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5-AMINO-1-(T-BUTYL)PYRAZOLE-4-CARBONITRILE

Product Name
5-AMINO-1-(T-BUTYL)PYRAZOLE-4-CARBONITRILE
CAS No.
158001-28-6
Chemical Name
5-AMINO-1-(T-BUTYL)PYRAZOLE-4-CARBONITRILE
Synonyms
BUTTPARK 51\09-68;5-Amino-1-(tert-butyl);5-amino-4-cyano-1-tert-butyl pyrazole;5-AMINO-1-(T-BUTYL)PYRAZOLE-4-CARBONITRILE;5-AMINO-1-(TERT-BUTYL)PYRAZOLE-4-CARBONITRILE;1H-Pyrazole-4-carbonitrile, 5-amino-1-(1,1-dimethylethyl)-
CBNumber
CB5181454
Molecular Formula
C8H12N4
Formula Weight
164.21
MOL File
158001-28-6.mol
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5-AMINO-1-(T-BUTYL)PYRAZOLE-4-CARBONITRILE Property

Melting point:
92.9-94.5℃
Boiling point:
325.7±27.0 °C(Predicted)
Density 
1.13±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
0.56±0.10(Predicted)
Appearance
Yellow to brown Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A617610
Product name
5-Amino-1-tert-butyl-1h-pyrazole-4-carbonitrile
Packaging
50mg
Price
$95
Updated
2021/12/16
TRC
Product number
A617610
Product name
5-Amino-1-tert-butyl-1h-pyrazole-4-carbonitrile
Packaging
250mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0039033
Product name
5-Amino-1-(tert-butyl)-1H-pyrazole-4-carbonitrile
Packaging
5g
Price
$292
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA36966
Product name
5-Amino-1-(t-butyl)pyrazole-4-carbonitrile
Packaging
250mg
Price
$127.5
Updated
2021/12/16
SynQuest Laboratories
Product number
3H37-1-0J
Product name
5-Amino-1-tert-butyl-1H-pyrazole-4-carbonitrile
Packaging
1g
Price
$200
Updated
2021/12/16
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5-AMINO-1-(T-BUTYL)PYRAZOLE-4-CARBONITRILE Chemical Properties,Usage,Production

Synthesis

7400-27-3

123-06-8

158001-28-6

To an ethanol (600 mL) suspension of tert-butylhydrazine hydrochloride (15.0 g, 120.4 mmol) was added triethylamine (16.8 mL, 120.4 mmol). The mixture was stirred for 60 minutes until the tert-butylhydrazine was completely dissolved. Subsequently, ethoxymethylene malononitrile (14.7 g, 120.4 mmol) was added in batches and the reaction mixture was heated to 80 °C and stirred at this temperature overnight. After completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The obtained residue was dissolved in ethyl acetate (EtOAc), the organic layer was washed with water, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. Finally, the resulting solid was recrystallized in dichloromethane (DCM) to afford 5-amino-4-cyano-1-tert-butylpyrazole (18.6 g, 113.4 mmol, 94% yield) as a light yellow solid.LC-MS (ES+, Method 1): 1.36 min, m/z 165.1 [M + H]+.

References

[1] MedChemComm, 2017, vol. 8, # 3, p. 640 - 646
[2] Patent: WO2017/46604, 2017, A1. Location in patent: Paragraph 00228
[3] Organic Letters, 2012, vol. 14, # 15, p. 3906 - 3908
[4] Patent: CN106008527, 2016, A. Location in patent: Paragraph 0048; 0049; 0050; 0051
[5] European Journal of Organic Chemistry, 2008, # 19, p. 3377 - 3381

5-AMINO-1-(T-BUTYL)PYRAZOLE-4-CARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-AMINO-1-(T-BUTYL)PYRAZOLE-4-CARBONITRILE Suppliers

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158001-28-6, 5-AMINO-1-(T-BUTYL)PYRAZOLE-4-CARBONITRILERelated Search:

5-Amino-3-(benzyloxymethyl)-1-tert-butyl-1H-pyrazole-4-carbonitrile 5-AMINO-1-(TERT-BUTYL)-3-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE 5-AMINO-1-(T-BUTYL)PYRAZOLE-4-CARBONITRILE 5-AMINO-1-(TERT-BUTYL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE 5-Amino-1-tert-butyl-3-(4-methylphenyl)-4-cyanopyrazole 5-AMINO-3-(1-NAPHTHYL)-4-CYANO-1-TERT-BUTYLPYRAZOLE 4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYLMETHYL)-4-CYANOPYRAZOLE 5-amino-1-tert-butyl-3-cyclobutyl-1H-pyrazole-4-carbonitrile 5-amino-1-tert-butyl-3-(2,4-difluorophenyl)-1H-pyrazole-4-carbonitrile 5-amino-1-tert-butyl-3-(3-fluorophenyl)-1H-pyrazole-4-carbonitrile 5-amino-1-tert-butyl-3-[3-(trifluoromethyl)phenyl]-1H-pyrazole-4-carbonitrile 5-amino-1-tert-butyl-3-(2-fluorophenyl)-1H-pyrazole-4-carbonitrile 5-amino-1-tert-butyl-3-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carbonitrile 5-amino-1-tert-butyl-3-furan-2-yl-1H-pyrazole-4-carbonitrile 5-amino-1-tert-butyl-3-(tetrahydrofuran-2-yl)-1H-pyrazole-4-carbonitrile 5-amino-1-tert-butyl-3-cyclopentyl-1H-pyrazole-4-carbonitrile N-[1-(TERT-BUTYL)-3-(4-CHLOROPHENYL)-4-CYANO-1H-PYRAZOL-5-YL]-2-CHLOROBENZENECARBOXAMIDE BUTTPARK 92\50-92

  • 5-AMINO-1-(TERT-BUTYL)PYRAZOLE-4-CARBONITRILE
  • 5-Amino-1-(tert-butyl)
  • 5-AMINO-1-(T-BUTYL)PYRAZOLE-4-CARBONITRILE
  • BUTTPARK 51\09-68
  • 1H-Pyrazole-4-carbonitrile, 5-amino-1-(1,1-dimethylethyl)-
  • 5-amino-4-cyano-1-tert-butyl pyrazole
  • 158001-28-6