1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
- Product Name
- 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
- CAS No.
- 306935-41-1
- Chemical Name
- 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
- Synonyms
- IBC 293;IPBT-5CA;BUTTPARK 36\04-50;GPR109 receptor agonist-1;1-ISOPROPYLBENZOTRIAZOLE-5-CARBOXYLIC ACID;1-propan-2-ylbenzotriazole-5-carboxylic acid;1-propan-2-yl-5-benzotriazolecarboxylic acid;1-ISOPROPYL-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID;1-Isopropyl-1,2,3-benzotriazole-5-carboxylic acid;1-(1-METHYLETHYL)-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID
- CBNumber
- CB5160800
- Molecular Formula
- C10H11N3O2
- Formula Weight
- 205.21
- MOL File
- 306935-41-1.mol
1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID Property
- Melting point:
- 229-230°C
- Boiling point:
- 413.9±18.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- Soluble in DMSO (up to 25 mg/ml).
- form
- Light brown solid
- pka
- 3.50±0.30(Predicted)
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- CAS DataBase Reference
- 306935-41-1(CAS DataBase Reference)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- Hazard Note
- Irritant
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 15223
- Product name
- IPBT-5CA
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 15223
- Product name
- IPBT-5CA
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 15223
- Product name
- IPBT-5CA
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 15223
- Product name
- IPBT-5CA
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 2469
- Product name
- IBC293
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $96
- Updated
- 2021/12/16
1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production
Description
IPBT-5CA (306935-41-1) is a highly selective agonist for the human orphan G-protein-coupled receptor GPR109b (EC50 = 400 nM). No activity was reported at the highly homologous high-affinity niacin receptor GPR109a.
Definition
ChEBI: 1-propan-2-yl-5-benzotriazolecarboxylic acid is a member of benzotriazoles.
Biological Activity
Highly selective agonist for GPR109B (HM74), the human orphan G-protein-coupled receptor expressed in adipocytes. Selective for GPR109B over closely related niacin receptor GPR109A (HM74A); EC 50 values are 400 nM and > 1 μ M respectively. In vitro, inhibits isoproterenol-stimulated lipolysis in isolated human adipocytes.
References
1) Semple et al. (2006) 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b; J. Med. Chem., 49 1227
1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID manufacturers
- Product
- 1-Isopropyl-1H-1,2,3-Benzotriazole-5-Carboxylic Acid 306935-41-1
- Price
- US $104.00-597.00/g
- Min. Order
- 1g
- Purity
- 0.98
- Supply Ability
- 25kg
- Release date
- 2023-12-21
- Product
- 1-propan-2-ylbenzotriazole-5-carboxylic acid 306935-41-1
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g;1kg； 25kg
- Release date
- 2020-01-09