4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine
- Product Name
- 4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine
- CAS No.
- 40656-71-1
- Chemical Name
- 4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine
- Synonyms
- NSC 158900;2-chloro-3-Deazaadenosine;6-Amino-2-chloro-9-(b-D-ribofuranosyl)purine;4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine;4-Amino-6-chloro-1-β-D-ribofuranosylimidazo[4,5-c]pyridine;6-Chloro-1-β-D-ribofuranosyl-1H-iMidazo[4,5-c]pyridin-4-aMine;1H-Imidazo[4,5-c]pyridin-4-amine, 6-chloro-1-β-D-ribofuranosyl-;(2R,4R,5R)-2-(4-amino-6-chloroimidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol;(2R,3R,4S,5R)-2-(4-amino-6-chloro-1H-imidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
- CBNumber
- CB51872799
- Molecular Formula
- C11H13ClN4O4
- Formula Weight
- 300.7
- MOL File
- 40656-71-1.mol
4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine Property
- Melting point:
- 223-225°C
- Boiling point:
- 694.6±65.0 °C(Predicted)
- Density
- 2.02±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- DMSO, Methanol
- form
- Solid
- pka
- 13.18±0.70(Predicted)
- color
- Off-White to Beige
N-Bromosuccinimide Price
- Product number
- 9000787
- Product name
- 2-chloro-3-Deazaadenosine
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $77
- Updated
- 2024/03/01
- Product number
- 9000787
- Product name
- 2-chloro-3-Deazaadenosine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $340
- Updated
- 2024/03/01
- Product number
- 9000787
- Product name
- 2-chloro-3-Deazaadenosine
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $602
- Updated
- 2024/03/01
- Product number
- A603514
- Product name
- 4-Amino-6-chloro-1-β-D-ribofuranosylimidazo[4,5-c]pyridine
- Packaging
- 1mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- NC09808
- Product name
- 2-Chloro-3-deazaadenosine
- Packaging
- 1mg
- Price
- $75
- Updated
- 2021/12/16
4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
Adenosine analog
Biological Activity
2-chloro-3-deazaadenosine, a stable analog of adenosine, is an agonist for adenosine receptors [1].adenosine receptors are members of g-protein-coupled receptors (gpcrs). extracellular adenosine acts as a local modulator with a generally cytoprotective function in the body. extracellular adenosine has been implicated in increasing the ratio of oxygen supply to demand, protecting against ischaemic damage by cell conditioning, triggering anti-inflammatory responses and the promotion of angiogenesis [2].
in vitro
the ki values of 2-chloro-3-deazaadenosine for a1, a2a, a2b, and a3 receptors were 0.3, 0.08, 25.5, and 1.9 μm, respectively [1]. 2-chloroadenosine (25 μm) increased activity of platelet adenylate cyclase to about 150–160% of the control value. higher concentrations of 2-chloroadenosine showed less effect above 100 μm [3].
in vivo
in the rat with delayed ischaemic damage, iterative focal injections of 2-chloroadenosine protected against selective hippocampal ca1 loss [4].
References
[1] linden j, thai t, figler h, et al. characterization of human a2b adenosine receptors: radioligand binding, western blotting, and coupling to gqin human embryonic kidney 293 cells and hmc-1 mast cells[j]. molecular pharmacology, 1999, 56(4): 705-713.
[2] jacobson k a, gao z g. adenosine receptors as therapeutic targets[j]. nature reviews drug discovery, 2006, 5(3): 247-264.
[3] haslam r j, lynham j a. activation and inhibition of blood platelet adenylate cyclase by adenosine or by 2-chloroadenosine[j]. life sciences, 1972, 11(23): 1143-1154.
[4] evans m c, swan j h, meldrum b s. an adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus[j]. neuroscience letters, 1987, 83(3): 287-292.
4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine manufacturers
- Product
- (2R,4R,5R)-2-(4-amino-6-chloroimidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol 40656-71-1
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g;1kg； 25kg
- Release date
- 2020-01-09