C
Boiling point:: 337.7±41.0 °C(Predicted)
Density: 1.198±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 3.60±0.20(Predicted)
Appearance: White to light brown Solid

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: D451420
Product name: 3,4-Dihydro-2h-benzo[1,4]oxazine-6-carboxylicacidmethylester
Packaging: 25mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR110097
Product name: Methyl3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate
Packaging: 250mg
Price: $61
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD146239
Product name: 3,4-Dihydro-2H-Benzo[1,4]Oxazine-6-Carboxylic Acid Methyl Ester
Packaging: 100mg
Price: $132
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-072
Product name: Methyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carboxylate
Packaging: 1g
Price: $202
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD146239
Product name: 3,4-Dihydro-2H-Benzo[1,4]Oxazine-6-Carboxylic Acid Methyl Ester
Packaging: 250mg
Price: $230
Updated: 2021/12/16

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3,4-Dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid methyl ester Chemical Properties,Usage,Production

Synthesis

106-93-4

536-25-4

758684-29-6

Step 2. Methyl 3-amino-4-hydroxybenzoate (4.2 g, 25.4 mmol) was dissolved in dimethylformamide (85 mL) and K2CO3 (14.2 g, 102.9 mmol, 4 eq.) and 1,2-dibromoethane (19.3 g, 102.9 mmol, 4 eq.) were added sequentially. The reaction mixture was stirred at 70 °C overnight. Upon completion of the reaction, the insoluble solids were removed by filtration. The filtrate was concentrated under reduced pressure to remove the solvent and the residue was purified by fast column chromatography (eluent: heptane/ethyl acetate gradient) to afford methyl 3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylate (3.65 g, light yellow solid). The product was identified by mass spectrometry (ISP): m/e = 235.1 (M + CH3CN+); NMR hydrogen spectrum (300 MHz, CDCl3) δH: 7.36 (1H, dd, J = 8.5, 2.0), 7.30 (1H, d, J = 2.0), 6.78 (1H, d, J = 8.5), 4.30 (2H, m), 3.85 (3H , s), 3.43 (2H, m).

References

[1] Patent: US2007/191603, 2007, A1. Location in patent: Page/Page column 25
[2] Patent: US2009/176775, 2009, A1. Location in patent: Page/Page column 30
[3] Patent: EP2172453, 2010, A1. Location in patent: Page/Page column 15-16

3,4-Dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-Dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid methyl ester Suppliers

China 37 India 1 United Kingdom 2 United States 6 Global 46

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758684-29-6, 3,4-Dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid methyl esterRelated Search:

3,4-Dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid methyl ester METHYL 2-CYANO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-6-CARBOXYLATE METHYL 3,4-DIHYDRO-3-OXO-2H-BENZO[B][1,4]OXAZINE-6-CARBOXYLATE ETHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-6-CARBOXYLATE 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE-6-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE methyl 2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate

3,4-Dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid methyl ester

Methyl 3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylate

Methyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carboxylate

Methyl 2-(cyclohex-2-en-1-yl)-2H-oxazine-6-carboxylate

,4-Dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid Methyl ester

2H-1,4-Benzoxazine-6-carboxylic acid, 3,4-dihydro-, methyl ester

758684-29-6