1,6-Dioxaspiro[2.5]octane

Product Name: 1,6-Dioxaspiro[2.5]octane
CAS No.: 185-72-8
Chemical Name: 1,6-Dioxaspiro[2.5]octane
Synonyms: 1,6-Dioxaspiro[2.5]octane;Tetrahydrospiro[oxirane-2,4'-[4H]pyran]
CBNumber: CB51870452
Molecular Formula: C6H10O2
Formula Weight: 114.14
MOL File: 185-72-8.mol

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1,6-Dioxaspiro[2.5]octane Property

Boiling point:: 60 °C(Press: 145 Torr)
Density: 1.044 g/cm3
storage temp.: 2-8°C

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Safety

RIDADR: 1993
HazardClass: 3
PackingGroup: Ⅲ

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: B415728
Product name: 1,6-Dioxaspiro[2.5]octane
Packaging: 100mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-W008620
Product name: 1,6-Dioxaspiro[2.5]octane
Purity: ≥98.0%
Packaging: 1g
Price: $109
Updated: 2021/12/16

ChemScene

Product number: CS-W008620
Product name: 1,6-Dioxaspiro[2.5]octane
Purity: ≥98.0%
Packaging: 5g
Price: $365
Updated: 2021/12/16

AK Scientific

Product number: Z4331
Product name: 1,6-Dioxaspiro[2.5]octane
Packaging: 10g
Price: $855
Updated: 2021/12/16

ChemScene

Product number: CS-W008620
Product name: 1,6-Dioxaspiro[2.5]octane
Purity: ≥98.0%
Packaging: 25g
Price: $1401
Updated: 2021/12/16

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1,6-Dioxaspiro[2.5]octane Chemical Properties,Usage,Production

Synthesis

29943-42-8

1774-47-6

185-72-8

Trimethylsulfonium oxide iodide (286 mg, 13 mmol) was dissolved in dimethyl sulfoxide (DMSO, 20 mL) under nitrogen protection. Sodium hydride (60% dispersed in mineral oil, 520 mg, 13 mmol) was then added in batches (note: vigorous bubble generation was observed). The resulting suspension was stirred at room temperature for 1 h. Tetrahydro-4H-pyran-4-one (0.93 mL, 10 mmol) was then added slowly and dropwise. The reaction mixture was continued to be stirred for 1 h at room temperature and then the reaction was quenched by pouring into an ice-water mixture. The aqueous phase was extracted with ether (3 x 20 mL), the organic phases were combined, washed sequentially with water and saturated brine and dried over anhydrous magnesium sulfate. After concentration under reduced pressure, 1,6-dioxaspiro[2.5]octane was obtained as a light yellow oil (725 mg, 6.3 mmol, 63% yield).

References

[1] ChemMedChem, 2010, vol. 5, # 1, p. 65 - 78
[2] Patent: WO2017/93543, 2017, A2. Location in patent: Page/Page column 114
[3] Patent: TWI609011, 2017, B. Location in patent: Page/Page column 68; 69
[4] Patent: EP2680844, 2016, B1. Location in patent: Paragraph 0128
[5] Patent: TW2018/8946, 2018, A. Location in patent: Page/Page column 59

1,6-Dioxaspiro[2.5]octane Preparation Products And Raw materials

Raw materials

Preparation Products

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1,6-Dioxaspiro[2.5]octane Suppliers

China 58 India 1 United States 4 Global 63

Shanghai Hanhong Scientific Co.,Ltd.

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SPIRO PHARMA

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Shanghai Kahn Pharmaceutical Co., Ltd.

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View Lastest Price from 1,6-Dioxaspiro[2.5]octane manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 1,6-Dioxaspiro[2.5]octane 185-72-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000KG
Release date: 2024-07-24

Career Henan Chemical Co

Product: 1,6-Dioxaspiro[2.5]octane 185-72-8
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

185-72-8, 1,6-Dioxaspiro[2.5]octaneRelated Search:

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1,6-Dioxaspiro[2.5]octane

Tetrahydrospiro[oxirane-2,4'-[4H]pyran]

185-72-8