ChemicalBook > CAS DataBase List > Z-FL-COCHO

Z-FL-COCHO

Product Name
Z-FL-COCHO
CAS No.
1373215-15-6
Chemical Name
Z-FL-COCHO
Synonyms
LY 3000328;Z-FL-COCHO;CATHEPSIN S INHIBITOR;LY 3000328, 10 mM in DMSO;LY3000328，Cathepsin S inhibitor;CATHEPSIN S INHIBITOR ;LY-3000328;LY3000328;Cathepsin,LY3000328,LY 3000328,Inhibitor,LY-3000328,inhibit;(3R,4S)-4-(4-fluorobenzamido)-6-(4-(oxetan-3-yl)piperazin-1-yl)chroman-3-yl methylcarbamate;((3R,4S)-4-((4-FLUOROBENZOYL)AMINO)-6-(4-(OXETAN-3-YL)PIPERAZIN-1-YL)CHROMAN-3-YL)N-METHYLCARBAMATE;N-[(3R,4S)-3,4-Dihydro-3-[[(methylamino)carbonyl]oxy]-6-[4-(3-oxetanyl)-1-piperazinyl]-2H-1-benzopyran-4-yl]-4-fluorobenzamide
CBNumber
CB5175767
Molecular Formula
C25H29FN4O5
Formula Weight
484.52
MOL File
Mol file
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Z-FL-COCHO Property

Boiling point:
701.6±60.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥24.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
Powder
pka
12.50±0.46(Predicted)
color 
White to off-white
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29729
Product name
LY3000328
Packaging
500μg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
29729
Product name
LY3000328
Packaging
10mg
Price
$632
Updated
2024/03/01
Cayman Chemical
Product number
29729
Product name
LY3000328
Packaging
1mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
29729
Product name
LY3000328
Packaging
5mg
Price
$356
Updated
2024/03/01
TRC
Product number
L468955
Product name
LY3000328
Packaging
2.5mg
Price
$525
Updated
2021/12/16
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Z-FL-COCHO Chemical Properties,Usage,Production

Description

LY3000328 is a potent cathepsin S inhibitor (IC50 = 7.7 nM for the human enzyme). It is selective for cathepsin S over cathepsin L, K, B, and V (IC50s = >10,000, >10,000, 4,390, and 21,500 nM, respectively). LY3000328 (1-30 mg/kg) reduces aortic diameter in a mouse model of calcium chloride-induced abdominal aortic aneurysm.

Uses

LY 3000328 is a cathepsin S inhibitor for treatment of abdominal aortic aneurysm. Further provides methods for treating plaque instability, atherosclerosis, or autoimmune disorders such as rheumatoid arthritis, psoriasis, and lupus comprising administering a therapeutically effective amount of a disclosed compound.

target

cathepsin S

References

[1] wiener jj, sun s, thurmond rl. recent advances in the design of cathepsin s inhibitors. curr top med chem. 2010;10(7):717-32.
[2] lee-dutra a, wiener dk, sun s. cathepsin s inhibitors: 2004-2010. expert opin ther pat. 2011;21(3):311-37.

Z-FL-COCHO Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Z-FL-COCHO manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Cathepsin S inhibitor 1373215-15-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Cathepsin S inhibitor 1373215-15-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

1373215-15-6, Z-FL-COCHORelated Search:


  • Z-FL-COCHO
  • ((3R,4S)-4-((4-FLUOROBENZOYL)AMINO)-6-(4-(OXETAN-3-YL)PIPERAZIN-1-YL)CHROMAN-3-YL)N-METHYLCARBAMATE
  • CATHEPSIN S INHIBITOR
  • CATHEPSIN S INHIBITOR ;LY-3000328;LY3000328
  • N-[(3R,4S)-3,4-Dihydro-3-[[(methylamino)carbonyl]oxy]-6-[4-(3-oxetanyl)-1-piperazinyl]-2H-1-benzopyran-4-yl]-4-fluorobenzamide
  • LY 3000328
  • Benzamide, N-[(3R,4S)-3,4-dihydro-3-[[(methylamino)carbonyl]oxy]-6-[4-(3-oxetanyl)-1-piperazinyl]-2H-1-benzopyran-4-yl]-4-fluoro-
  • (3R,4S)-4-(4-fluorobenzamido)-6-(4-(oxetan-3-yl)piperazin-1-yl)chroman-3-yl methylcarbamate
  • LY3000328，Cathepsin S inhibitor
  • Cathepsin,LY3000328,LY 3000328,Inhibitor,LY-3000328,inhibit
  • LY 3000328, 10 mM in DMSO
  • 1373215-15-6
  • C25H29FN4O5