5-phenylthiazole-2-carboxylic acid
- Product Name
- 5-phenylthiazole-2-carboxylic acid
- CAS No.
- 937369-77-2
- Chemical Name
- 5-phenylthiazole-2-carboxylic acid
- Synonyms
- 5-phenylthiazole-2-carboxylic acid;2-Thiazolecarboxylic acid, 5-phenyl-;5-phenyl-1,3-thiazole-2-carboxylic Acid
- CBNumber
- CB51560078
- Molecular Formula
- C10H7NO2S
- Formula Weight
- 205.23
- MOL File
- 937369-77-2.mol
5-phenylthiazole-2-carboxylic acid Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Off-white to light yellow Solid
N-Bromosuccinimide Price
- Product number
- P322685
- Product name
- 5-phenylthiazole-2-carboxylicAcid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 184632
- Product name
- Sodium 5-phenyl-1,3-thiazole-2-carboxylic acid
- Packaging
- 0.500g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- 184632
- Product name
- Sodium 5-phenyl-1,3-thiazole-2-carboxylic acid
- Packaging
- 1g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- CHM0101530
- Product name
- 5-PHENYLTHIAZOLE-2-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.42
- Updated
- 2021/12/16
- Product number
- Y5667
- Product name
- 5-Phenylthiazole-2-carboxylicacid
- Packaging
- 5g
- Price
- $1469
- Updated
- 2021/12/16
5-phenylthiazole-2-carboxylic acid Chemical Properties,Usage,Production
Synthesis
58333-72-5
937369-77-2
Ethyl 5-phenyl-2-thiazolecarboxylate (4.5 g, 19.3 mmol) was used as a raw material, which was dissolved in methanol (80 mL), followed by the addition of aqueous sodium hydroxide (150 mL, 4 M). The reaction mixture was stirred at room temperature for 2 h. After completion of the reaction, methanol was removed by distillation under reduced pressure. The remaining aqueous phase was acidified to pH=3 with aqueous hydrochloric acid (1 M) and then extracted with ethyl acetate. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was purified by silica gel column chromatography, eluting with appropriate eluents to give the final target compound 5-phenylthiazole-2-carboxylic acid (3.3 g, 82.3% yield). Mass spectrometry analysis (ESI) showed m/z of 206.0 [M+1].
References
[1] Patent: US2018/271846, 2018, A1. Location in patent: Paragraph 0132; 0137; 0138
5-phenylthiazole-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-phenylthiazole-2-carboxylic acid manufacturers
- Product
- 5-phenylthiazole-2-carboxylic acid 937369-77-2
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02