3',4',5'-TRIFLUOROACETOPHENONE

Product Name: 3',4',5'-TRIFLUOROACETOPHENONE
CAS No.: 220141-73-1
Chemical Name: 3',4',5'-TRIFLUOROACETOPHENONE
Synonyms: 3',4',5'-TRIFLUOROACETOPHE;3,4,5-TRIFLUOROACETOPHENONE;3',4',5'-Trifluoroacetophenone;1-(3,4,5-trifluorophenyl)ethanone;3',4',5'-Trifluoroacetophenone97%;3',4',5'-Trifluoroacetophenone 97%;Ethanone, 1-(3,4,5-trifluorophenyl)-;1-(3,4,5-Trifluorophenyl)ethan-1-one;3′,4′,5′-Trifluoroacetophenone, CAS 220141-73-1
CBNumber: CB5193754
Molecular Formula: C8H5F3O
Formula Weight: 174.12
MOL File: 220141-73-1.mol

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3',4',5'-TRIFLUOROACETOPHENONE Property

Boiling point:: 209℃
Density: 1.303
refractive index: 1.473
Flash point:: >100°C
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
color: Colorless to Light yellow
CAS DataBase Reference: 220141-73-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,F
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: 1993
Hazard Note: Irritant/Flammable
HazardClass: IRRITANT
HS Code: 2914790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T3825
Product name: 3',4',5'-Trifluoroacetophenone
Packaging: 5G
Price: $63
Updated: 2025/07/31

TCI Chemical

Product number: T3825
Product name: 3',4',5'-Trifluoroacetophenone
Packaging: 25G
Price: $190
Updated: 2025/07/31

American Custom Chemicals Corporation

Product number: HCH0020656
Product name: 3',4',5'-TRIFLUOROACETOPHENONE
Purity: 95.00%
Packaging: 1G
Price: $613.31
Updated: 2021/12/16

Apolloscientific

Product number: PC6755
Product name: 3',4',5'-Trifluoroacetophenone
Purity: 98%
Packaging: 100g
Price: $218
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0020656
Product name: 3',4',5'-TRIFLUOROACETOPHENONE
Purity: 95.00%
Packaging: 5G
Price: $892.82
Updated: 2021/12/16

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3',4',5'-TRIFLUOROACETOPHENONE Chemical Properties,Usage,Production

Chemical Properties

colorless to clear liquid

Uses

3',4',5'-Trifluoroacetophenone is an organic intermediate that can be used to prepare the key mother nucleus (S)-N-[4-(1-aminoethyl)-2,6-difluorophenyl]methanesulfonamide of vanilloid compounds.

Synthesis

108-24-7

138526-69-9

220141-73-1

The general procedure for the synthesis of 3,4,5-trifluoroacetophenone from ethanoic anhydride and 3,4,5-trifluorobromobenzene was carried out as follows: firstly, iodine (361 mg, 1.42 mmol) was added to a solution of magnesium (3.53 g, 145 mmol) in tetrahydrofuran (100 ml) at room temperature, followed by slow dropwise addition of 3,4,5-trifluorobromobenzene (30.0 g, 142 mmol). The reaction mixture was stirred at the same temperature for 30 minutes. Next, a toluene solution (100 ml) containing copper (I) chloride (704 mg, 7.11 mmol) and acetic anhydride (16.0 g, 156 mmol) was added to the reaction mixture at 0°C. The reaction mixture was continued to be stirred at 0°C for 1 hour. After completion of the reaction, the mixture was poured into 2N aqueous hydrochloric acid solution and extracted with toluene. The extract was washed with saturated brine, dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure. The concentrated product was purified by silica gel column chromatography using ethyl acetate/hexane (1/10) as elution solvent to give 3,4,5-trifluoroacetophenone as a final yellow oil (yield 21.0 g, 85% yield).

References

[1] Patent: JP2016/84346, 2016, A. Location in patent: Paragraph 0056
[2] Patent: JP2016/84328, 2016, A. Location in patent: Paragraph 0191

3',4',5'-TRIFLUOROACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3',4',5'-TRIFLUOROACETOPHENONE Suppliers

China 133 France 1 Germany 2 India 4 Italy 1 Japan 1 United Kingdom 11 United States 14 Global 167

J & K SCIENTIFIC LTD.

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Energy Chemical

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View Lastest Price from 3',4',5'-TRIFLUOROACETOPHENONE manufacturers

Speranza Chemical Co., Ltd.

Product: 3',4',5'-Trifluoroacetophenone 220141-73-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100MT/Year
Release date: 2024-11-06

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3",4",5"-TRIFLUOROACETOPHENONE 220141-73-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3",4",5"-TRIFLUOROACETOPHENONE 220141-73-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

220141-73-1, 3',4',5'-TRIFLUOROACETOPHENONERelated Search:

2',4',5'-Trifluoroacetophenone Ethyl 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate PENTAFLUOROPHENACYL BROMIDE 2',3',4',5'-TETRAFLUOROACETOPHENONE DECAFLUOROBENZOPHENONE 2,3,4,5,6-PENTAFLUOROBENZOPHENONE 2',3',4',5',6'-PENTAFLUOROACETOPHENONE Ethyl 2,3,4,5-tetrafluorobenzoyl acetate 3',4',5'-TRIFLUOROACETOPHENONE Ethyl (pentafluorobenzoyl)acetate 3,4,5-TRIFLUOROBENZOPHENONE 4-Carboxy-alpha,alpha,alpha-trifluoroacetophenone 4-FLUORO-A,A,A-TRIFLUOROACETOPHENONE,4-FLUORO-ALPHA,ALPHA,ALPHA-TRIFLUOROACETOPHENONE 4'-(DIMETHYLAMINO)-2,2,2-TRIFLUOROACETOPHENONE,4'-N,N-DIMETHYLAMINO-2,2,2-TRIFLUOROACETOPHENONE Trifluoroacetophenone 4'-Ethoxyl-2,2,2-trifluoroacetophenone 2,2,2-TRIFLUORO-3'-(TRIFLUOROMETHYL)ACETOPHENONE 2'',3'',4''-TRIFLUOROACETOPHENONE

3,4,5-TRIFLUOROACETOPHENONE

3',4',5'-Trifluoroacetophenone 97%

3',4',5'-Trifluoroacetophenone97%

1-(3,4,5-trifluorophenyl)ethanone

1-(3,4,5-Trifluorophenyl)ethan-1-one

Ethanone, 1-(3,4,5-trifluorophenyl)-

3',4',5'-Trifluoroacetophenone

3',4',5'-TRIFLUOROACETOPHE

3′,4′,5′-Trifluoroacetophenone, CAS 220141-73-1

220141-73-1

Fluorine series

ketone