OMEPRAZOLE

Product Name: OMEPRAZOLE
CAS No.: 119141-89-8
Chemical Name: OMEPRAZOLE
Synonyms: PRILOSEC;LOSEC;5-METHOXY-2[(4-METHOXY-3,5-DIMETHYL-2-PYRIDYL)METHYLSULFINYL]-1H-BENZIMIDAZOLE;ANTRA;MEPRAL;ZOLTUM;MOPRAL;OMEPRAL;H 168/68;GASTROLOC
CBNumber: CB5160491
Molecular Formula: C17H19N3O3S
Formula Weight: 345.42
MOL File: 119141-89-8.mol

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OMEPRAZOLE Property

Melting point:: >47°C (dec.)
Boiling point:: 600.0±60.0 °C(Predicted)
Density: 1.37±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: Sealed in dry,Room Temperature
solubility: H₂O: 0.5 mg/mL
form: solid
pka: 8.78±0.10(Predicted)
color: white
Stability:: Hygroscopic
InChI: InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)/t24-/m1/s1
InChIKey: SUBDBMMJDZJVOS-XMMPIXPASA-N
SMILES: C1([S@@](CC2=NC=C(C)C(OC)=C2C)=O)NC2=CC(OC)=CC=C2N=1

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 2
RTECS: DD9087000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: O634995
Product name: (R)-Omeprazole
Packaging: 10mg
Price: $1060
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0002053
Product name: (R)-OMEPRAZOLE
Purity: 95.00%
Packaging: 100MG
Price: $1758.49
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 12794
Product name: (R)-OmeprazoleSodiumSalt
Purity: 99%
Packaging: 5mg
Price: $2120
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0002053
Product name: (R)-OMEPRAZOLE
Purity: 95.00%
Packaging: 10MG
Price: $697.34
Updated: 2021/12/16

Alichem

Product number: 119141898
Product name: (R)-5-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole
Packaging: 1g
Price: $747.3
Updated: 2021/12/16

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OMEPRAZOLE Chemical Properties,Usage,Production

Uses

R-Form of Omeprazole. Gastric proton-pump inhibitor

Uses

(R)-Omeprazole is the R-enantiomer of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.

Definition

ChEBI: A 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole that has R configuration at the sulfur atom.

Synthesis

73590-85-9

119141-89-8

GENERAL STEPS: Sulfide (5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]thio]benzimidazole, 100 mmol) and titanium-tannic acid catalyst (1.1 mmol) were dissolved in ethyl acetate (EtOAc, 6.0 mL). The reaction mixture was kept at a constant temperature to the indicated temperature (usually 0°C, or in the range of -20 to +20°C for variable temperature experiments). Subsequently, a 30% aqueous hydrogen peroxide solution (0.105 mmol H2O2) was added all at once. The reaction mixture was continuously stirred at 500 rpm at a constant temperature (usually 24 h). For low-temperature experiments, the reaction time was about 30 h at -10 °C, which could be extended to 10 days at -20 °C. To analyze the progress of the reaction, 20 μL of the reaction mixture was taken into a vial and immediately evaporated carefully to dryness (~15-20 s) with a stream of compressed air. The residual solid was dissolved in isopropanol solution (0.20 mL) containing 1% triethylamine (Et3N), and the residual sulfide, (R)- and (S)-sulfoxide, and sulfone contents were analyzed by chiral HPLC.

References

[1] Catalysis Today, 2017, vol. 279, p. 84 - 89
[2] Heterocyclic Communications, 2016, vol. 22, # 1, p. 17 - 19
[3] Patent: US2008/319195, 2008, A1. Location in patent: Page/Page column 5
[4] Patent: US9228216, 2016, B2. Location in patent: Page/Page column 50-52
[5] Journal of Organic Chemistry, 2018, vol. 83, # 14, p. 7453 - 7458

OMEPRAZOLE Preparation Products And Raw materials

Raw materials

Ammonium thiocyanate Erythromycin

Preparation Products

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OMEPRAZOLE Suppliers

Canada 2 China 115 India 4 South Korea 1 United States 6 Global 128

Zhongxin Chenshi (Wuhan) Technology Co., Ltd

Tel: 18942922096
Fax: QQ 2662561040
Email: 2662561040@qq.com
Country: China
ProdList: 1008
Advantage: 58

Hefei fuya biotechnology co. LTD

Tel: 18096409024
Email: sales02@foreversyn.com
Country: China
ProdList: 1961
Advantage: 58

Henan Kangsheng New Materials Co., LTD

Tel: 18971085384
Email: 183320562@qq.com
Country: China
ProdList: 109
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 5158
Advantage: 50

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-83725681-603
Fax: +86 755 28094224
Country: China
ProdList: 4496
Advantage: 50

Cato Research Chemicals Inc.

Tel: 020-81960175
Fax: +1-541-2553641
Email: min.he@cato-chem.com
Country: China
ProdList: 1955
Advantage: 55

Eastbang Pharmaceuticals Technology Co., Ltd.

Tel: +86 (20) 28996708,29078958,28139708,29076128,28133708,28139728,28139738,28133718,021-31663278,021-31663578,021-60538387
Fax: +86 (20) 39218032
Country: China
ProdList: 454
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

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View Lastest Price from OMEPRAZOLE manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Omeprazole Impurity 25 119141-89-8
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-05-15

Career Henan Chemical Co

Product: OMEPRAZOLE 119141-89-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2018-08-08

119141-89-8, OMEPRAZOLERelated Search:

5-METHOXYBENZIMIDAZOLE

ZOLTUM

6-methoxy-2-[(R)-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole

Omeprazole Impurity N

R-Omeparazole

Esomeprazole Sodium Impurity 15

Omeprazole Impurity 33

omeprazole impurity B (r-omeprazole)

Omeprazole impurity 18/(R)-Omeprazole/(R)-5-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole

MEPRAL

LOSEC

H 168/68

GASTROGARD

GASTROLOC

ANTRA

2-[(4-METHOXY-3,5-DIMETHYLPYRID-2-YL)-METHYLSULFO]-5-METHOXYBENZIMIDAZOLE

5-METHOXY-2-[[(4-METHOXY-3,5-DIMETHYL-2-PYRIDINYL)METHYL]SULFINYL]-1H-BENZIMIDAZOLE

5-METHOXY-2[(4-METHOXY-3,5-DIMETHYL-2-PYRIDYL)METHYLSULFINYL]-1H-BENZIMIDAZOLE

Erythromycine Thiocynate

(R)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

6-Methoxy-2-[(R)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole

R-(+)-OMEPRAZOLE

(S)-OMEPRAZOLE

OMEPRAL

PRILOSEC

MOPRAL

(R)-6-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole

Esomeprazole EP Impurity F

1H-BenziMidazole,6-Methoxy-2-[(R)-[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]sulfinyl]-

5-Methoxy-2-[(R)-[(4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl]sulfinyl]-1H-benziMidazole

EsoMeprazole iMpurity F

Omeprazole impurity N (R)-Omeprazole

Omeprazole R-Isomer

(+)-omeprazole

Esomeprazole Impurity 6 Monomer

Esomeprazole magnesium dihydrate EP Impurity F

Omeprazole Impurity N (Esomeprazole-magnesium EP Impueity F)

(R)-5-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole (Esomeprazole Impurity）

Trimethoprim Impurity 17

Esomeprazole magnesium EP Impurity F

119141-89-8

Cell Biology

Cell Signaling and Neuroscience

BioChemical

Voltage-gated Ion Channels

Potassium Channel Modulators

Ion Channels

Monovalent Ion Channels

Chiral Reagents

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals