4,7-DIBROMO-1H-INDOLE
- Product Name
- 4,7-DIBROMO-1H-INDOLE
- CAS No.
- 126811-31-2
- Chemical Name
- 4,7-DIBROMO-1H-INDOLE
- Synonyms
- 4,7-DIBROMOINDOLE;4,7-DIBROMO-1H-INDOLE;1H-Indole, 4,7-dibroMo-
- CBNumber
- CB5184839
- Molecular Formula
- C8H5Br2N
- Formula Weight
- 274.94
- MOL File
- 126811-31-2.mol
4,7-DIBROMO-1H-INDOLE Property
- Melting point:
- 54-56°
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to brown Solid
Safety
- HazardClass
- IRRITANT
N-Bromosuccinimide Price
- Product number
- D426675
- Product name
- 4,7-Dibromo-1H-indole
- Packaging
- 50mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- HCH0043878
- Product name
- 4,7-DIBROMO-1H-INDOLE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $332.85
- Updated
- 2021/12/16
- Product number
- Z2792
- Product name
- 4,7-Dibromo-1H-indole
- Packaging
- 1g
- Price
- $584
- Updated
- 2021/12/16
- Product number
- 057848
- Product name
- 4,7-Dibromo-1H-indole
- Purity
- 95%
- Packaging
- 1g
- Price
- $732
- Updated
- 2021/12/16
- Product number
- 126811312
- Product name
- 4,7-Dibromoindole
- Packaging
- 500mg
- Price
- $989.8
- Updated
- 2021/12/16
4,7-DIBROMO-1H-INDOLE Chemical Properties,Usage,Production
Uses
4,?7-?Dibromo-?1H-?indole is a reagent used in the synthesis of carbazole carboxamide based inhibitors used in the treatment of lymphomatic leukemia.
Synthesis
3460-18-2
1826-67-1
126811-31-2
General procedure for the synthesis of 4,7-dibromo-1H-indoles from 2,5-dibromonitrobenzene and vinylmagnesium bromide: 1. To a solution of 1,4-dibromo-2-nitrobenzene (18 g, 64.1 mmol) in tetrahydrofuran (THF, 200 mL) was slowly added vinylmagnesium bromide (1.0 M solution in THF, 199 mL, 199 mmol) at -40 °C (dry ice-acetonitrile bath). 2. The reaction mixture was stirred continuously at -40 °C for 1.5 hours. 3. the reaction was quenched with saturated aqueous ammonium chloride (NH4Cl) solution (500 mL) followed by stirring for 1 hour at room temperature. 4. pH was adjusted to 7 by adding 1 M hydrochloric acid (HCl). 5. Ethyl acetate (EtOAc) was added for extraction, the organic phase was separated, washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. 6. The crude product was purified by silica gel column chromatography (330 g silica gel) using ethyl acetate-hexane (5:95) as eluent. 7. The target fraction was collected and concentrated under reduced pressure to give a light yellow oil, which solidified to a solid on standing. 8. 4,7-dibromo-1H-indole (8.35 g, 47% yield) was finally obtained, LCMS analysis showed the main peak, no ionization was observed.
References
[1] Synlett, 1999, # 10, p. 1594 - 1596
[2] Organic Letters, 2010, vol. 12, # 9, p. 2162 - 2165
[3] Patent: WO2011/159857, 2011, A1. Location in patent: Page/Page column 200
[4] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 11, p. 1223 - 1226
[5] Patent: WO2010/145203, 2010, A1. Location in patent: Page/Page column 17
4,7-DIBROMO-1H-INDOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,7-DIBROMO-1H-INDOLE manufacturers
- Product
- 4,7-DIBROMO-1H-INDOLE 126811-31-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200g
- Release date
- 2020-02-01