MIDECAMYCIN

Product Name: MIDECAMYCIN
CAS No.: 35457-80-8
Chemical Name: MIDECAMYCIN
Synonyms: medemycin;medecamycin;mydecamycin;sf837;Aboren;Myoxam;Midecin;Momicin;Macropen;SF 837A1
CBNumber: CB5175530
Molecular Formula: C41H67NO15
Formula Weight: 813.97
MOL File: 35457-80-8.mol

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MIDECAMYCIN Property

Melting point:: 155℃ -156℃
Boiling point:: 874℃
alpha: D23 -67° (c = 1 in ethanol)
Density: 1.1651 (rough estimate)
refractive index: 1.6220 (estimate)
Flash point:: >110°(230°F)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form: Solid
pka: 6.9 in 50% aq ethanol
color: White to Off-White
Water Solubility: Soluble in methanol or ethanol. Insoluble in water
InChIKey: DMUAPQTXSSNEDD-INMHWYRMNA-N

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Safety

RTECS: OH4730600

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological

Product number: 017648
Product name: Midecamycin
Packaging: 1g
Price: $460
Updated: 2021/12/16

Usbiological

Product number: 257342
Product name: Midecamycin
Packaging: 500mg
Price: $468
Updated: 2021/12/16

TRC

Product number: M343250
Product name: Midecamycin(>85%)
Packaging: 10g
Price: $1190
Updated: 2021/12/16

AK Scientific

Product number: R025
Product name: Mydecamycin
Packaging: 25mg
Price: $104
Updated: 2021/12/16

ChemScene

Product number: CS-5909
Product name: Midecamycin
Purity: >98.0%
Packaging: 100mg
Price: $108
Updated: 2021/12/16

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MIDECAMYCIN Chemical Properties,Usage,Production

Description

Midecamycin, a macrolide antibiotic having a 16-membered lactone ring, was found in the culture broth of Streptomyces mycarofaciens by Meiji Seika Kaisha in 1971. Under specific culture conditions, it is produced by the organism as a single component. Midecamycin shows almost the same antimicrobial spectrum and activity as kitasamycin. Although its serum and urine concentrations are low, it distributes in tissues at high concentration following oral administration.

Chemical Properties

White Solid

Originator

Medemycin,Meiji Seika,Japan,1974

Uses

A broad spectrum antibiotic

Uses

A 16-membered ring macrolide antibiotic used in ophthalmology as well as other medical fields.

Definition

ChEBI: Midecamycin is an organic molecular entity.

Manufacturing Process

The SF-837 strain, namely Streptomyces mycarofaciens identified as ATCC No. 21454 was inoculated to 60 liters of a liquid culture medium containing 2.5% saccharified starch, 4% soluble vegetable protein, 0.3% potassium chloride and 0.3% calcium carbonate at pH 7.0, and then stir-cultured in a jarfermenter at 28°C for 35 hours under aeration. The resulting culture was filtered directly and the filter cake comprising the mycelium cake was washed with dilute hydrochloric acid.
The culture filtrate combined with the washing liquid was obtained at a total volume of 50 liters (potency 150 mcg/ml). The filtrate (pH 8) was then extracted with 25 liters of ethyl acetate and 22 liters of the ethyl acetate phase was concentrated to approximately 3 liters under reduced pressure. The concentrate was diluted with 1.5 liters of water, adjusted to pH 2.0 by addition of 5N hydrochloric acid and then shaken thoroughly. The aqueous phase was separated from the organic phase and this aqueous solution was adjusted to pH 8 by addition of 3N sodium hydroxide and then extracted with 800 rnl of ethyl acetate. The resulting ethyl acetate extract was then shaken similarly together with 500 ml of aqueous hydrochloric acid to transfer the active substances into the latter which was again extracted with 400 ml of ethyl ether at pH 8.The ether extract was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 16.5 g of light yellow colored powder.
12 g of this crude powder were dissolved in 200 ml of ethyl acetate and the solution was passed through a column of 600 ml of pulverized carbon which had been impregnated with ethyl acetate. The development was carried out using ethyl acetate as the solvent and the active fractions of eluate were collected to a total volume of 2,500 ml, which was then evaporated to dryness under reduced pressure to yield 5 g of a white colored powder. This powder was dissolved in 10 ml of benzene and the insoluble matters were filtered out. The filtered solution in benzene was then subjected to chromatographic isolation by passing through a column of 700 ml of silica gel which had been impregnated with benzene. The development of the active substances adsorbed on the silica gel was effected using a solvent system consisting of benzene-acetone (4:1), and the eluate was collected in fractions of each 20 ml. The active fractions No. 90-380 which gave a single spot in alumina thin layer chromatography and which could be recognized as containing the SF- 837 substance purely in view of the Rf-value of the single spot were combined together to a total volume of 4,000 ml, and then concentrated under reduced pressure to yield 1.5 g of white colored powder of a melting point of 122°C to 124°C which was found by analysis to be the pure SF-837 substance free base.

