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6-oxopiperidine-3-carboxylic acid

Product Name
6-oxopiperidine-3-carboxylic acid
CAS No.
22540-50-7
Chemical Name
6-oxopiperidine-3-carboxylic acid
Synonyms
6-Oxonipecotic acid;6-ketonipecotic acid;5-Carboxy-2-piperidone;UKRORGSYN-BB BBV-082263;6-Oxopiperidine-3-carboxy...;2-Piperidone-5-carboxylic acid;Piperidin-2-one-5-carboxylic acid;6-oxopiperidine-3-carboxylic acid;6-Oxo-3-piperidinecarboxylic acid;3-PIPERIDINECARBOXYLIC ACID, 6-OXO-
CBNumber
CB51786074
Molecular Formula
C6H9NO3
Formula Weight
143.14
MOL File
22540-50-7.mol
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6-oxopiperidine-3-carboxylic acid Property

Melting point:
181 - 184°C
Boiling point:
437.0±38.0 °C(Predicted)
Density 
1.286
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
pka
4.21±0.20(Predicted)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
O858828
Product name
6-Oxopiperidine-3-carboxylicAcid
Packaging
10mg
Price
$50
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-A5
Product name
6-Oxopiperidine-3-carboxylic acid
Packaging
5G
Price
$450
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-A5
Product name
6-Oxopiperidine-3-carboxylic acid
Packaging
1g
Price
$125
Updated
2021/12/16
Matrix Scientific
Product number
112423
Product name
6-Oxopiperidine-3-carboxylic acid
Packaging
1g
Price
$224
Updated
2021/12/16
Matrix Scientific
Product number
112423
Product name
6-Oxopiperidine-3-carboxylic acid
Packaging
5g
Price
$660
Updated
2021/12/16
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6-oxopiperidine-3-carboxylic acid Chemical Properties,Usage,Production

Uses

6-Oxopiperidine-3-carboxylic Acid can be used to treat progranulin associated disorders.

Synthesis

1356405-59-8

22540-50-7

The optically active compound of 1-(2,4-dimethoxybenzyl)-6-oxopiperidine-3-carboxylic acid (1.36 g) was added to anisole (758 μL) and trifluoroacetic acid (10 mL) as a starting material, and the reaction mixture was stirred for 6 hours at 80 °C. Upon completion of the reaction, the reaction solution was cooled to room temperature and subsequently concentrated under reduced pressure. Diisopropyl ether was added to the concentrated residue and the mixture was stirred at room temperature. The insoluble solid was collected by filtration and dried under reduced pressure to afford the target product 6-oxopiperidine-3-carboxylic acid (628 mg). The structure of the product was confirmed by 1H-NMR (DMSO-D6): δ 1.75-1.88 (m, 1H), 1.91-2.01 (m, 1H), 2.11-2.24 (m, 2H), 2.66-2.73 (m, 1H), 3.21-3.32 (m, 2H), 7.45 (s, 1H), 12.51 (br s, 1H).

References

[1] Patent: US2013/85132, 2013, A1. Location in patent: Paragraph 0754; 0771; 0772; 0773

6-oxopiperidine-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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6-oxopiperidine-3-carboxylic acid Suppliers

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22540-50-7, 6-oxopiperidine-3-carboxylic acidRelated Search:

3-(2-ISOPROPOXYCARBONYL-ETHYL)-6-OXO-PIPERIDINE-3-CARBOXYLIC ACID 2-(3,4-DIMETHOXY-PHENYL)-1-(4-METHOXY-PHENYL)-6-OXO-PIPERIDINE-3-CARBOXYLIC ACID 3-(2-BENZYLCARBAMOYL-ETHYL)-6-OXO-PIPERIDINE-3-CARBOXYLIC ACID 2-(1,3-BENZODIOXOL-4-YL)-1-BUTYL-6-OXO-3-PIPERIDINECARBOXYLIC ACID 1-BUTYL-2-(4-METHOXYPHENYL)-6-OXOPIPERIDINE-3-CARBOXYLIC ACID AURORA KA-4369 1-CYCLOPROPYL-6-OXO-2-PHENYL-3-PIPERIDINECARBOXYLIC ACID 2-(4-CHLOROPHENYL)-2-OXOETHYL 1-BUTYL-6-OXO-2-PHENYL-3-PIPERIDINECARBOXYLATE 1-(4-METHOXYPHENYL)-6-OXO-2-PHENYL-3-PIPERIDINECARBOXYLIC ACID 1-BUTYL-2-(4-NITROPHENYL)-6-OXO-3-PIPERIDINECARBOXYLIC ACID 2-(3-CHLOROPROPYL)-3-(3,4-DIMETHOXYPHENYL)-1-OXO-1,2,3,4,4A,8A-HEXAHYDRO-4-ISOQUINOLINECARBOXYLIC ACID RARECHEM AL BO 1291 1-(4-METHOXYBENZYL)-6-OXO-2-PHENYL-3-PIPERIDINECARBOXYLIC ACID RARECHEM AL BO 1267 1-CYCLOHEXYL-2-(4-ETHOXYPHENYL)-6-OXO-3-PIPERIDINECARBOXYLIC ACID 1-CYCLOHEXYL-6-OXO-2-PHENYL-3-PIPERIDINECARBOXYLIC ACID ETHYL 1-BENZYL-2-OXO-1,3,4,5,6,7-HEXAHYDRO-4A(2H)-QUINOLINECARBOXYLATE 1-BUTYL-6-OXO-2-PHENYL-3-PIPERIDINECARBOXYLIC ACID

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