6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one
Uses- Product Name
- 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one
- CAS No.
- 109229-22-3
- Chemical Name
- 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one
- Synonyms
- 6-benzyl-5;3-d]pyriMidin-4(3H)-one;6-benzyl-3H,4H,5H,6H,7H,8H-pyrido[4,3-d]pyriMidin-4-one;6-benzyl-1H,4H,5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-4-one;6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H);Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyriMidin-4(3H)-one;6-Benzyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyriMidin-4-one;6-Benzyl-5,6,7,8-tetrahydro-3H-pyrido[4,3-d]pyrimidin-4-one;6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one;5,6,7,8-Tetrahydro-6-(benzyl)-pyrido[4,3-d]pyrimidin-4(3H)-one
- CBNumber
- CB51562360
- Molecular Formula
- C14H15N3O
- Formula Weight
- 241.29
- MOL File
- 109229-22-3.mol
6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one Property
- Melting point:
- 165-166.5 °C(Solv: acetone (67-64-1))
- Boiling point:
- 406.5±55.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 6.65±0.20(Predicted)
- Appearance
- Light yellow to yellow Solid
N-Bromosuccinimide Price
- Product number
- B296215
- Product name
- 6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- X8904
- Product name
- 6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one
- Packaging
- 1g
- Price
- $318
- Updated
- 2021/12/16
- Product number
- CHM0391264
- Product name
- 6-BENZYL-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.1
- Updated
- 2021/12/16
- Product number
- X8904
- Product name
- 6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one
- Packaging
- 5g
- Price
- $804
- Updated
- 2021/12/16
- Product number
- 069990
- Product name
- 6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one
- Purity
- >95%
- Packaging
- 1g
- Price
- $870
- Updated
- 2021/12/16
6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one Chemical Properties,Usage,Production
Uses
6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one is used in the discovery/optimization of quinazolinones as new P2X3 receptor antagonists.
Uses
6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one is used in the discovery/optimization of quinazolinones as new P2X3 receptor antagonists.
Synthesis
3473-63-0
1454-53-1
109229-22-3
1. in a 350 mL sealed reactor, ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (50.0 g, 0.168 mol), formamidine acetate (16.2 g, 0.201 mol), a methanolic solution of 4.37 M sodium methanolate (190 mL), and methanol (200 mL) were mixed. 2. the reaction mixture was heated to 85 °C and maintained for 16 hours. 3. Upon completion of the reaction, the mixture was cooled and concentrated under reduced pressure.4. The concentrated residue was dissolved in 1 N NaOH solution (150 mL), which was subsequently poured into ice water.5. The pH of the mixture was adjusted to 7 by slow addition of glacial acetic acid, and a tan solid precipitated.6. The solid was collected by filtration, and washed sequentially with water and cold ethyl ether.7. It was dried under high vacuum to afford 6-benzyl-5,6,7,8-tetrahydropyridine and [4,3-d]pyrimidin-4(3H)-one as a brown solid (26.2 g, 61.4% yield). 8. Mass spectrometry showed [M + H]+ = 242.2. 9. 1H NMR (DMSO-d6) δ: 2.29 (t, J = 5.8 Hz, 2H), 2.61 (t, J = 5.8 Hz, 2H), 3.26 (s, 2H), 3.64 (s, 2H), 3.65 (s, 2H), 3.66 (s, 2H), 3.67 (s, 2H), 3.67 (s, 2H). 3.64 (s, 2H), 7.21-7.36 (m, 6H), 7.96 (s, 1H).
References
[1] Patent: US2006/258689, 2006, A1. Location in patent: Page/Page column 22; 23; 27; 28
[2] Patent: US2008/275037, 2008, A1. Location in patent: Page/Page column 22
[3] Patent: WO2008/123963, 2008, A1. Location in patent: Page/Page column 44
[4] Patent: WO2011/103715, 2011, A1. Location in patent: Page/Page column 38
[5] Patent: WO2011/106276, 2011, A1. Location in patent: Page/Page column 38
6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one Preparation Products And Raw materials
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View Lastest Price from 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one manufacturers
- Product
- 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one 109229-22-3
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12