Therapeutic Function

Antibacterial

Pharmaceutical Applications

A naturally occurring metabolite of Streptomyces mycarofaciens, supplied as the native compound and as midecamycin acetate for oral administration.
It is rapidly and extensively metabolized and is said to exhibit less toxicity than earlier macrolides. It is of limited availability.

MIDECAMYCIN Preparation Products And Raw materials

Raw materials

Preparation Products

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MIDECAMYCIN Suppliers

Canada 1 China 130 Germany 1 India 2 Japan 1 Switzerland 1 United Kingdom 5 United States 23 Global 164

MedChemexpress LLC

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View Lastest Price from MIDECAMYCIN manufacturers

.GZ HONESTCHEM CO.,LTD

Product: Midecamycin 35457-80-8
Price: US $1.00/g
Min. Order: 300g
Purity: 99.8%
Supply Ability: 20 TONS
Release date: 2021-07-09

Baoji Guokang Healthchem co.,ltd

Product: MIDECAMYCIN 35457-80-8
Price: US $238.10/g
Min. Order: 100g
Purity: 99%
Supply Ability: 200kg
Release date: 2021-06-10

Career Henan Chemical Co

Product: MIDECAMYCIN 35457-80-8
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

35457-80-8, MIDECAMYCINRelated Search:

Sulbactam Acetaminophen Retinoic acid Ampicillin Telithromycin DIOXOPROMETHAZINE HCL MELEUMYCIN Midecamycin Acetate MIDECAMYCIN ETHYL 3 ACETOXY HEXANOATE Oxytetracycline dihydrate Midecamycin A3 E,E-8,10-DODECADIEN-1-YL ACETATE ISO-PROPYL-UNDECYLENATE Medemycin hydrochloride midecamycin 4''-propionyltransferase ACETYL MIDECAMYCIN midecamycin 4''-acylase

antibioticsf837

sf837

turimycinp(sub3)

LEUCOMYCIN V 3,4B-DIPROPIONATE

Aboren

Leucomycin V, 3,4B-dipropanoate (9CI)

Macropen

Medecamycin A1

Medemycin A1

Midecamycin A1

Midecin

Momicin

Mydecamycin A1

Myoxam

Normicina

NSC 154011

Oxacyclohexadecane, leucomycin V deriv.

Rubimycin

SF 837A1

Turimycin P3

YL 704B1

medecamycin

MIDECAMYCIN

MIDECAMYCINE

midecamycin from streptomyces*mycarofaciens

MIDECAMYCIN FROM STREPTOMYCES &

Leucomycin V 3,4''-dipropionate

Leucomycin V 3,4<sup>B</sup>-dipropionate

Midecamycin, >98%

propanoic acid [(11Z,13E)-6-[[(2S,3R,4R,5S,6R)-4-(dimethylamino)-3-hydroxy-5-[[(2S,4R,5R,6R)-4-hydroxy-4,6-dimethyl-5-(1-oxopropoxy)-2-oxanyl]oxy]-6-methyl-2-oxanyl]oxy]-10-hydroxy-5-methoxy-9,16-dime

antibioticsf837a1

antibioticyl704b1

espinomycina

leucomycinv,3,4(supb)-dipropanoate

medemycin

midecamycina(sub1)

mydecamycin

platenomycinb1

DMUAPQTXSSNEDD-BJXZGPOLSA-N

LeucoMycin V 3,4B-Dipropanoate

MoMicine

MIDECAMYCIN USP/EP/BP

Midecamycin (>85%)

(2S,3S,4R,6S)-6-{[(2R,3S,4R,5R,6S)-4-(dimethylamino)-5-hydroxy-6-{[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-4-(propanoyloxy)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy}-2-methyloxan-3-yl]oxy}-4-hydroxy-2,4-dimethyloxan-3-yl propanoate

(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-(((2S,3R,4R,5S,6R)-4-(Dimethylamino)-3-hydroxy-5-(((2S,4R,5S,6S)-4-hydroxy-4,6-dimethyl-5-(propionyloxy)tetrahydro-2H-pyran-2-yl)oxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-4-yl propionate

(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-(((2S,3R,4R,5S,6R)-4-(Dimethylamino)-3-hydroxy-5-(((2S,4R,5S,6S)-4-hydroxy-4,6-dimethyl-5-(propionyloxy)tetrahydro-2H-pyran-2-yl)oxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-ox

Midecamycin, 10 mM in DMSO

35457-80-8

3557-80-8

C41H67NO15

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