1-METHYLADENOSINE

Product Name: 1-METHYLADENOSINE
CAS No.: 15763-06-1
Chemical Name: 1-METHYLADENOSINE
Synonyms: N1-Me-rA;N1-Me-Adenosine;1-METHYLADENOSINE;Adenosine, 1-methyl-;1-methyladenosine free base;1-Methyladenosine, 10 mM in DMSO;N,6-Didehydro-1,6-dihydro-1-methyladenosine;(2R,3R,4R,5R)-2-(hydroxymethyl)-5-(6-imino-1-methyl-purin-9-yl)oxolane-3,4-diol;inhibit,1-Methyladenosine,1 Methyladenosine,Endogenous Metabolite,Inhibitor,1Methyladenosine;(2R,3R,4S,5R)-2-(6-Amino-1-methyl-1H-purin-9(2H)-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
CBNumber: CB5187128
Molecular Formula: C11H15N5O4
Formula Weight: 281.27
MOL File: 15763-06-1.mol

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1-METHYLADENOSINE Property

Melting point:: >217°C (dec.)
Boiling point:: 655.4±65.0 °C(Predicted)
Density: 1.88±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMSO (Slightly), Water (Slightly, Sonicated)
form: Solid
pka: 13.24±0.70(Predicted)
color: White to Off-White
PH: 8.8
λmax: 258 (pH 2)；258 (pH 7)；259，260～265 (pH 13)
Stability:: Hygroscopic, Light Sensitive
InChI: InChI=1/C11H15N5O4/c1-15-3-14-10-6(9(15)12)13-4-16(10)11-8(19)7(18)5(2-17)20-11/h3-5,7-8,11-12,17-19H,2H2,1H3/t5-,7-,8-,11-/s3
InChIKey: GFYLSDSUCHVORB-ABFAXUGDNA-N
SMILES: N1(C=NC2C(=N)N(C)C=NC1=2)[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 |&1:11,12,14,16,r|

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Safety

Safety Statements: 24/25
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16937
Product name: 1-methyl Adenosine
Purity: ≥98%
Packaging: 25mg
Price: $47
Updated: 2024/03/01

Cayman Chemical

Product number: 16937
Product name: 1-methyl Adenosine
Purity: ≥98%
Packaging: 50mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 16937
Product name: 1-methyl Adenosine
Purity: ≥98%
Packaging: 100mg
Price: $96
Updated: 2024/03/01

Cayman Chemical

Product number: 16937
Product name: 1-methyl Adenosine
Purity: ≥98%
Packaging: 250mg
Price: $182
Updated: 2024/03/01

TRC

Product number: M285065
Product name: 1-MethylAdenosine
Packaging: 100mg
Price: $95
Updated: 2021/12/16

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1-METHYLADENOSINE Chemical Properties,Usage,Production

Description

1-Methyladenosine is a modified nucleoside generated by the processing of tRNA by methyltransferases. The urinary excretion of 1-methyladenosine is elevated in several forms of cancer, supporting its use as a biomarker in early detection. It can also be monitored in serum. Urinary levels of 1-methyladenosine also increase during active rheumatoid arthritis.

Chemical Properties

White to off-white crystalline powder

Uses

1-Methyl Adenosine is a modified adenosine molecule created through the processing of tRNA by methyltransferases. The presence seen to be elevated in the urinary excretion of cancer patients. Thus it may be an early diagnosis biomarker.

Definition

ChEBI: A methyladenosine carrying a methyl substituent at position 1.

References

[1] T. MUNNS H S. Methylation and processing of transfer ribonucleic acid in mammalian and bacterial cells.[J]. The Journal of Biological Chemistry, 1975, 4 1: 2143-2149. DOI: 10.1016/s0021-9258(19)41693-1
[2] VOLD B. Modified nucleosides of Bacillus subtilis transfer ribonucleic acids.[J]. Journal of Bacteriology, 1976, 127 1: 258-267. DOI: 10.1128/jb.127.1.258-267.1976
[3] TAKESHI CHUJO Tsutomu S. Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs.[J]. RNA, 2012, 18 12: 2269-2276. DOI: 10.1261/rna.035600.112
[4] C. REYNAUD . Monitoring of urinary excretion of modified nucleosides in cancer patients using a set of six monoclonal antibodies[J]. Cancer letters, 1992, 61 3: Pages 255-262. DOI: 10.1016/0304-3835(92)90296-8
[5] A SEIDEL. Modified nucleosides: an accurate tumour marker for clinical diagnosis of cancer, early detection and therapy control[J]. British Journal of Cancer, 2006, 94 11: 1726-1733. DOI: 10.1038/sj.bjc.6603164
[6] WEI-YI HSU. Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese.[J]. PLoS ONE, 2013: e81701. DOI: 10.1371/journal.pone.0081701
[7] FENG CHEN. Identification of serum biomarkers of hepatocarcinoma through liquid chromatography/mass spectrometry-based metabonomic method[J]. Analytical and Bioanalytical Chemistry, 2011, 401 6. DOI: 10.1007/s00216-011-5245-3
[8] J G TEBIB. Relationship between urinary excretion of modified nucleosides and rheumatoid arthritis process.[J]. British journal of rheumatology, 1997, 36 9: 990-995. DOI: 10.1093/rheumatology/36.9.990

1-METHYLADENOSINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-METHYLADENOSINE Suppliers

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View Lastest Price from 1-METHYLADENOSINE manufacturers

Career Henan Chemical Co

Product: 1-METHYLADENOSINE 15763-06-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons
Release date: 2020-03-04

15763-06-1, 1-METHYLADENOSINERelated Search:

2''-Deoxy-N6-methyladenosine 1-methylpseudouridine 1-MethylInosine N1-Ethylpseudouridine 1-METHYLGUANOSINE (1-Methyl-1H-imidazol-4-yl)methylamine 2'-C-Methyladenosine N6-BENZOYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLADENOSINE 2'-O-METHYLADENOSINE N6-METHYLADENOSINE 2-AMINO-N2-ISOBUTYRYL-2'-O-METHYLADENOSINE 2-(1-Hexynyl)-N6-methyladenosine,2-(1-HEXYNYL)-N-METHYLADENOSINE 2-AMINO-5'-O-(DIMETHOXYTRITYL)-N6-(DIMETHYLAMINOMETHYLIDENE)-N2-(ISOBUTYRYL)-2'-O-METHYLADENOSINE N1-METHYLADENOSINE HYDROIODIDE 1-METHYLADENOSINE 2-AMINO-2'-O-METHYLADENOSINE 2-methyladenosine 8-(4-Chlorophenylthio)-2μ-O-methyladenosine 3μ,5μ-cyclic monophosphate hydrate monosodium

N,6-Didehydro-1,6-dihydro-1-methyladenosine

1-METHYLADENOSINE

1-methyladenosine free base

(2R,3R,4R,5R)-2-(hydroxymethyl)-5-(6-imino-1-methyl-purin-9-yl)oxolane-3,4-diol

(2R,3R,4S,5R)-2-(6-Amino-1-methyl-1H-purin-9(2H)-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

Adenosine, 1-methyl-

N1-Me-Adenosine

N1-Me-rA

inhibit,1-Methyladenosine,1 Methyladenosine,Endogenous Metabolite,Inhibitor,1Methyladenosine

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-imino-1-methyl-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3,4-diol

1-Methyladenosine, 10 mM in DMSO

15763-06-1

Nucleosides, Nucleotides, Oligonucleotides

Nucleoside Analogs

Biochemicals and Reagents

BioChemical

Biochemicals and Reagents

Nucleoside Analogs

Nucleosides, Nucleotides, Oligonucleotides