ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

Product Name: ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate
CAS No.: 1489-97-0
Chemical Name: ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate
Synonyms: 1,4-dioxaspiro[4.5]decane-8-carboxylate;129311;dioxaspiro[4.5]decane-8-carboxyL;dioxaspiro[4.5]decane-8-carboxylate;1,4-Dioxa-8-carboethoxyspiro[4.5]decane;Ethyl 1,4-Dioxaspiro[4.5]decan-8-carboxylate;ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate;Ethyl cyclohexanone-4-carboxylate ethylene ketal;Ethyl 4-Oxocyclohexanecarboxylate Ethylene Ketal;1,4-Dioxaspiro[4.5]decane-8-carboxylic Acid Ethyl Ester
CBNumber: CB51560548
Molecular Formula: C11H18O4
Formula Weight: 214.26
MOL File: 1489-97-0.mol

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ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate Property

Boiling point:: 293.0±40.0 °C(Predicted)
Density: 1.12±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Dichloromethane, Ethyl Acetate
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C11H18O4/c1-2-13-10(12)9-3-5-11(6-4-9)14-7-8-15-11/h9H,2-8H2,1H3
InChIKey: UXXWGBLTOSRBAY-UHFFFAOYSA-N
SMILES: O1C2(CCC(C(OCC)=O)CC2)OCC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Medical Isotopes, Inc.

Product number: 64617
Product name: 1,4-Dioxaspiro[4.5]decane-8-carboxylicAcidEthylEster
Packaging: 250mg
Price: $650
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0118302
Product name: ETHYL 1,4-DIOXASPIRO[4.5]DECANE-8-CARBOXYLATE
Purity: 95.00%
Packaging: 250MG
Price: $750.75
Updated: 2021/12/16

AK Scientific

Product number: 4006AJ
Product name: Ethyl1,4-dioxaspiro[4.5]decane-8-carboxylate
Packaging: 100g
Price: $917
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0118302
Product name: ETHYL 1,4-DIOXASPIRO[4.5]DECANE-8-CARBOXYLATE
Purity: 95.00%
Packaging: 2.5G
Price: $2035
Updated: 2021/12/16

Ambeed

Product number: A214539
Product name: Ethyl1,4-dioxaspiro[4.5]decane-8-carboxylate
Purity: 95%
Packaging: 1g
Price: $17
Updated: 2021/12/16

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ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate Chemical Properties,Usage,Production

Uses

ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate can be used in the preparation of arylcyclohexanones analgesics, metalloproteinase inhibitors, benzimidazole derivatives as therapeutic TRPM8 receptor modulators and aposptosis inducing agents.

Synthesis

17159-79-4

107-21-1

1489-97-0

Ethyl 4-oxo-cyclohexanecarboxylate (52.8 g, 0.31 mol), ethylene glycol (67.4 g, 1.08 mol) and p-toluenesulfonic acid (0.7 g) were dissolved in toluene (160 mL) and the reaction mixture was stirred at room temperature. After the reaction was completed, the reaction solution was poured into ether (300 mL), washed sequentially with water, sodium bicarbonate solution and sodium chloride solution, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give a colorless liquid product. The product was directly used in the next reaction without further purification, yield: 66.5 g (100%).1H-NMR (CDCl3) δ: 1.24 (t, 3H), 1.53 (m, 2H), 1.76 (m, 4H), 1.92 (m, 2H), 2.31 (m, 1H), 3.91 (s, 4H), 4.11 (q, 2H).13C- NMR (CDCl3) δ: 14.28 (q), 26.32 (t), 33.76 (t), 41.59 (d), 60.14 (t), 64.21 (t), 107.90 (d), 174.77 (s). Sec-butanediol (1.08 mol) and p-toluenesulfonic acid (0.7 g) were added to a solution of ethyl 4-oxo-cyclohexanecarboxylate (0.31 mol) in toluene (160 mL) and stirred for 20 hr at 25 °C. At the end of the reaction, ethyl acetate (300 mL) was added, and the organic phase was separated, washed sequentially with water, saturated aqueous sodium bicarbonate solution, and sodium chloride solution, dried over anhydrous sodium sulfate, filtered, and the solvent was removed under reduced pressure. The resulting product can be used in the next reaction without further purification.

References

[1] Synthesis, 1998, # 4, p. 436 - 443
[2] Patent: US2008/306084, 2008, A1. Location in patent: Page/Page column 33-34; 44-45
[3] Patent: US2008/312231, 2008, A1. Location in patent: Page/Page column 17
[4] Patent: US2009/48323, 2009, A1. Location in patent: Page/Page column 14; 16
[5] Patent: US2009/111842, 2009, A1. Location in patent: Page/Page column 8

ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate Preparation Products And Raw materials

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View Lastest Price from ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate 1489-97-0
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-24

Henan Aochuang Chemical Co.,Ltd.

Product: ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate 1489-97-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Shanghai Yongzeng Technology Co.,Ltd

Product: ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate 1489-97-0
Price: US $0.00/gm
Min. Order: 100gm
Purity: 96%
Supply Ability: 1kgs
Release date: 2024-09-10

1489-97-0, ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylateRelated Search:

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Ethyl 1,4-Dioxaspiro[4.5]decan-8-carboxylate

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129311

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1489-97-0

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